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ChromosOmics - Database
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- mFISH - whole chromosome paints (wcps)
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TUMOR CYTOGENETICS
mFISH with whole chromosome paints as
probes is extensively applied in tumor cytogenetics.
For review see e.g.:
- Bayani JM, Squire JA
(2002) Applications of SKY in cancer cytogenetics.
Cancer Invest 20:373-386.
- Calasanz MJ, Cigudosa JC
(2008) Molecular cytogenetics in translational
oncology: when chromosomes meet genomics. Clin
Transl Oncol 10:20-29
- Nowell PC, Rowley JD,
Knudson AG Jr (1998) Cancer genetics,
cytogenetics--defining the enemy within. Nat Med
4: 1107-1111
(molecular) cytogenetics is necessar for
tumorcytogenetic diagnostics
- Granada I, Palomo L,
Ruiz-Xivillé N, Mallo M, Solé F (2020)
Cytogenetics in the genomic era. Best Pract Res
Clin Haematol 33: 101196.
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Leukemia
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- Abe S, Ishikawa I, Harigae
H, Sugawara T (2008) A new complex translocation
t(5;17;15)(q11;q21;q22) in acute promyelocytic
leukemia. Cancer Genet Cytogenet 184:44-47.
- Abdelhaleem M, Shago M,
Sayeh E, Abla O (2007) Childhood myeloid/natural
killer precursor acute leukemia with novel
chromosomal aberrations der(5)t(4;5)(q31;q31.3) and
t(14;17)(q32;q23). Cancer Genet Cytogenet
178:141-143.
- Ahuja HG, Popplewell L,
Tcheurekdjian L, Slovak ML (2001) NUP98 gene
rearrangements and the clonal evolution of chronic
myelogenous leukemia. Genes Chr Cancer 30: 410-415.
- Al Achkar W, Wafa A,
Mkrtchyan H, Moassas F, Liehr T (2010) A rare case
of chronic myeloid leukemia with secondary
chromosomal changes including partial trisomy 17q21
to 17qter and partial monosomy of 16p13.3. Mol
Cytogenet 3:6.
- Al Achkar W, Wafa A, Ali
BY, Manvelyan M, Liehr T (2010) A rare chronic
myeloid leukemia case with Philadelphia chromosome,
BCR-ABL e13a3 transcript and complex translocation
involving four different chromosomes. Oncol Lett
1:797-800.
- Al Achkar W, Wafa A,
Mkrtchyan H, Moassass F, Liehr T (2010) A rare case
of Philadelphia chromosome-positive chronic
myelogenous leukemia with inversion in chromosome 9
and t(10;17). Oncol Lett 1:793-795.
- Andersen MK, Christiansen
DH, Pedersen-Bjergaard J (2005) Centromeric breakage
and highly rearranged chromosome derivatives
associated with mutations of TP53 are common in
therapy-related MDS and AML after therapy with
alkylating agents: An M-FISH study. Genes Chr Cancer
42: 358-371.
- Avet-Loiseau H, Daviet A,
Brigaudeau C, Callet-Bauchu E, Terre C,
Lafage-Pochitaloff M, Desangles F, Ramond S, Talmant
P, Bataille R (2001) Cytogenetic, interphase, and
multicolor fluorescence in situ hybridization
analyses in primary plasma cell leukemia: a study of
40 patients at diagnosis, on behalf of the
Intergroupe Francophone du Myelome and the Groupe
Francais de Cytogenetique Hematologique. Blood 97:
822-825.
- Babicka L, Zemanova Z,
Pavlistova L, Brezinova J, Ransdorfova S, Houskova
L, Moravcova J, Klamova H, Michalova K (2006)
Complex chromosomal rearrangements in patients with
chronic myeloid leukemia. Cancer Genet Cytogenet
168:22-29.
- Bacher U, Haferlach T,
Schoch C (2005) Gain of 9p due to an unbalanced
rearrangement der(9;18): a recurrent clonal
abnormality in chronic myeloproliferative disorders.
