TL

ChromosOmics - Database

Tumor cell lines characerized by M-FISH/ MCB / aCGH

COUNTER

How to cite this database:-
Liehr T. 2024. Detailed karyotypes of tumor cell lines.
https://cs-tl.de/DB/TC/CLs/0-Start.html [accessed on ...]

Visitors

in 2023: 100

last update: 01. Jan. 2024

[VG-Wort ()]

Created by Dr. Thomas Liehr (PhD)
professional affiliation: Institute of Human Genetics, 07740 Jena, Germany;
e-mail: Thomas.Liehr@med.uni-jena.de or: LiehrT@web.de

Cell lines overview

Cell lines included here were characterized in the molecular cytogenetic lab Jena, Germany.

Human cell lines - click here
Chordoma	U-CH1
Colon cancer	AGP01	HCT116 p53 +/+	HCT116 p53 −/−	HT-29 Cl. 19A	LT97	SW480
Endothelial	hCMEC/D3
Head and neck cancer	BICR10	HSC-3
Leukemia	CCRF CEM	CCRF CEM1	CCRF CEM2	CEM/ADR5000	CEM/MTX60	CEM/MTX140
	CEM/MTX1500	CEM/MTXR1	CEM/MTXR2	CEM/MTXR3	CEM/VCR1000	KCL22-R
	KCL22-S
Lymphoma	GRANTA-519
Trophoblast	AC-1M59	ACH-3P	BeWo	HTR8/SVneo	JAR	JEG-3

Murine cell lines - click here
Breast cancer	C-127I	EMT6/P	JC	MMT 060562	TA3 Hauschka
Burkitt's lymphoma	A-20
Colorectal cancer	CMT-93	CT26
Ectodermal tumor	NIH 3T3
Lung cancer	KLN 205	LA-4
Liver cancer	Hepa 1-6	MH-22A
Malignant melanoma	B16-F0	B16-F1	B16-F10	B16-4A5	C57/B1	S91 clone M3
Malignant mesothelioma	AB1	AB22	AC29	AE17
Salvary gland tumor	WR21	SCA-9
Testis tumor	I-10	MLTC-1

