ChromosOmics - Database

Icon by Leon Liehr              

   - mFISH - whole chromosome paints (wcps) -    

TUMOR CYTOGENETICS

mFISH with whole chromosome paints as probes is extensively applied in tumor cytogenetics.
For review see e.g.:
  • Bayani JM, Squire JA (2002) Applications of SKY in cancer cytogenetics. Cancer Invest 20:373-386.
  • Calasanz MJ, Cigudosa JC (2008) Molecular cytogenetics in translational oncology: when chromosomes meet genomics. Clin Transl Oncol 10:20-29
  • Nowell PC, Rowley JD, Knudson AG Jr (1998) Cancer genetics, cytogenetics--defining the enemy within. Nat Med 4: 1107-1111
(molecular) cytogenetics is necessar for tumorcytogenetic diagnostics
  • Granada I, Palomo L, Ruiz-Xivillé N, Mallo M, Solé F (2020) Cytogenetics in the genomic era. Best Pract Res Clin Haematol 33: 101196.

leukemia
lymphomas solid tumors cell lines

Leukemia

  • Abe S, Ishikawa I, Harigae H, Sugawara T (2008) A new complex translocation t(5;17;15)(q11;q21;q22) in acute promyelocytic leukemia. Cancer Genet Cytogenet 184:44-47.
  • Abdelhaleem M, Shago M, Sayeh E, Abla O (2007) Childhood myeloid/natural killer precursor acute leukemia with novel chromosomal aberrations der(5)t(4;5)(q31;q31.3) and t(14;17)(q32;q23). Cancer Genet Cytogenet 178:141-143.
  • Ahuja HG, Popplewell L, Tcheurekdjian L, Slovak ML (2001) NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia. Genes Chr Cancer 30: 410-415.
  • Al Achkar W, Wafa A, Mkrtchyan H, Moassas F, Liehr T (2010) A rare case of chronic myeloid leukemia with secondary chromosomal changes including partial trisomy 17q21 to 17qter and partial monosomy of 16p13.3. Mol Cytogenet 3:6.
  • Al Achkar W, Wafa A, Ali BY, Manvelyan M, Liehr T (2010) A rare chronic myeloid leukemia case with Philadelphia chromosome, BCR-ABL e13a3 transcript and complex translocation involving four different chromosomes. Oncol Lett 1:797-800.
  • Al Achkar W, Wafa A, Mkrtchyan H, Moassass F, Liehr T (2010) A rare case of Philadelphia chromosome-positive chronic myelogenous leukemia with inversion in chromosome 9 and t(10;17). Oncol Lett 1:793-795.
  • Andersen MK, Christiansen DH, Pedersen-Bjergaard J (2005) Centromeric breakage and highly rearranged chromosome derivatives associated with mutations of TP53 are common in therapy-related MDS and AML after therapy with alkylating agents: An M-FISH study. Genes Chr Cancer 42: 358-371.
  • Avet-Loiseau H, Daviet A, Brigaudeau C, Callet-Bauchu E, Terre C, Lafage-Pochitaloff M, Desangles F, Ramond S, Talmant P, Bataille R (2001) Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myelome and the Groupe Francais de Cytogenetique Hematologique. Blood 97: 822-825.
  • Babicka L, Zemanova Z, Pavlistova L, Brezinova J, Ransdorfova S, Houskova L, Moravcova J, Klamova H, Michalova K (2006) Complex chromosomal rearrangements in patients with chronic myeloid leukemia. Cancer Genet Cytogenet 168:22-29.
  • Bacher U, Haferlach T, Schoch C (2005) Gain of 9p due to an unbalanced rearrangement der(9;18): a recurrent clonal abnormality in chronic myeloproliferative disorders. Cancer Genet Cytogenet 160: 179-183
  • Bacher U, Haferlach T, Kern W, Harich HD, Schnittger S, Haferlach C (2007) A case of chronic myeloproliferative syndrome followed by precursor T-cell acute lymphoblastic leukemia. Cancer Genet Cytogenet 175:52-56.