Cancer Genet Cytogenet 160: 179-183
- Bacher U, Haferlach T, Kern
W, Harich HD, Schnittger S, Haferlach C (2007) A
case of chronic myeloproliferative syndrome followed
by precursor T-cell acute lymphoblastic leukemia.
Cancer Genet Cytogenet 175:52-56.
- Bacher U, Haferlach C
(2008) FISH in the diagnosis of hematological
neoplasias. Medgen 20: 367-373. (German)
- Bai S, Xue Y, Wu Y, Pan J,
Zhang J, Shen J, Wang Y, Qiu H (2008) [Simultaneous
presence of ins (15;17),t(2;17;20) and trisomy 8 in
a patient with acute promyelocytic leukemia.]
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:712-714.
Chinese.
- Bakshi SR, Patel BP,
Brahmbhatt MM, Trivedi PJ, Gajjar SB, Iyer RR,
Parikh EH, Shukla SN, Shah PM (2009) Complex
karyotype with a masked Philadelphia translocation
and variant BCR-ABL fusion in CML. Cancer Genet
Cytogenet 189:142-143.
- Barber KE, Ford AM, Harris
RL, Harrison CJ, Moorman AV (2004) MLL
translocations with concurrent 3' deletions:
interpretation of FISH results. Genes Chromosomes
Cancer 41:266-271.
- Barbouti A, Johansson B,
Hoglund M, Mauritzson N, Strombeck B, Nilsson PG,
Tanke HJ, Hagemeijer A, Mitelman F, Fioretos T
(2002) Multicolor COBRA-FISH analysis of chronic
myeloid leukemia reveals novel cryptic balanced
translocations during disease progression. Genes
Chromosomes Cancer 35: 127-137.
- Barouk-Simonet E,
Soenen-Cornu V, Roumier C, Cosson A, Lai JL, Fenaux
P, Preudhomme C (2005) Role of multiplex FISH in
identifying chromosome involvement in
myelodysplastic syndromes and acute myeloid
leukemias with complex karyotypes: a report on 28
cases. Cancer Genet Cytogenet 157:118-126.
- Batista DA, Vonderheid EC,
Hawkins A, Morsberger L, Long P, Murphy KM, Griffin
CA (2006) Multicolor fluorescence in situ
hybridization (SKY) in mycosis fungoides and Sezary
syndrome: search for recurrent chromosome
abnormalities. Genes Chromosomes Cancer 45: 383-391.
- Betts DR, Niggli FK, Cohen
N, Rechavi G, Amariglio N, Trakhtenbrot L (2008) SKY
reveals a high frequency of unbalanced
translocations involving chromosome 6 in
t(12;21)-positive acute lymphoblastic leukemia. Leuk
Res 32:39-43.
- Bezrookove V, van
Zelderen-Bhola SL, Brink A, Szuhai K, Raap AK, Barge
R, Beverstook CG, Rosenberg C (2004) A novel
t(6;14)(q25~q27;q32) in acute myelocytic leukemia
involves the BCL11B gene. Cancer Genet Cytogenet
149: 72-76.
- Brezinova J, Zemanova Z,
Ransdorfova S, Sindelarova L, Siskova M, Neuwirtova
R, Cermak J, Michalova K (2005) Prognostic
significance of del(20q) in patients with
hematological malignancies. Cancer Genet Cytogenet
160: 188-192
- Brizard F, Cividin M,
Villalva C, Guilhot F, Brizard A (2004) Comparison
of M-FISH and conventional cytogenetic analysis in
accelerated and acute phases of CML. Leuk Res
28:345-348
- Calabrese G, Fantasia D,
Franch PG, Morizio E, Stuppia L, Gatta V, Olioso P,
Mingarelli R, Spadano A, Palka G (2000) Spectral
karyotyping (SKY) refinement of a complex karyotype
with t(20;21) in a Ph-positive CML patient submitted
to peripheral blood stem cell transplantation. Bone
Marrow Transplant 26: 1125-1127.