Murine cell lines

name	karyotype	methods	model for human cancer	Reference
breast cancer (BC)
C-127I	clone 1 [20%]: 94~96<5n>,XXX,-2,der(4)t(4;10)(C4;C1),der(4)t(4;10)(C4;C1),+der(4)t(4;5)(C4;F),der(6)(pter→A1::G3→E::B3→D:),del(6)(D),+del(6)(A2),-7,+8,-9,dic(11;18)(A1;A1),inv(12)(BE),-12,-12,del(13)(B1),del(14)(D3),-14,+15,-16,+17,-18,-18,+19 clone 2 [40%]: as clone 1 but -8,-17,+der(17)t(11;17)(A3;B3) clone 3 [23%]: as clone 1 but -12,-12,+del(12)(A1.1) clone 4 [17%]: as clone 1 but +der(5)t(5;13),-10,-18,idic(18)	mFISH (wcps) mcb aCGH	advanced stage BC	{6}
EMT6/P	clone 1 [40%]: 59~64[3n],X,der(X)t(X;5)Xpter->XA1::XA6->XF5::5C3->5qter),der(3)(pter->H1::H1->F2:),+der(3)(pter->H1::H1->F2:),der(4)pter->C5::E2->C5::C5->D2:),der(5)(5A1->5C3::5B1->5C3::15D1->15qter),+6,idic(8)(A1;A1),+8,idic(10)(A1;A1),idic(12)(A1;A1),dup(13)(C3A2),idic(14)(A1;A1),dup(15)(CA2),+17,+19. clone 2 [20%]: as clone 1 but der(5) replced by der(5)t(5;15)(B1;D1); clone 3 [10%]: as clone 1 -12,-12,+idic(12)(A1A1); clone 4 [7%] as clone 1 -3,+der(3)t(2;3)(3pter->3H1::2?->2?qter),+der(2)t(2;3)(2?pter->2?::3H1->3F2:); clone 5 [23%]: t(2;11)(C3;D),t(9;18),+der(9)t(9;18)(9pter->9?::18A2->18qter),+der(18)t(9;18)(18pter->18E2::9?->9qter)	mFISH (wcps) mcb aCGH	premalignant or early malignant stage BC	{6}
JC	clone 1 [17%]: 64-66<4n>,XXX,-X,del(1)(E2),dic(2;9)(A1;A1),-3,- 4,del(5)(B),der(6)(:14B→14A1::6A1→6B3::6B3→6B 1::6B1→6B3::6B3→6B1::6B1→6B3::16C1→16qter),- 7,idic(8)(A1;A1),dic(9;13)(:13A5->13A5:::9A1→9q ter),-10,-12,+13,-14,-16,-17,-18,-19 clone 2 [53%]: 64-66<4n>,idem,XX,-X,- X,idem,t(3;14)(H4;D1),+6,+15,dup(17)(A2D1) clone 3 [~30%]: 64-66<4n>idem,XX,der(X)(X;?)(pter→A6::?), -X,t(3;14)(H4;D1),+6,der(?)(?;11)(pter→A1::E1→qter),del(13)(A5),dup(17)(A2D1),+15	mFISH (wcps) mcb aCGH	luminal B, basal-like BC	{10}
MMT 060562	clone 1 [42%]: 46,XY clone 2a [11.3%]: 41,XY,inv(2)(C3E5),+6 clone 2b1 [28.5%]: 41,XY,+6,der(14)t(13;14)(14pter→14D1::14B→14D1::13A3→3qter) clone 2b2 [18.2%]: 40,XY,dic(2;17)(A1A1),del(3)(A3C),+6,der(14)t(13;14)(14pter→14D1::14B→14D1::13A3→13qter)	mFISH (wcps) mcb aCGH	early stage basal-like tumor type BC	{11}
TA3 Hauschka	clone 1 [50%]: 41,X,der(X)(XA1->XA5::19C2->19D2::19D1->19qter),t(1;7)(B;F2),t(1;14)(G;E1),inv(3)(E1H4),del(4)(C3D2),t(6;16)(F3;C3),+6,t(12;13)(E;C1),+16,der(19)t(X;19)(C2;A6),del(19)(D2); clone 2 [30%]: +t(3;11)(G;E1), instead of der(19) from clone 1 der(19)(19pter->19C2::XA6->XF5::8D1->8qter) clone 3 [20%]: instead of del(4) a der(4)t(4;6;16)(A2;F3;C3)	mFISH (wcps) mcb aCGH	early stage BC	{6}
Burkitt's lymphoma
A-20	clone 1 [95%]:39,X,-X or -Y,t(2;15)(qE5;qD2),del(6)(qB3qC3),del(9)(qA3qA4),dup(14)(qE1qE4) (95% of cells) 5% of cells show chromothripsis	mFISH (wcps) mcb aCGH	Burkitt's lymphoma	{3}
colorectal cancer (CRC)
CMT-93	clone 1 [50%]: 48~56,XXY,+der(2)(neo::G2→qter),+3,+der(4)(neo::C6→C7:),+5,+6,+der(8)(pter→D1::D1→C2:),+der(8)(neo::B1.1→qter),+der(8)(neo::C2→qter)x2,+11,+12,+13,dic(14;15)(A1;A1),+15,+17,+18,+19,+19 clone 2 [50%]: 49~54,XXY,+der(2)(neo:G2→qter),+3,+der(4)(neo::C6→C7:),+5,+6,+der(8)(pter→D1::D1→C2:),+der(8)t(2;8)(B1.1;E1),+der(8)(neo:C2→qter),+11,+13,dic(14;15)(A1;A1),+15,+17,+19.	mFISH (wcps) mcb aCGH	advanced type of metastatic CRC	{4}