  • Bacher U, Haferlach C (2008) FISH in the diagnosis of hematological neoplasias. Medgen 20: 367-373. (German)
  • Bai S, Xue Y, Wu Y, Pan J, Zhang J, Shen J, Wang Y, Qiu H (2008) [Simultaneous presence of ins (15;17),t(2;17;20) and trisomy 8 in a patient with acute promyelocytic leukemia.] Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:712-714. Chinese.
  • Bakshi SR, Patel BP, Brahmbhatt MM, Trivedi PJ, Gajjar SB, Iyer RR, Parikh EH, Shukla SN, Shah PM (2009) Complex karyotype with a masked Philadelphia translocation and variant BCR-ABL fusion in CML. Cancer Genet Cytogenet 189:142-143.
  • Barber KE, Ford AM, Harris RL, Harrison CJ, Moorman AV (2004) MLL translocations with concurrent 3' deletions: interpretation of FISH results. Genes Chromosomes Cancer 41:266-271.
  • Barbouti A, Johansson B, Hoglund M, Mauritzson N, Strombeck B, Nilsson PG, Tanke HJ, Hagemeijer A, Mitelman F, Fioretos T (2002) Multicolor COBRA-FISH analysis of chronic myeloid leukemia reveals novel cryptic balanced translocations during disease progression. Genes Chromosomes Cancer 35: 127-137.
  • Barouk-Simonet E, Soenen-Cornu V, Roumier C, Cosson A, Lai JL, Fenaux P, Preudhomme C (2005) Role of multiplex FISH in identifying chromosome involvement in myelodysplastic syndromes and acute myeloid leukemias with complex karyotypes: a report on 28 cases. Cancer Genet Cytogenet 157:118-126.
  • Batista DA, Vonderheid EC, Hawkins A, Morsberger L, Long P, Murphy KM, Griffin CA (2006) Multicolor fluorescence in situ hybridization (SKY) in mycosis fungoides and Sezary syndrome: search for recurrent chromosome abnormalities. Genes Chromosomes Cancer 45: 383-391.
  • Betts DR, Niggli FK, Cohen N, Rechavi G, Amariglio N, Trakhtenbrot L (2008) SKY reveals a high frequency of unbalanced translocations involving chromosome 6 in t(12;21)-positive acute lymphoblastic leukemia. Leuk Res 32:39-43.
  • Bezrookove V, van Zelderen-Bhola SL, Brink A, Szuhai K, Raap AK, Barge R, Beverstook CG, Rosenberg C (2004) A novel t(6;14)(q25~q27;q32) in acute myelocytic leukemia involves the BCL11B gene. Cancer Genet Cytogenet 149: 72-76.
  • Brezinova J, Zemanova Z, Ransdorfova S, Sindelarova L, Siskova M, Neuwirtova R, Cermak J, Michalova K (2005) Prognostic significance of del(20q) in patients with hematological malignancies. Cancer Genet Cytogenet 160: 188-192
  • Brizard F, Cividin M, Villalva C, Guilhot F, Brizard A (2004) Comparison of M-FISH and conventional cytogenetic analysis in accelerated and acute phases of CML. Leuk Res 28:345-348
  • Calabrese G, Fantasia D, Franch PG, Morizio E, Stuppia L, Gatta V, Olioso P, Mingarelli R, Spadano A, Palka G (2000) Spectral karyotyping (SKY) refinement of a complex karyotype with t(20;21) in a Ph-positive CML patient submitted to peripheral blood stem cell transplantation. Bone Marrow Transplant 26: 1125-1127.
  • Calabrese G, Fantasia D, Morizio E, Toro PM, Franchi PG, Fornaro A, Spadano A, Stuppia L, Palka G (2003) Chromosome 11 rearrangements and specific MLL amplification revealed by spectral karyotyping in a patient with refractory anaemia with excess of blasts (RAEB).Br J Haematol 122:760-763
  • Capela de Matos RR, Ney Garcia DR, Cifoni E, Othman MAK, Tavares de Souza M, Carboni EK, Ferreira GM, Liehr T, Ribeiro RC, M Silva (2017) MLGAS6 oncogene and reverse MLLT3-KMT2A duplications in an infant with acute myeloid leukemia and a novel complex hyperdiploid karyotype: detailed high-resolution molecular cytogenetic studies. Cytogenet Genome Res 152: 33-37.