- Calabrese G, Fantasia D,
Morizio E, Toro PM, Franchi PG, Fornaro A, Spadano
A, Stuppia L, Palka G (2003) Chromosome 11
rearrangements and specific MLL amplification
revealed by spectral karyotyping in a patient with
refractory anaemia with excess of blasts (RAEB).Br J
Haematol 122:760-763
- Capela de Matos RR, Ney
Garcia DR, Cifoni E, Othman MAK, Tavares de Souza M,
Carboni EK, Ferreira GM, Liehr T, Ribeiro RC, M
Silva (2017) MLGAS6 oncogene and reverse MLLT3-KMT2A
duplications in an infant with acute myeloid
leukemia and a novel complex hyperdiploid karyotype:
detailed high-resolution molecular cytogenetic
studies. Cytogenet Genome Res 152: 33-37.
- Chae H, Kim M, Lim J, Kim
Y, Han K, Lee S (2010) B lymphoblastic leukemia with
ETV6 amplification. Cancer Genet Cytogenet
203:284-287.
- Chen BA, Xia GH, Li JY,
Xiao B, Shao ZY, Chen NN, Gao C, Wu YJ (2006)
Detection of complex karyotype in a myelodysplastic
syndrome cell line (MUTZ-1) by metaphase
fluorescence in situ hybridization. Zhongguo Shi Yan
Xue Ye Xue Za Zhi 14:46-49
- Chen S, Xue Y, Zhang X, Wu
Y, Pan J, Wang Y, Ceng J (2005) A new human acute
monocytic leukemia cell line SHI-1 with
t(6;11)(q27;q23), p53 gene alterations and high
tumorigenicity in nude mice. Haematologica
90:766-775
- Chen LJ, Li JY, Xiao B, Zhu
Y, Liu Q, Pan JL, Qiu HR, Fan L, Zhang SJ, Lu RN, Xu
W, Xue YQ (2007) [Analysis of complex chromosomal
aberrations in patients with myelodysplastic
syndromes using multiplex fluorescence in situ
hybridization combined with whole chromosome
painting] Zhonghua Yi Xue Yi Chuan Xue Za Zhi
24:635-639. Chinese.
- Cigudosa JC, Odero MD,
Calasanz MJ, Sole F, Salido M, Arranz E,
Martinez-Ramirez A, Urioste M, Alvarez S, Cervera
JV, MacGrogan D, Sanz MA, Nimer SD, Benitez J (2003)
De novo erythroleukemia chromosome features include
multiple rearrangements, with special involvement of
chromosomes 11 and 19. Genes Chromosomes Cancer 36:
406-412.
- Cohen N, Trakhtenbrot L,
Yukla M, Mandor Y, Gaber E, Yosef G, Amariglio N,
Rechavi G, Amiel A (2002) SKY detection of
chromosome rearrangements in two cases of tMDS with
a complex karyotype. Cancer Genet Cytogenet 138:
128-132.
- Collado R, Hueso J, Cabello
AI, Oliver I, Egea M, Orero M, Miguel-Sosa A,
Cigudosa JC, Benitez J, Barragan E, Carbonell F
(2006) New translocations in a case of atypical
B-cell chronic lymphocytic leukemia: involvement of
ATM, MLL, and TP53 genes. Cancer Genet Cytogenet
169:176-178.