CT26	clone 1 [29%]: 59~61,XX,dic(1;14)(A1;A1),+1,+der(2)t(2;9)(neo::2H2→2C3::9E2→9qter),der(3)t(3;15)(3pter→3H4::neo::3F3→3qH4::3H4→3E1::15A1→15qter),dic(5;15)(A1;A1),dic(5;19)(A1;A1),+dic(5),dic(6;6)(A1;A1),+der(6)(3qter→3A1::6A3→6A1:6A1→6G3::10C3→10qter),+der(7)t(7;19)(D1;D1),+8,der(9)t(2;9)(H2;E1),dic(12;12)(A1;A1),dic(13;13)(A1;A1),dic(13;17)(A1;A1),+der(13)(neo:A3→C3:),dic(14;14)(A1;A1),+17,+19,+mar1x2 clone 2 [26%]: 66~68,idem,+der(18)(pter→C::B3→qter), +19,+mar2x2,+mar3x3 clone 3 [20%]: 60~62,idem,+dic(X;12)(A5;A1) clone 4 [~25%]: as clone 1 in tetraploid condition	mFISH (wcps) mcb aCGH	advanced type of metastatic CRC	{4, 0}
ectodermal tumor
NIH 3T3	75,X,der(X)(XA1->XF5::XE->Xqter),der(Y)t(Y;7) (C3;E3),-Y,der(3)t(3;15)(3A1->3E2::3E2->3A1::15F2- >15qter),-4,del(4)(C3),der(4)(A1->C7::C3->qter),del(5) (BC),del(7)(E3),der(7)t(Y;7)(C3;E3),-9,+10,-13,der(13) t(13;3)(13A1->13D2::13C3->13D2::3E2->3qter),- 14,del(14)(D2),-15,der(15;15)(A1;A1),der(16)t(4;16) (16A1->16B2~B3::4C3->4C7::4C3->4qter),-18,+del(?) (A1)	mFISH (wcps) mcb	solid tumor from ectodermal origin	{1}
lung cancer
KLN 205	clone 1 [43.3%]: 77-82<4n>,XXYYYY,-2,del(3)(A3D),der(3)(A1→A3::D→G3:),-4,+del(5)(C3),-7,-8,der(9)t(9;10)(A5;A1),-13,der(14)t(2;14)(A2;A1),+15,-17,del(19)(D) clone 2 [20%]: as clone 1, but +del(5)(C3) instead of +5 and four chromosomes 12 instead of three clone 3 [13.4%], same as clone 2 but four chromosomes 2 clone 4 [13.4%], same as clone 2 but four chromosomes 2, and no der(9)t(9;10)(A5;A1)	mFISH (wcps) mcb aCGH	squamous cell carcinoma (SCC) or even lung cancer in general	{13}
LA-4	clone 1 [88%]: 85~93<4n>,X,dic(X;5)(Xqter→XA1::5G2→5qter), ‑X,‑X,‑4,‑4,der(4)t(3;4)(G;E2),der(5)t(4;5)(A4;C3),del(5)(G2),inv(6)(A1C),+neo(7)(:F3‑>qter),+dic(7;11)(7A1→7F3::11A2→11qter),+8,+8, del(10)(B5),+idic(10)(A1;A1)x3,neo(11)(:B3‑>qter),‑13,‑14,+15, +der(15)t(13;15)(C2;D3),+17,+17,der(18)t(6;18)(B1;E3)x2,+19, +19,+19. 'clone 2' [12%]: identical structural aberrations, but random loss of single chromosomes was observed; chromosome numbers ranged from 67 to 72. Preferentially lost chromosomes were 1, 2, 6, 9, 15, 18 and 19.	mFISH (wcps) mcb aCGH	non‑metastatic human lung squamous cell carcinoma	{14}
liver cancer
Hepa 1-6	68~71<3n>,X,del(X)(A3A7),+der(X)t(X;2)(A3;A3),+der(X)t(X;13) (A3;A1),+der(X)t(X;13)(A3;A1),+der(X)t(X;13)(A3;A1),+der(X)t(X;13) (A3;C1),dic(1;8)(A1;A1),+dic(1;8)(A1;A1),-2,-2,der(4)t(4;16)(4A1→4C3::4C7→4E2::16B5→16Cqter),del(4)(D2E2)x1~2,der(5)t(2;5)(A2;G2),+del(6)(A2F1),+6,-8,+10,+11,-13,-13,-13,der(14)t(2;14)(H2;D2),del(14)(A3E4)x1~2,dic(15)(15qter→15F1:cen:15A1→15F3::15F3→15A1::2G1→2qter),+idic(15)(7qter→7F2::15F1→15A1::15A1→15A1::7F2→7qter),+18,+del(18)(D1),der(19)t(5;19;5)(F;D2),+der(19)t(5;19;5)(F;D2),+der(19)t(5;19) (F;D2)	mFISH (wcps) mcb aCGH	advanced hepatocellular carcinoma (HCC)	{9}
MH-22A	56~57<3n>,XX,-X or Y,der(2)(A1→B::B→A3::C3→H1::H1→H4),der(5) (A1→G3::G3→F::F1→12qter),+3,dic(5)(A1→C1::C1→A1:CEN:A1→B 1~3:),der(5)t(5;12)(F1;F1),+dic(5;15)(12F2→12F1::5F→5G3::CEN::CEN ::15A1→15qter),+dic(6;17)(A1;A1),der(12)(A1→B1::A1.2→B1:),del(13) (D1D2.3),der(14)(4A1→14D1::14C1→14D1::7D3→7E3::7?E3~F1::?7E1: :14C2→14C3::18B3→18E4),-14,-16,der(16)(A1→C3::B1→C4),-18	mFISH (wcps) mcb aCGH	Hepatoblastoma or early stage HCC	{9}
malignant melanoma (MMa)
