TL

ChromosOmics - Database

Icon by Leon Liehr

- Disclaimer for sSMC -

Here all for the author of this internet presence available data for sSMC is collected per chromosomal origin of the sSMC.
At the beginning of single chromosome-specific subpages there are schematic drawings describing the presently known dosage(in)sensitive centromer-near regions.

For these the following DISCLAIMER is to be considered:

Here, the data for the chromosome shown on this sub-page is summarized schematically!
It is based on the hypothesis that a genetic imbalance induced by sSMC presence is the major reason for clinical symptoms in sSMC carriers. Here regions of partial tri- or polysomy cause by an sSMC and the potential clinical outcome is assembled - only no clinical problems (green) are compared to more or less severe clinical problems (red). Other factors like mosaicism, UPD or point mutations in any potentially disease causing genes are not included here.
Disclaimer: the following scheme represents the interpretation of the presently available data on sSMC. It can be used for interpretation of cytogenetic findings - however, there are always exceptions from the findings to be expected. Some are even already described on this page. Thus, please use this simplifying scheme carefully!!! We do not take any responsibility for (mis)interpretation of this scheme.