- Corral Mdel P, Villa O,
Alfaro EM, Alonso CN, Baro C, Felice MS, Rossi J,
Solé F, Gallego MS (2008) Complex chromosome 8;21
translocation with associated hyperdiploidy in acute
myeloid leukemia (FAB-M2). Pediatr Blood Cancer
50:651-654
- Cox MC, Panetta P, Lo-Coco
F, Del Poeta G, Venditti A, Maurillo L, Del Principe
MI, Mauriello A, Anemona L, Bruno A, Mazzone C,
Palombo P, Amadori S (2004) Chromosomal aberration
of the 11q23 locus in acute leukemia and frequency
of MLL gene translocation: results in 378 adult
patients. Am J Clin Pathol 122:298-306
- Crescenzi B, La Starza R,
Nozzoli C, Ciolli S, Matteucci C, Romoli S, Rigacci
L, Gorello P, Bosi A, Martelli MF, Marynen P,
Mecucci C (2007) Molecular cytogenetic findings in a
four-way t(1;12;5;12)(p36;p13;q33;q24) underlying
the ETV6-PDGFRB fusion gene in chronic
myelomonocytic leukemia. Cancer Genet Cytogenet
176:67-71.
- Dai H, Xue Y, Pan J, Wu Y,
Wang Y, Shen J, Zhang J (2007) Two novel
translocations disrupt the RUNX1 gene in acute
myeloid leukemia. Cancer Genet Cytogenet 177:120-124
- Dalley CD, Neat MJ, Foot
NJ, Burridge M, Byrne L, Amess JA, Rohatiner AZ,
Lister A, Young BD, Lillington DM (2002) Comparative
genomic hybridization and multiplex-fluorescence in
situ hybridization: an appraisal in elderly patients
with acute myelogenous leukemia. Hematol J 3:290-298
- Davidsson J, Paulsson K,
Johansson B (2005 Multicolor fluorescence in situ
hybridization characterization of cytogenetically
polyclonal hematologic malignancies. Cancer Genet
Cytogenet 163:180-183.
- de Jesus Marques-Salles T,
Mkrtchyan H, Pereira Leite E, Soares-Ventura EM,
Cartaxo-Muniz MT, Ferreira E, Liehr T, Macedo Silva
ML, Santos N (2010) Complex karyotype defined by
FISH and M-FISH studies in an infant with acute
megakarioblastic leukemia and neurofibromatosis.
Cancer Genet Cytogenet 200: 167-169.
- de Oliveira FM, Tone LG,
Simoes BP, Falcao RP, Brassesco MS, Sakamoto-Hojo
ET, dos Santos GA, Marinato AF, Jacomo RH, Rego EM
(2007) Acute myeloid leukemia (AML-M2) with
t(5;11)(q35;q13) and normal expression of cyclin D1.
Cancer Genet Cytogenet 172:154-157.
- de Oliveira FM, Tone LG,
Simões BP, Rego EM, Marinato AF, Jácomo RH, Falcão
RP (2009) Translocations t(X;14)(q28;q11) and
t(Y;14)(q12;q11) in T-cell prolymphocytic leukemia.
Int J Lab Hematol 31:453-456.
- de Oliveira FM, Falcão RP,
de Figueiredo Pontes LL, Simões BP, Tone LG (2008)
Insertion (15;14)(q22;q13q32) in a case of Ph+ ALL.
Cancer Genet Cytogenet 185:65-67.
- de Oliveira FM, de
Figueiredo Pontes LL, Bassi SC, Dalmazzo LF, Falcão
RP (2012) Co-existence of t(6;13)(p21;q14.1) and
trisomy 12 in chronic lymphocytic leukemia. Med
Oncol 29:1227-1230.
- de Souza DC, de Figueiredo
AF, Ney Garcia DR, da Costa ES, Othman MAK, Liehr T,
Abdelhay E, Silva MLM, de Souza Fernandez T (2017) A
unique set of complex chromosomal abnormalities in
an infant with myeloid leukemia associated with Down
syndrome. Mol Cytogenet 10: 35.
- Douet-Guilbert N, Basinko
A, Eveillard JR, Morel F, Le Bris MJ, Guéganic N,
Bovo C, Herry A, Berthou C, De Braekeleer M (2010)
Three rearrangements of chromosome 5 in a patient
with myelodysplastic syndrome: an atypical deletion
5q, a complex intrachromosomal rearrangement of
chromosome 5, and a paracentric inversion of
chromosome 5. Cancer Genet Cytogenet 203:303-308.