B16-F0	clone 1 [75%]: 71~77,X,der(X)t(X;15)(D;B3), der(1)t(1;16)(F;A1),+del(1)(BE),der(3)t(3;13)(F3A3),der(3)t(3;13)(F3A3),inv(4)(A1C1),del(5)(DF),inv(6)(B2G1),+6,+6,+6,idic(7)(A1;A1),der(8)t(8;9)(A4;F3),+der(8)t(8;12)(C2;C1),+del(11)(A2B1),idic(12)(A1;A1),der(13)t(3;13)(F3;A3),-14,del(15)(A1A3),-15,-16,dic(17;19)t(17;19)(19qter→19A::CEN::17A3→17B1::17C→17D::19B→19qter) clone 2: as clone 1 but der(4)(pter→D2::A1→C5:) replaced one normal chromosome 4	mFISH (wcps) mcb aCGH	metastatic skin MMa	{8}
B16-F1 line from ATCC	70–77<4n>,X,–X∼Y,–X∼Y,der(X)t(X;15)(D;B3),der(1)t(1;12)(1pter→1C3:1E2→1F:12F1→12qter),+der(1)t(1;16)(1E2∼4→1A3:16A1→16qter),der(3)t(3;13)(F3A3),der(3)t(3;13)(F3A3),–4,del(5)(DF),+6,+6,der(8)t(1;8)(E2;C1),dic(8;12)(:8D→8A1:12A1→12qter),–10,+der(11),–12,idic(12)(A1;A1),idic(12;15)(A1;A1),der(13)t(3;13)(F3;A3),–13,–14,–15,–16,+dic(17;19)t(17;19)(19qter→19A:CEN:17A3→17B1:17C→17D:19B →19qter),–18,–19	mFISH (wcps) mcb aCGH	aggressive or advanced/maybe metastatic MMa from skin and eye	{12}
B16-F1 line from lab in Mainz, Germany	70–75<4n>,X,-X~Y,-X~Y,der(X)t(X;15),der(1)t(1;12),+der(1)t(1;16), der(3)t(3;13),der(3;13),-4,del(5),+6,der(8)t(1;8),dic(8;12),-10, +11,+der(11),-12,idic(12),idic(12;15),der(13)t(3;13),-13,-15,-16, dic(17;19),-19	mFISH (wcps)	aggressive or advanced/maybe metastatic MMa from skin and eye	{31}
B16-F10	70–75<4n>,X,-X~Y,-X~Y,der(X)t(X;15),der(1)t(1;12),+der(1)t(1;16), der(3)t(3;13),der(3;13),-4,dic(4)(pter→E2::E2→pter),del(5), +dic(6;15),der(8)t(1;8),+der(10)t(10;?1;16),+der(11),-12,idic(12), der(13)t(3;13),der(13)t(3;13),-13,-14,-16,-16,dic(17;19),-18,-19	mFISH (wcps)	aggressive or advanced/maybe metastatic MMa from skin and eye	{31}
B16-4A5	69–75<4n>,XX,–X∼Y,–X∼Y,–3,der(3)t(3;13)(F3;A3.1),–4,dic(5;15)(A1;A1),dic(5;15)(A1;A1),+dup(inv)(6)(pter→B3::B3→B1::G1∼3→F2:hsr),+der(6)t(3;13;6)(6pter→6C1::3E1→3F3::13A3.1→13qter),–8,idic(8)(A1;A1),del(12)(C1E),del(12)(C1E),idic(12)(A1;A1),idic(12)(A1;A1),–13,+der(13)(:D?2→D?2),der(13)t(3;13)(F3;A3.1),–15,–15,+del(18)(A1B1)	mFISH (wcps) mcb aCGH	aggressive or advanced/maybe metastatic MMa from skin and eye	{12}
C57/B1	clone 1 [20%]: 40,X,t(3;13)(F3;A3),dic(5;15)(A1;A1),+6, +6,idic(12)(A1;A1) clone 2 [25%]: 39,X,idem,idic(16)(A1;A1) clone 3 [30%]: 39,X,idem,idic(18)(A1;A1) clone 4 [20%]: 40,X,der(3)t(3;13)(F3;A3),dic(5;15)(A1;A1),+6,+6,idic(12)(A1;A1),der(13)t(3;13)(3::13::13::3)(3qter→3F3::13A3→13A1::CEN::13A1→13A3::3F3→3qter). clone 5 [5%]: 39,X,idem,idic(10)(A1;A1)	mFISH (wcps) mcb aCGH	metastatic skin MMa	{8; 0}
S91 clone M3	79–87<4n>,XXXX,+der(1)t(1;2)(pter→1G3:1C4→1G3:2E5→2qter),del(2)(C2E5),der(2)t(1;2)(G3;E5), del(4)(D1E2),del(4)(D3E2),del(5)(E4G2),dup(6)(F2∼3B2∼C1),–7,+inv(8)(A2B2∼3),del(9)(A4E3),inv(10)(B1D3),inv(10)(B1D3),+der(12)t(10;12)(C1A1),del(11)(B3D),+der(12)t(10;12)(D1C1),idic(13)(19qter→19C2:13A3→13A1:13A1→13A3:19C2→19qter), +15,–19,+mar(?)t(?;11E2)	mFISH (wcps) mcb aCGH	aggressive or advanced/maybe metastatic MMa from skin and eye	{12}
malignant mesothelioma (MMe)
AB1	73~80<4n>,-X,-X,der(1)t(1;2)(H5;F1), der(1)t(1;2)(H5;F1),+der(1)t(1;2)(C1;F1),-2,der(2)(2A1→ 2H4::6F3~G1→6E1::6F3~G1→6qter),der(2)(2A1→ 2H4::6F3~G1→6E1::6F3~G1→6qter),der(2)t(2;19) (E3;D1),+3,der(6)t(2;6)(H1;E1),der(6)t(2;6)(H1;E1),der(7) t(7;19)(E3;D1),dic(9;19)(A1;D3),dic(9;19)(A1;D3),del(13) (A5),dic(13;17)(A1;A1),dic(13;17)(A1;A1),der(15)t(15;?) (E1?;?),+der(15)(15pter→15E1::17B→17E3::17E3→17B:), +der(15)(15pter→15B2::17B→17E3::17E3→17B:),-16,-17, -17[11],-18[10],del(19)(D1),del(19)(D1)	mFISH (wcps) mcb aCGH	epithelioid MMe	{7}