  • Chae H, Kim M, Lim J, Kim Y, Han K, Lee S (2010) B lymphoblastic leukemia with ETV6 amplification. Cancer Genet Cytogenet 203:284-287.
  • Chen BA, Xia GH, Li JY, Xiao B, Shao ZY, Chen NN, Gao C, Wu YJ (2006) Detection of complex karyotype in a myelodysplastic syndrome cell line (MUTZ-1) by metaphase fluorescence in situ hybridization. Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:46-49
  • Chen S, Xue Y, Zhang X, Wu Y, Pan J, Wang Y, Ceng J (2005) A new human acute monocytic leukemia cell line SHI-1 with t(6;11)(q27;q23), p53 gene alterations and high tumorigenicity in nude mice. Haematologica 90:766-775
  • Chen LJ, Li JY, Xiao B, Zhu Y, Liu Q, Pan JL, Qiu HR, Fan L, Zhang SJ, Lu RN, Xu W, Xue YQ (2007) [Analysis of complex chromosomal aberrations in patients with myelodysplastic syndromes using multiplex fluorescence in situ hybridization combined with whole chromosome painting] Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:635-639. Chinese.
  • Cigudosa JC, Odero MD, Calasanz MJ, Sole F, Salido M, Arranz E, Martinez-Ramirez A, Urioste M, Alvarez S, Cervera JV, MacGrogan D, Sanz MA, Nimer SD, Benitez J (2003) De novo erythroleukemia chromosome features include multiple rearrangements, with special involvement of chromosomes 11 and 19. Genes Chromosomes Cancer 36: 406-412.
  • Cohen N, Trakhtenbrot L, Yukla M, Mandor Y, Gaber E, Yosef G, Amariglio N, Rechavi G, Amiel A (2002) SKY detection of chromosome rearrangements in two cases of tMDS with a complex karyotype. Cancer Genet Cytogenet 138: 128-132.
  • Collado R, Hueso J, Cabello AI, Oliver I, Egea M, Orero M, Miguel-Sosa A, Cigudosa JC, Benitez J, Barragan E, Carbonell F (2006) New translocations in a case of atypical B-cell chronic lymphocytic leukemia: involvement of ATM, MLL, and TP53 genes. Cancer Genet Cytogenet 169:176-178.
  • Corral Mdel P, Villa O, Alfaro EM, Alonso CN, Baro C, Felice MS, Rossi J, Solé F, Gallego MS (2008) Complex chromosome 8;21 translocation with associated hyperdiploidy in acute myeloid leukemia (FAB-M2). Pediatr Blood Cancer 50:651-654
  • Cox MC, Panetta P, Lo-Coco F, Del Poeta G, Venditti A, Maurillo L, Del Principe MI, Mauriello A, Anemona L, Bruno A, Mazzone C, Palombo P, Amadori S (2004) Chromosomal aberration of the 11q23 locus in acute leukemia and frequency of MLL gene translocation: results in 378 adult patients. Am J Clin Pathol 122:298-306
  • Crescenzi B, La Starza R, Nozzoli C, Ciolli S, Matteucci C, Romoli S, Rigacci L, Gorello P, Bosi A, Martelli MF, Marynen P, Mecucci C (2007) Molecular cytogenetic findings in a four-way t(1;12;5;12)(p36;p13;q33;q24) underlying the ETV6-PDGFRB fusion gene in chronic myelomonocytic leukemia. Cancer Genet Cytogenet 176:67-71.
  • Dai H, Xue Y, Pan J, Wu Y, Wang Y, Shen J, Zhang J (2007) Two novel translocations disrupt the RUNX1 gene in acute myeloid leukemia. Cancer Genet Cytogenet 177:120-124
  • Dalley CD, Neat MJ, Foot NJ, Burridge M, Byrne L, Amess JA, Rohatiner AZ, Lister A, Young BD, Lillington DM (2002) Comparative genomic hybridization and multiplex-fluorescence in situ hybridization: an appraisal in elderly patients with acute myelogenous leukemia. Hematol J 3:290-298
  • Davidsson J, Paulsson K, Johansson B (2005 Multicolor fluorescence in situ hybridization characterization of cytogenetically polyclonal hematologic malignancies. Cancer Genet Cytogenet 163:180-183.