- Elghezal H, Le Guyader G,
Radford-Weiss I, Perot C, Van Den Akker J, Eydoux P,
Vekemans M, Romana SP (2001) Reassessment of
childhood B-lineage lymphoblastic leukemia
karyotypes using spectral analysis. Genes Chr Cancer
30: 383-392
- Fan YS, Siu VM, Jung JH, Xu
J (2000) Sensitivity of multiple color spectral
karyotyping in detecting small interchromosomal
rearrangements. Genet Test 4:9-14.
- Faria De Figueiredo A,
Liehr T, Bhatt S, Binato R, Tavares De Souza M,
Rodrigues Capela De Matos R, De Jesus Marques Salles
T, Jordy FC, Ribeiro RC, Abdelhay E, Luiza Macedo
Silva M (2011) A complex karyotype masked a cryptic
variant t(8;21)(q22;q22) in a child with acute
myeloid leukemia. Leuk Lymphoma 52:1593-1596.
- Fears S, Chakrabarti SR,
Nucifora G, Rowley JD (2002) Differential expression
of TCL1 during pre-B-cell acute lymphoblastic
leukemia progression. Cancer Genet Cytogenet 135:
110-119.
- Feurstein S, Thomay K,
Hofmann W, Buesche G, Kreipe H, Thol F, Heuser M,
Ganser A, Schlegelberger B, Göhring G (2018) Routes
of clonal evolution into complex karyotypes in
myelodysplastic syndrome patients with 5q deletion.
Int J Mol Sci 19. pii: E3269.
- Fleischman EW, Reshmi S,
Sokova OI, Kirichenko OP, Konstantinova LN, Kulagina
OE, Frenkel MA, Rowley JD (1999) Increased karyotype
precision using fluorescence in situ hybridization
and spectral karyotyping in patients with myeloid
malignancies. Cancer Genet Cytogenet 108: 166-170.
- Fonzar Hernandes MA, de
Jesus Marques-Salles T, Mkrtchyan H, Soares-Ventura
EM, Pereira Leite E, Cartaxo Muniz MT, Marquim
Nogueira Cornélio MT, Liehr T, Santos N, Macedo
Silva ML. Extra copies of der(21)t(12;21) plus
deletion of ETV6 gene due to dic(12;18) in B-cell
precursor ALL with poor outcome. Case Reports Genet,
2012, doi: 10.1155/2012/186532
- Gabrea A, Martelli ML, Qi
Y, Roschke A, Barlogie B, Shaughnessy JD Jr, Sawyer
JR, Kuehl WM (2008) Secondary genomic rearrangements
involving immunoglobulin or MYC loci show similar
prevalences in hyperdiploid and nonhyperdiploid
myeloma tumors. Genes Chromosomes Cancer 47:573-590.
- Gamerdinger U,
Teigler-Schlegel A, Pils S, Bruch J, Viehmann S,
Keller M, Jauch A, Harbott J (2003) Cryptic
chromosomal aberrations leading to an AML1/ETO
rearrangement are frequently caused by small
insertions. Genes Chromosomes Cancer 36: 261-272.
- Gerr HD, Nassin ML, Davis
EM, Jayathilaka N, Neilly ME, Schlegelberger B,
Zhang Y, Rowley JD (2007) Cytogenetic and molecular
study of the PRDX4 gene in a t(X;18)(p22;q23): a
cautionary tale. Cancer Genet Cytogenet 176:131-136
- Gribble SM, Roberts I,
Grace C, Andrews KM, Green AR, Nacheva EP (2000)
Cytogenetics of the chronic myeloid leukemia-derived
cell line K562: karyotype clarification by
multicolor fluorescence in situ hybridization,
comparative genomic hybridization, and
locus-specific fluorescence in situ hybridization.