AB22	73~79<4n>,-X,-X,der(X)t(X;6)(C~D;C1),der(X)(XA1→XC~D::6C1→6G2::XF1→Xqter),dic(3;3)(A1;A1),del(3)(A3F1),der(4)(4A1→4C3::4C3::4C5→4C7::4C7→4C5::2F3→2qter), der(4)(4A1→4C3::4C3::4C5→4C7::4C7→4C5::2F3→2qter), -5,der(5)t(5;11)(G2;D~E),der(6)t(X;6)(D;C1),der(6)t(X;6) (D;C1),der(7)t(7;9)(F4;F1),der(7)t(7;9)(F4;F1),-10,-12,- 13,-14,der(15)t(5;15)(G2;E),der(15)t(5;15)(G2;E),der(15)(15pter→15E::6D→6E::15E→15qter),+der(15)(15A1→ 15E::6D→6E::15E→15qter),+der(15)(15pter→15E::6D →6E::15E→15qter),del(16)(B2),der(16)(pter→B2::B1→qter),inv(17)(CE5),inv(17)(CE5),-18,+19.	mFISH (wcps) mcb aCGH	epithelioid MMe	{7}
AC29	main clone [90%]:63<3n>,X,-X,der(X)(pter→A1::A2→qter),der(1)(pter→D::E4→G::H2→qter),der(1)(pter→C5::C2→qter),del(2)(E2E5),der(2)(2pter→2H3::19C3→19D2::11D→11qter),+del(3) (A3E3),+del(3)(A3E3),+del(4)(C4),der(5)t(5;6)(B;B3), -6,der(6)t(6;12)(G1;C2),+der(8)(8pter→8A3::8B3→8E2: :18D→18E4::1E4→1G::18D→18E4::1E4→1G::18E4→ 18D::1E4→1G),dic(9;15)(A1;A1),del(11)(B4E1),der(11) (pter→B4::A2→qter),der(11)t(2;11)(H3;D),der(12)t(6;12) (G1;C2),del(13)(A5B),der(17)t(11;17)(D;E5),der(17)(17pter→ 17B~C::6B1→6G3::6B1→6G3::17B~C→17E5::2H3→2qter), der(17)(17pter→17E5::17E4→17E5::11E1→11qter),der(18) t(5;18)(B1;D3),del(18)(B1C),+mar1,+mar2 subclone [10%]: as main clone but der(13)t(13)t(12;13)} instead of del(13)(A5B)	mFISH (wcps) mcb aCGH	epithelioid MMe	{7}
AE17	putative stem line [10%]: 40,inv(X)(qF1qF5),inv(X)(qDqF4),t(3;5)(qE1;qE3),del(4)(q C3),del(7)(qD1qE1),10cen-,del(12)(qA3qC1),del(14)(qD2 qE2.3),del(15)(qA1→qA2::q B1→qD1::qD2→qter),inv(18)(qDqE4) clone 1 [63%]: 41,idem,+10cen- clone 2 [10%]: 41,idem,+6 clone 3 [17%]: 40,idem,t(12;17)(qC3;qB),ins(18)(qA1→qD::cenh::qD→qter)	mFISH (wcps) mcb aCGH	sarcomoid MMe	{2}
salvary gland tumor (SGT)
WR21	clone 1 [17%]: 44,XY,+Y,+inv(4)(A1C4),+8,der(9)(A1→E2::E1 → qter),der(12)(A1→F2::F1→qter),+19 clone 2 [77%]: 43,XY,+Y,inv(4)(A1C4),+der(4)t(4;8)(:4C4→4A4::8A1→8E2),+19 clone 3 [6%]: 43,XY,+del(Y),inv(4)(A1C4),+der(4)t(4;8)(:4C4→4A4::8A1→8E2),+19	mFISH (wcps) mcb aCGH	myoepithelioma SGT	{5}
SCA-9	62~76,XX,-1,-2,idic(4)(A1;A1),del(4) (C1),del(4)(C1),der(5)(A1→G3::G3→G2:),der(5)t(5;8) (5A1→5G3::5G3→5G2::8B1→8E2),+6,-7,-8,-8,-9,-12,- 12,-13,der(14)t(14;8)(C1;A1)x2, der(18)t(18;12)(D;E),-18	mFISH (wcps) mcb aCGH	mucoepidermoid or myoepithelioma SGT	{5}
testis tumor
I-10	43<2n>,der(X)t(X;16)(XA1→XE1::XE3→Xqter::16B4),-Y,idic(1)(A1),der(1)t(1;16)(C5;B4),t(3;9)(H4;F2),+del(4)(D2),der(5)t(5;17)(G2;C),+del(6)(B2),+del(6)(B2),del(7)(A3),+dic(7;17)(A;A),del(9)(A5B),+dic(10;13)(10qter→10C1::10A3→10A1::13A1→13qter),neo(12)(C1→qter),+der(12)t(12;15)(12pter→C1::15B→15D3::15E3→15qter), der(13)t(13;14)(C1;A3),-14,del(18)(A1B1)	mFISH (wcps) mcb aCGH	early human testicular germ cell tumor	{15}
MLTC-1	72-105<6n>,XX,-Y,-Y,dic(1;1)(A1;A1), der(2)t(2;9)(E5;C),+del(2)(A2E5),+der(2)(pter→B::A1→B),der(3)(3pter→3A1::3F1→3G::14E2→14qter), der(3)(pter→A1::F1→G:),del(4)(A1A5),del(4)(A1A5), del(4)(A1A5),del(5)(E5),-5,-5,dic(6;6)(A1;A1),del(6) (D),-7,-7,-9,dic(11;12)(12qter→12E::12F2→12A1→ 12A1::11A1→11E2::17B→17qter),neo(11)(E1→qter),-11, -11,der(12)(pter→A3::B→qter),-12,-12,-13,-13, dic(15;15)(A1;A1),+15,+15,der(17)t(17;18)(B1;E1),-18,-18,der(19)t(6;19)(A1;D1),-19,-19,-19	mFISH (wcps) mcb aCGH	advanced testicular tumor, maybe also advanced Leydig cell tumor	{16}