  • de Jesus Marques-Salles T, Mkrtchyan H, Pereira Leite E, Soares-Ventura EM, Cartaxo-Muniz MT, Ferreira E, Liehr T, Macedo Silva ML, Santos N (2010) Complex karyotype defined by FISH and M-FISH studies in an infant with acute megakarioblastic leukemia and neurofibromatosis. Cancer Genet Cytogenet 200: 167-169.
  • de Oliveira FM, Tone LG, Simoes BP, Falcao RP, Brassesco MS, Sakamoto-Hojo ET, dos Santos GA, Marinato AF, Jacomo RH, Rego EM (2007) Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of cyclin D1. Cancer Genet Cytogenet 172:154-157.
  • de Oliveira FM, Tone LG, Simões BP, Rego EM, Marinato AF, Jácomo RH, Falcão RP (2009) Translocations t(X;14)(q28;q11) and t(Y;14)(q12;q11) in T-cell prolymphocytic leukemia. Int J Lab Hematol 31:453-456.
  • de Oliveira FM, Falcão RP, de Figueiredo Pontes LL, Simões BP, Tone LG (2008) Insertion (15;14)(q22;q13q32) in a case of Ph+ ALL. Cancer Genet Cytogenet 185:65-67.
  • de Oliveira FM, de Figueiredo Pontes LL, Bassi SC, Dalmazzo LF, Falcão RP (2012) Co-existence of t(6;13)(p21;q14.1) and trisomy 12 in chronic lymphocytic leukemia. Med Oncol 29:1227-1230.
  • de Souza DC, de Figueiredo AF, Ney Garcia DR, da Costa ES, Othman MAK, Liehr T, Abdelhay E, Silva MLM, de Souza Fernandez T (2017) A unique set of complex chromosomal abnormalities in an infant with myeloid leukemia associated with Down syndrome. Mol Cytogenet 10: 35.
  • Douet-Guilbert N, Basinko A, Eveillard JR, Morel F, Le Bris MJ, Guéganic N, Bovo C, Herry A, Berthou C, De Braekeleer M (2010) Three rearrangements of chromosome 5 in a patient with myelodysplastic syndrome: an atypical deletion 5q, a complex intrachromosomal rearrangement of chromosome 5, and a paracentric inversion of chromosome 5. Cancer Genet Cytogenet 203:303-308.
  • Elghezal H, Le Guyader G, Radford-Weiss I, Perot C, Van Den Akker J, Eydoux P, Vekemans M, Romana SP (2001) Reassessment of childhood B-lineage lymphoblastic leukemia karyotypes using spectral analysis. Genes Chr Cancer 30: 383-392
  • Fan YS, Siu VM, Jung JH, Xu J (2000) Sensitivity of multiple color spectral karyotyping in detecting small interchromosomal rearrangements. Genet Test 4:9-14.
  • Faria De Figueiredo A, Liehr T, Bhatt S, Binato R, Tavares De Souza M, Rodrigues Capela De Matos R, De Jesus Marques Salles T, Jordy FC, Ribeiro RC, Abdelhay E, Luiza Macedo Silva M (2011) A complex karyotype masked a cryptic variant t(8;21)(q22;q22) in a child with acute myeloid leukemia. Leuk Lymphoma 52:1593-1596.
  • Fears S, Chakrabarti SR, Nucifora G, Rowley JD (2002) Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression. Cancer Genet Cytogenet 135: 110-119.
  • Feurstein S, Thomay K, Hofmann W, Buesche G, Kreipe H, Thol F, Heuser M, Ganser A, Schlegelberger B, Göhring G (2018) Routes of clonal evolution into complex karyotypes in myelodysplastic syndrome patients with 5q deletion. Int J Mol Sci 19. pii: E3269.
  • Fleischman EW, Reshmi S, Sokova OI, Kirichenko OP, Konstantinova LN, Kulagina OE, Frenkel MA, Rowley JD (1999) Increased karyotype precision using fluorescence in situ hybridization and spectral karyotyping in patients with myeloid malignancies. Cancer Genet Cytogenet 108: 166-170.