Cancer Genet Cytogenet 118: 1-8.
- Gribble SM, Reid AG, Bench
AJ, Huntly BJ, Grace C, Green AR, Nacheva EP (2003)
Molecular cytogenetics of polycythaemia vera: lack
of occult rearrangements detectable by 20q LSP
screening, CGH, and M-FISH. Leukemia 17: 1419-1421.
- Gribble SM, Reid AG,
Roberts I, Grace C, Green AR, Nacheva EP (2003)
Genomic imbalances in CML blast crisis:
8q24.12-q24.13 segment identified as a common region
of over-representation. Genes Chromosomes Cancer 37:
346-358.
- Giguère A, Hébert J (2011)
Microhomologies and topoisomerase II consensus
sequences identified near the breakpoint junctions
of the recurrent t(7;21)(p22;q22) translocation in
acute myeloid leukemia. Genes Chromosomes Cancer
50:228-238.
- Gotou M, Hanamura I,
Nagoshi H, Wakabayashi M, Sakamoto N, Tsunekawa N,
Horio T, Goto M, Mizuno S, Takahashi M, Suganuma K,
Yamamoto H, Hiramatsu A, Watarai M, Shikami M,
Imamura A, Mihara H, Taki T, Miwa H, Taniwaki M,
Nitta M (2012) Establishment of a novel human
myeloid leukemia cell line, AMU-AML1, carrying
t(12;22)(p13;q11) without chimeric MN1-TEL and with
high expression of MN1.Genes Chromosomes Cancer
51:42-53.
- Guo B, DA WM, Han XP, Sun
JF, Huang WR, Wang K (2006) [Primary application of
spectral karyotyping in leukemia] Zhonghua Yi Xue Za
Zhi 86:2978-2981. Chinese.
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XP, Sun JF, Wang LL, Huang WR, Da WM (2011)
[Application of spectral karyotyping to cytogenetic
analysis in acute myeloid leukemia]. Zhonghua Xue Ye
Xue Za Zhi 32:454-457. Chinese.
- Guo B, Han X, Wu Z, Da W,
Zhu H (2014) Spectral karyotyping: an unique
technique for the detection of complex genomic
rearrangements in leukemia. Transl Pediatr 3:
135-139.
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R, Maciejewski JP, List A (2008) Myelodysplastic
syndromes with del(5q): indications and strategies
for cytogenetic testing. Cancer Genet Cytogenet
187:101-111.
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Kovacs G, Krivan G, Tamaska J, Klein G, Fekete G,
Imreh S (2006) Jumping translocation of 17q11
approximately qter and 3q25 approximately q28
duplication in a variant Philadelphia
t(9;14;22)(q34;q32;q11) in a childhood chronic
myelogenous leukemia. Cancer Genet Cytogenet 164:
74-80.
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Sauvageau M, Fetni R, Busque L, Hebert J (2006)
Overexpression of PRDM16 in the presence and absence
of the RUNX1/PRDM16 fusion gene in myeloid
leukemias. Genes Chromosomes Cancer 45:1072-1076.
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Yang F, Butler T, Cheung KL, Kearney L, Dirscherl L,
Bray-Ward P, Gregson M, Ferguson-Smith M (2000)
Multiplex fluorescence in situ hybridization and
cross species color banding of a case of chronic
myeloid leukemia in blastic crisis with a complex
Philadelphia translocation. Cancer Genet Cytogenet
116: 105-110.