Human cell lines

name	karyotype	methods	human cancer	Reference
chordoma
U-CH1	40-43,XY,der(1)t(1;22),del(4),+del(5), +del(6),+7,del(9),del(10),+der(20)t(10;20),+21/ 72-79,XXY,+Y,+1,der(1)t(1;22)x2,-3,+del(4), +5,del(5)x2,+6,del(6)x2,+7,+7,+7,?del(8), +8 or +?del(8),del(9),+10,del(10)x2,-11,-12, -14,+15,-17,-18,-19,der(20)t(10;20),+21,-22	MFISH (wcps)	chordoma	{17}
colon cancer
AGP01	63,XX,inv(1)(p12q43),der(1)(1pter→1p12::1q43→1p12::9p12→9pter),+der(1)t(1;12)(q21;q12),+del(1)(p12),+del(2)(p12),+der(2)t(2;8)(p12;q11.2),inv(3)(p21q13)x2,+inv(3)(p21q13),+der(3)t(3;5)(p14;q13),t(4;14)(p12;q11.2),dic(4;12)(p15;q12),+der(4)t(2;4)(p or q?;q12),del(5)(p13)x2,+der(5)x2,del(6)(q12)x2,+del(6)(p21),inv(7)(p12;q11.2),der(7),der(9)t(9;acro)(p21;p12),der(9)t(6;9)(p12;p12),t(13;13)(p10),der(15)(:q13→p11::p11→qter),-15,der(16)t(X;16)(q or p?;q23),+der(16)t(12;16)(q12;q23),21p+,t(22;22)(p10)	MFISH (wcps)	gastric cancer	{28}
HCT116 p53 +/+	45<2n>,X,-Y,dup(10)(q?q?),der(16)t(8;16)(p13;?),der(18)t(17;18)(?q;p11.2)	MFISH (wcps)	colon carcinoma	{23}
HCT116 p53 −/−	45<2n>,X,-Y,t(5;7)(q1?3;p22),dup(10)(q?q?),der(16)t(8;16)(p13;?),der(18)t(17;18)(?q;p11.2)	MFISH (wcps)	colon carcinoma (drug resistant)	{23}
HT-29 Clone 19A	64~69,XX,del(X)(p11.2),-1,del(1)(p35),+der(2)t(1;2)(q32;q11),-3,-3,i(3)(q10),der(3)ins(3;12)(p12;p12p12),-4,der(4)t(2;4)(q35;q11),+der(5)t(5;6)(q11;q26),+der(5)t(5;19)(q11;q11),-6,der(6;9)t(6;9;X;9)(6pter→6q10::9q10→9q21::Xp21.1→Xp11.3::9q21→9qter), -7,del(7)(p15),+idic(7)(q11.2),-8,-8,der(8)i(8)(qter3q10::q103q24::hsr::q243qter), -9,+del(11)(p13),+der(11)t(11;20)(q24;q11.2),-13,-13,-13,i(13)(q10),i(13)(q10),der(13)i(13)(q10)t(5;13)(q31;q21),-14,-16,del(16)(q13),-17,der(17)t(17;19)(p11;p11),-18,i(18)(p10),-19,-19,+20,-21,+der(22)t(17;22;17)[cp10]	MFISH (wcps) MCB	colon adenocarcinoma	{19}
LT97	clone 1 [50%]: 46~50,XX,+i(1)(q10),+der(7)t(7;17)(q31.3;q21.3) clone 2 [50%]: 44~46,XX,+dic(1;18)t(q10:qter;q10:qter), der(7)t(7;17)(q31.3;q21.3),-18.	MFISH (wcps)	colon adenocarcinoma	{20}
SW480	57,XX,t(1;9)(q21.1;q12),+der(2)t(2;12)(q34;q12),del(3)(q12.1),+der(3)t(3;10)(p24;p12),del(5)(q22),+der(7)dup(7pter→7q36.?3::7q31.3→7qter),+der(7)t(7;14)(q31;q21),der(8)t(5;8)(q?;q21.1),-9,+dic(8;9)(p11;p11),-10,-12,+dic(10;12)t(3;10;12)(3qter→3q13.3::12p11→12q11: :10p14→10qter),+11,+der(13)t(3;13)(p23;q21),+17,+dic(15;18)(15pter→15q11::18p11→18q21.1)x2,i(18)(p10),der(19)t(6;19)(q22;q13.1),+der(20)t(5;20)(q22;p13)x2	MFISH (wcps) mMCB cenM-FISH	colorectal cancer	{21}
endothelial
hCMEC/D3	45~48,XX,-X,del(5)(q11)[2],del(9)(q11)[3],+9[3],del(11)(q13 14)[2],der(14)t(14;21)(q32.33;q22.3)[28],der(15)t(9;15)(p11;p11)[13],dup(15)(p11q11)[5], der(21)t(17;21)(p12;q22)[9],-22[6][cp28].	MFISH (wcps) mMCB	cerebral microvessel endothelial	{25}
head and neck cancer
BICR10	38~44,X[29],-1[30],der(2)t(1;2)(q21;p23)[30],der(2)t(1;2)(p13;q21)[28],+der(2)t(1;2)(p13;q21)[2],der(3)t(3;7)(p10;p10)[25],+der(3)t(3;7)(p10;p10)[3],-4[24],-4,-4[3],+4[3],-5[7],+5[1],der(5)t(3;5)(p13;p15)[27],-6[2],-7[19],der(7)t(7;11)(q21.3;q11.1)[24],+der(7)t(7;11)(q21.3;q11.1)[4],-8[5],der(8)t(5;8)(q13;q24)[25],der(8)t(8;8)(q10;q?)[24],+der(8)t(8;8)(q10;q?)[2],-9[6],+9[4],del(9)(p22)[24],-10[5],-11[27],der(11)t(7;11)(p10;p10)[28],+der(11)t(7;11)(p10;p10)[2],-12[2],-13[22],+13[3], der(13)t(11;13)(q13;q10)[4],-14[24],der(14)t(7;14)[3],-15[2],der(15)t(X;15)(q10;q10)[27],-16[7],-17[9],der(17)t(7;17)(q10;q10)[21],der(18)t(14;18)(q10;q10)[24],der(18)t(17;18)[23],+19[3],-20[7],-21[4],-22[11],+mar1[30],+mar2[10],+ma r3[3][cp30]	MFISH (wcps) mMCB	head and neck squamous cell carcinoma	{29}
HSC-3	58~63,der(X)t(X;1)[28],der(X)t(X;8)[29],der(X)t(X;11)[1],der(X)(12::12?::1::X::13)[1],Y,-Y[1],del(1),del(1)[1],del(1)[1],der(1)(1::11::X::11)[27],der(1)(1::11::X::11::2)[1],der(1)(1::10::3)[1],dic(1;5)(5::?::12::1)[1],-2,-2[1],der(2)t(2;11)[1],t(2;3)[1],+3[1],der(3)t(1;3)[29],der(3)(1::3::1)[1],der(3)t(3;11)[29],+der(3)t(3;18),dic(3;5)(5::12::7?::4::11::3)[1],+der(3)t(X;3)[1],der(4)t(4;6)[29],+der(4)t(4;6)[1],der(4)t(4;9),der(4)t(4;?)[1],del(4)[1],-5[2],der(5),del(5)[1],del(5)[1],+der(5)t(5;12)[2],+der(5)(5::12::9)[1],+der(5)(5::16::12)[1],+der(5)(5::16::12::16?)[1],+der(5)(5::16::12::5)[1],+der(5?)(5?::12::7?::12::8)[1],+der(5?)(5?::12::?::5)[1],+der(5)(5::12::7?::12)[1],+der(5)(5::12::7::12::5)[1],+der(5)(5::?::12::2)[1],+der(5)(5::12::16?::12::2)[1],+der(5)(5::12::7::12::14?)[1],-6,der(7)t(7;14)[29],dic(7;22)[28],dic(7;22)(20::7::22)[1],dic(7;12)(7::14::13::12::7?::12::17)[1],der(7)t(7;13)[1],der(7?)t(5;7)[1],-8,-8[2],t(8;10)[1],-9[1],der(9)t(9;14)[1],idic(9)(q10)[29],del(9)[1],del(9)[1],del(10),der(10)t(Y;10)[1],-11[1],der(11)(5::11::4::10)[29],der(11)(5::11::4::10::5)[1],der(11)t(11;22),dic(12;13)(13::12::7::12::17)[28],der(12)t(8;12)[1],idic(13;13)[29],dic(13;13)(13::13::7)[1],der(13)(5or12::11::16::11::8or17::13)[27],der(13)(5or12::11or17::16::8or17::13::X)[1],der(13)(11::12::11:16::11?::13)[1],14p+?,der(14)t(14;?),der(14)t(5;14)[1],der(14)(2::4::2::4::14)[27],-15,der(15)t(8;15),-16,der(16)t(7;16),der(17),der(17)[1],-18,-18,-19,+20[28],-21,der(21)t(18;21),der(21)t(5;21)[1],-22[1],del(22),der(?)(?::X::11)[1],der(?)(?::11::X::11)[1],+mar[29],+mar[1][cp30]	MFISH (wcps) aCGH	tongue derived squamous cell carcinoma (SCC)	{27}
leukemia
CCRF CEM	clone 1 [85%]: 47,XX,der(5)t(5;14)(q35.33;q32.3),t(8;9)(p12;p24),del(9)(p14.1),+20 clone 2 [15%]: 46,X,-X,der(5)t(5;14)(q35.1;q32.3),del(9)(p14.1), +20	MFISH (wcps) CGH	T-cell acute leukemia	{26}
CCRF CEM1	42~47,X,enh(3q13),der(5)t(5;15)(q35;?),del(8)(pter),del(9)(p13pter),der(9)t(8;9),+13,der(15)t(5;15),del(18)(q23qter),+20[cp12]	MFISH (wcps) CGH	drug-resistant T-cell acute leukemia	{18}
CCRF CEM2	93~96,XX,del(1)(q?),der(3)t(1;3)(p33;q24),der(4)t(4;5)(p13;q21),del(5)(q21qter),del(6)(p21pter), enh(6p21q25),+der(7)t(7;11)(p11;?),del(8)(p),-9,del(9)(p13pter),der(9)t(8;9)(p;?)x2,-13,del(13)(q31qter),+idic(13)(q31), der(17)t(6;17)(q25;q21),del(18)(q23qter),+19,+20,+21,+22[cp4]	MFISH (wcps) CGH	drug-resistant T-cell acute leukemia	{18}
CEM/ADR5000 in 2002	47,X,-1,-1,+i(1)(p),+i(1)(q),del(3)(q26.3qter),del(4)(q31q34),enh(5p),der(5)t(5;15)(q35;?),enh(7)(p21pter),del(8)(p?),del(9)(p13pter)der(9)t(8;9)(p;q31),+13,der(15)t(5;15),del(18)(q22.3qter),+20,del(22)(q?)[cp4]	MFISH (wcps) CGH	drug-resistant T-cell acute leukemia	{18}
CEM/ADR5000 in 2016	clone 1 [19%]: 47,X,-X,t(3;10)(q11.2~12;p14~15),der(3)t(3;13)(q26.32;q22.3),del(4)(q31.32q34.3),der(5)t(18;5;14)(18qter→ 18q21.2::5p12→5q35.33::14q32.3→14qter),inv(7)(p21.1q21.1), t(8;9)(p12;p24),del(9)(p14.1),t(10;16)(q23.31;q22 ~ 23),del(14) (q32.3),der(18)t(7;18)(p21;q21.2),der(18) (21qter→21q22.1::18p11.22→18q12.1::5p12→5pter), der(18)(21p?::21q22.3→21q22.1::18p11.22→18q12.1::5p12→5pter),+20, der(22)t(9;22)(q22.33;q13.33) clone 1a [20%]: 47,idem,t(6;14)(q26;q32.33) clone 1b [26%]: 47,idem and translocation between one chromosome 20 and a derivative chromosome der(10) t(3;10) clone 1b1 [30%]:with the same additional aberration as clone 1b and an additional translocation between a chromosome 17 and der(18)(21;18;5) clone 1c [5%]: with a translocation t(6;20;8)(q24;q11.2~1;q22.3~23) and loss of the derivative chromosome der(18) (21qter→21q22.1::18p11.22→18q12.1::5p12→5pter).	MFISH (wcps) CGH	drug-resistant T-cell acute leukemia	{26}
CEM/MTX60	80~83,XX,del(1)(p?),del(3)(p?)x2,+der(3)t(1;3)(p33;q13), -4,del(5)(p?),amp(5q13),-6,-7,del(8)(p?),-9,del(9)(p21pter),der(9)t(8;9)(q22;?)x2,-12,-13,-13,+14,-15,+17,-18,del(18)(q23qter),-19,+20,-21,+22[cp7]	MFISH (wcps) CGH	drug-resistant T-cell acute leukemia	{18}
CEM/MTX140	91~93,XX,del(1)(p31)x2,der(3)t(1;3)(p31;q24),der(4)t(4;14)(p15;q21),hsr(5)(q13q14),der(5)t(5;19)(q31;?),+der(6)t(6;21)(q;q),+der(7)t(7;17)(q22~32;q?),del(8)(p?)x2,del(9)(p13pter),der(9)t(8;9)x2,-13,-13,+i(13)(q),der(15)t(15;22),del(18)(q23qter),+20,+del(20)(p?),+22[cp5]	MFISH (wcps) CGH	drug-resistant T-cell acute leukemia	{18}
CEM/MTX1500	90~94,XX,del(1)(p?),der(3)t(1;3)(?;q13),+der(4)t(4;14)(q32;q?),hsr(5)(p13p15.2&q11q13),del(5)(q35qter),der(5)t(5;22)(q35;q),+del(6)p11.2),enh(6q),+der(7)t(7;17),del(8)(p?)x2,del(9)(p21pter)x2,der(9)t(8;9)x2,der(11)t(11;17), -13,der(14)t(5;14)(q35?;q),-17,-18,-19,+20,del(20)(p)[cp5]	MFISH (wcps) CGH	drug-resistant T-cell acute leukemia	{18}
CEM/MTXR1	92~94,XX,der(1)t(1;8)x2,der(4)t(4;12)x2,der(4)t(4;5;4) hsr(5)(q13q15)x2,-7,del(8)(p?)x2,der(8)t(1;8)x2, del(9)(p13pter)x2,der(9)t(8;9)x2,+20,+20,der(21)t(8;21)x2[cp3]	MFISH (wcps) CGH	drug-resistant T-cell acute leukemia	{18}
CEM/MTXR2	89~95,XX,del(X)(q?),der(1)t(1;8)x2,del(2)(q?), der(4)t(4;5;4)p;?;q27),der(4)t(4;5;4;5) hsr(5)(q13 q14),+der(4) t(X;4)q22;q27),hsr(5)(q13 q14)x2, del(5)(q?),del(8)(p?)x2,der(8) (1;8)x2,-9, del(9)(p13pter),der(9)t(8;9)x2,enh(13)(q21q32),+20, +20,der(21)t(8;21)x2[cp3]	MFISH (wcps) CGH	drug-resistant T-cell acute leukemia	{18}