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Cheung KL, Gerrard G, Jalali GR, Mehta A, Osier DG,
Orchard KH (2003) Cytogenetics of multiple myeloma:
interpretation of fluorescence in situ hybridization
results. Br J Haematol 120:944-952
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Entz-Werle N, Falkenrodt A, Eyer D, Aurich-Costa J,
CHerif D, Lutz P, Lessard M (2002) Translocation
t(5;14) (q35;q32) in three cases of childhood T cell
acute lymphoblastic leukemia: a new recurring and
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S, Karamysheva TV, Sablina OV, Degtyareva MM, Starke
H, Metzke H, Claussen U, Liehr T (2003) Highly
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H, Loncarevic IF, Claussen U, Liehr T (2004)
Characterization of a highly aberrant plasma cell
leukemia karyotype: a case report. Oncol Rep
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Morel F, Le Bris MJ, Guéganic N, Berthou C, De
Braekeleer M (2010) Isochromosome 5p and related
anomalies: a novel recurrent chromosome abnormality
in myeloid disorders. Cancer Genet Cytogenet
200:134-139.
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T, Wakui K, Yanagisawa R, Nakazawa Y, Sakashita K,
Shiohara M, Ishii E, Koike K (2007) A complex
karyotype, including a three-way translocation
generating a NUP98-HOXD13 transcript, in an infant
with acute myeloid leukemia. Cancer Genet Cytogenet
176:137-143
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H, Schröck E, Ried T (1999) Analysis of B-cell
neoplasias by spectral karyotyping (SKY). Curr Top
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Philadelphia-positive chronic myeloid leukemia
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J, Inamura J, Hosoki T, Shindo M, Sato K, Takahashi
H, Kohgo Y (2008) A novel five-way chromosomal
translocation observed in chronic myelogenous
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S, Morimoto A, Fukushima Y, Ijuin I, Hada S,
Kitabayashi I, Abe T, Imashuku S (2003)
Rearrangement of the MOZ gene in pediatric
therapy-related myelodysplastic syndrome with a
novel chromosomal translocation t(2;8)(p23;p11).
Genes Chromosomes Cancer 36: 413-419.
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M, Aventin A, Rocchi M, Storlazzi CT (2008) Similar
mechanisms formed ring markers containing chromosome
12 pericentromeric region in two patients with
therapy-related acute myeloid leukemia. Cancer Genet
Cytogenet 181:131-137
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Taniwaki M, Yamaguchi H, Tanosaki S, Dan K (2001)
Establishment of a cell line with AML1-MTG8, TP53,
and TP73 abnormalities from acute myelogenous
leukemia. Genes Chr Cancer 32: 182-187.
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Makishima H, Suzawa K, Hosaka S, Hidaka E, Ishikawa
M, Yamauchi K, Kitano K, Kiyosawa K (2002)
t(8;21;14)(q22;q22;q24) is a novel variant of
t(8;21) with chimeric transcripts of AML1-ETO in
acute myelogenous leukemia. Cancer Genet Cytogenet
132: 133-135.
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Watanabe K, Nakamura N, Toyota S, Kobayashi H, Tohda
S (2010) Amplification of IGH/CCND1 fusion gene in a
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SI, Block AW, Barcos M, Slack JL, Wetzler M, Baer MR
(2004) Massive hyperdiploidy and tetraploidy in
acute myelocytic leukemia and myelodysplastic
syndrome. Cancer Genet Cytogenet 148: 29-34.
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Mihal V, Lakoma I, Divoky V, Blazek B, Pospisilova
D, Hajduch M, Novak Z, Dusek L, Koptikova J, Poulsen
TS, Indrak K (2003) Complex karyotypes in childhood
acute lymphoblastic leukemia: cytogenetic and
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|
Cell lines
|
see also SKY Karyotypes
and FISH analysis of Epithelial Cancer Cell Lines at
http://www.path.cam.ac.uk/~pawefish/
see also SKY/M-FISH and CGH
Database
The data in this study
were submitted to dbVar by the SKY-CGH database upon its
retirement in September, 2016. They consist of detailed
cytogenetic analyses of tumor-vs.-normal cancer samples
from a wide variety of cases. The data are currently
being curated for display in dbVar; in the meantime,
they can be downloaded by following this
FTP link.
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