CEM/MTXR3	81~94,XX,der(1)t(1;8)x2,der(1)t(4;5;4;5;1)der(2)t(2;9;8),del(3)(q25qter),der(4)t(4;5;4)(p;?q)der(4)t(4;5;4;5;4;5), +der(4)t(X;4)(q22;q?),hsr(5)(q13q15)x2,del(8)(p?)x2,der(8)t(1;8)x2,del(9)(p13pter),der(9)t(2;9), i(9q),t(8;9),-18,-19,der(21)t(8;21)x2[cp6]	MFISH (wcps) CGH	drug-resistant T-cell acute leukemia	{18}
CEM/VCR1000	48~50,X,del(1)(p36.5pter),del(5)(q35),enh(6)(q13q23), +7,del(8)(p?),del(9)(p13),i(9)(q?),+13,+20,+21,del(22)(q?)[cp3]	MFISH (wcps) CGH	drug-resistant T-cell acute leukemia	{18}
KCL22-R	clone 1 [80%]: 48~51,X,X,+der(1)t(1;10)(p13;?),+der(6)t(6;13)(p11.1;q12),+8,+der(8)t(8;21)(p21;q?),der(9)t(9;22)(q34;q11),-13, der(17)t(17;19),22,+der(22)t(9;22)(q34;q11)x2 clone 2 [20%]: 49~50,XX, idem,der(6)t(6;13)(p11.1;q12), +der(6)t(3;13;6)(?;p12;p11.1) *see paper for subclones of der(6)	MFISH (wcps) MCB	Imatinib-resistant chronic myeloid leukemia	{24}
KCL22-S	48~51,X,X,+der(1)t(1;10)(p13;?),+6,+der(8)t(8;21)(p21;q?),der(9)t(9;22)(q34;q11),der(17)t(17;19),-22, +der(22)t(9;22)(q34;q11)x2	MFISH (wcps)	Imatinib-sensitive chronic myeloid leukemia	{24}
lymphoma
GRANTA-519	clone 1: 44,XX,-1,inv(1)(p32p36.3),t(1;12)(q21.2~q22;q24.1),der(1)t(1;14)(p36.3;q11)del(1)(p31p13),der(3;18)(q10;q10),-8,-9,dic(9;12)(p13;p11),-11,der(11)t(11;14)(q13;q32), -12,del(12)(q24.1),-13,der(13)t(1;13)(q21.2;p13),-14,der(14)t(11;14) (q13;q32),-17,der(17)t(17;20)(p11;q11)del(17)(q21q24),18,hsr(18)(q21),+mar clone 2: idem but one normal chromosme 14 replaced by der(14) clone 3: hypotetraploid version of the major cell clone	MFISH (wcps) CGH	mantle cell lymphoma	{22}
trophoblast
AC-1M59	89~94<4n>,XXY,del(X)[10],+3[5],der(4)t(4;9)[7],der(4)t(4;15)[2],der(4)t(4;16)[2],del(4)[2],+5[7],+del(5)[6],-6[3],der(7)t(7;10)[5],+der(7)t(7;10)[6],+der(7)t(7;21)[8],-8[9],der(8)t(5;8)[8],+der(9)t(4;9)[10],+der(10)t(6;10)[5],der(10)t(10;15)[5],der(10)t(9;10)[2],-11[6],-13[8],-13,der(13)t(13;13)[7],+ins(14;?)[7],del(15)[2],der(15)t(10;15)[3],-18[7],-18[3],del(18)[2],-19[6],+21[5],+mar1[4],+mar2[3][cp10]	MFISH (wcps)	trophoblast	{30}
ACH-3P	75~104<4n>,XY,del(X)[9],del(1)[5],+2[4],+der(2;5)[5],-4[10],-4[7],der(4)t(4;9)[8],+5[4],+del(5)[9],-6[6],-7[7],der(7)t(7;10)[3],-8[9],+der(9)t(4;9)[7],der(9)t(4;11)[5],der(10)t(10;16)[10],-11[8],-13[6],der(13)t(13;13)[8],+14[3],+ins(14;?)[9],der(15)t(10;15)[8],+16[5],-18[6],der(19)t(5;19)[6],+21[5][cp10]	MFISH (wcps)	trophoblast	{30}
BeWo	67~73<3n>,XYY,+der(X)t(X;5)[9],+del(X)[9],+der(1)t(1;11)[10],der(1)t(1;1)[9],+del(2)[3],+3[7],+del(4)[4],+5[5],+del(5)[4],+6[3],+7[5],-8[4],+del(12)[4],der(13)t(13;13)[7],+14[6],der(15)t(4;15)[7],+del(16)[7],der(19)t(5;19)[5],+21[7],+der(22)t(9;22)[4][cp11]	MFISH (wcps)	trophoblast	{30}
HTR8/SVneo	61~66<3n>,X,der(X)t(X;2)[13],del(X)(q11.2)[11],der(X)(:p?21->q11.2:)[10],der(1)(8?pter->8?p12::1?p11->1q21:)[13],-4[13],+der(5)t(5;8;14;8)x2[14],-6[13],der(7)t(7;18)[12],-8[13],del(8)(p1?2)[11],-9[12],der(9)t(4;9)[15],der(10)t(10;16)[14],del(10)(p22)[10],+der(10)t(1;10)[11],-12[15],-13[14],-14[8],-15[12],der(16)t(16;8;12)[15],der(16)t(16;19)[15],+der(17)t(14;17)[10],der(17)t(X;17)[5],der(17)t(X;17;8;14;8;20)[11],-18[15],-19[11],der(20)t(20;8;6;2)[14],der(22)t(22;21;4;19;18;9;15)[14][cp15]	MFISH (wcps)	trophoblast	{30}
JAR	67~73<3n>,XY,der(X)t(X;4)[18],+del(1)(q11)[17],der(1)t(21;1;16)[19],del(2)[3],der(2)t(2;21)[2],del(3)[16],der(3)t(2;3)[14],der(3)t(11;3;4)[16],-4[8],der(4)t(5;4;17)[12],der(4)t(X;4)[5],+del(5)[16],der(5)t(5;9)[14],der(5)t(5;21)[2],-7[4],der(7)t(6;7)[2],der(7)t(9;7;16)[5],der(7)t(8;7;4)[4],+der(8)t(4;8)[2],+der(8)t(5;8)[13],der(8)t(8;12)[2],der(8)t(8;14)[4],der(8)t(8;17)[3],der(9)t(5;9)[3],der(9)t(7;9)[17],der(9)t(8;9)[3],+der(9)t(9;14)[18],-10[14],-11[15],i(12)(p11.1)[7],der(12)i(12)(p11.2)t(12;21)[5],-13[19],i(13)(q10)[18],ins(14)(14;?)[8],der(14)t(5;14)[2],der(14)t(8;14)[2],+der(14)t(11;14)[2],+der(14)t(12;14)[5],-15[7],der(17)t(17;22)[5],-21[12],der(21)t(10;21)[16],der(21)t(12;21)[6],-22[15][cp19]	MFISH (wcps)	trophoblast	{30}
JEG-3	59~80<3n>,XY,-X[6],del(X)[7],+1[4],+der(1)t(1;9)[4],+der(1)t(1;18)[5],+2[9],+3[11],der(4)t(4;11)[12],+5[7],-7[12],der(7)t(7;10)[11],-8[11],+9[8],der(10)t(10;16)[14],-11[14],+12[6],-13[14],-13[11],ins(14;?)[8],der(15)t(10;15)[12],-18[8],der(19)t(5;19)[13],+20[4],+22[10],+mar1[12],+mar2[4][cp14]	MFISH (wcps)	trophoblast	{30}

set up using free programm https://seamonkey.at//start

How to cite this database:- Liehr T. 2024. Detailed karyotypes of tumor cell lines. https://cs-tl.de/DB/TC/CLs/0-Start.html [accessed on ...]

How to cite this database:-
Liehr T. 2024. Detailed karyotypes of tumor cell lines.
https://cs-tl.de/DB/TC/CLs/0-Start.html [accessed on ...]