  • Fonzar Hernandes MA, de Jesus Marques-Salles T, Mkrtchyan H, Soares-Ventura EM, Pereira Leite E, Cartaxo Muniz MT, Marquim Nogueira Cornélio MT, Liehr T, Santos N, Macedo Silva ML. Extra copies of der(21)t(12;21) plus deletion of ETV6 gene due to dic(12;18) in B-cell precursor ALL with poor outcome. Case Reports Genet, 2012, doi: 10.1155/2012/186532
  • Gabrea A, Martelli ML, Qi Y, Roschke A, Barlogie B, Shaughnessy JD Jr, Sawyer JR, Kuehl WM (2008) Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors. Genes Chromosomes Cancer 47:573-590.
  • Gamerdinger U, Teigler-Schlegel A, Pils S, Bruch J, Viehmann S, Keller M, Jauch A, Harbott J (2003) Cryptic chromosomal aberrations leading to an AML1/ETO rearrangement are frequently caused by small insertions. Genes Chromosomes Cancer 36: 261-272.
  • Gerr HD, Nassin ML, Davis EM, Jayathilaka N, Neilly ME, Schlegelberger B, Zhang Y, Rowley JD (2007) Cytogenetic and molecular study of the PRDX4 gene in a t(X;18)(p22;q23): a cautionary tale. Cancer Genet Cytogenet 176:131-136
  • Gribble SM, Roberts I, Grace C, Andrews KM, Green AR, Nacheva EP (2000) Cytogenetics of the chronic myeloid leukemia-derived cell line K562: karyotype clarification by multicolor fluorescence in situ hybridization, comparative genomic hybridization, and locus-specific fluorescence in situ hybridization. Cancer Genet Cytogenet 118: 1-8.
  • Gribble SM, Reid AG, Bench AJ, Huntly BJ, Grace C, Green AR, Nacheva EP (2003) Molecular cytogenetics of polycythaemia vera: lack of occult rearrangements detectable by 20q LSP screening, CGH, and M-FISH. Leukemia 17: 1419-1421.
  • Gribble SM, Reid AG, Roberts I, Grace C, Green AR, Nacheva EP (2003) Genomic imbalances in CML blast crisis: 8q24.12-q24.13 segment identified as a common region of over-representation. Genes Chromosomes Cancer 37: 346-358.
  • Giguère A, Hébert J (2011) Microhomologies and topoisomerase II consensus sequences identified near the breakpoint junctions of the recurrent t(7;21)(p22;q22) translocation in acute myeloid leukemia. Genes Chromosomes Cancer 50:228-238.
  • Gotou M, Hanamura I, Nagoshi H, Wakabayashi M, Sakamoto N, Tsunekawa N, Horio T, Goto M, Mizuno S, Takahashi M, Suganuma K, Yamamoto H, Hiramatsu A, Watarai M, Shikami M, Imamura A, Mihara H, Taki T, Miwa H, Taniwaki M, Nitta M (2012) Establishment of a novel human myeloid leukemia cell line, AMU-AML1, carrying t(12;22)(p13;q11) without chimeric MN1-TEL and with high expression of MN1.Genes Chromosomes Cancer 51:42-53.
  • Guo B, DA WM, Han XP, Sun JF, Huang WR, Wang K (2006) [Primary application of spectral karyotyping in leukemia] Zhonghua Yi Xue Za Zhi 86:2978-2981. Chinese.
  • Guo B, Zhu HL, Li SX, Han XP, Sun JF, Wang LL, Huang WR, Da WM (2011) [Application of spectral karyotyping to cytogenetic analysis in acute myeloid leukemia]. Zhonghua Xue Ye Xue Za Zhi 32:454-457. Chinese.
  • Guo B, Han X, Wu Z, Da W, Zhu H (2014) Spectral karyotyping: an unique technique for the detection of complex genomic rearrangements in leukemia. Transl Pediatr 3: 135-139.
  • Haferlach C, Bacher U, Tiu R, Maciejewski JP, List A (2008) Myelodysplastic syndromes with del(5q): indications and strategies for cytogenetic testing. Cancer Genet Cytogenet 187:101-111.
  • Haltrich I, Kost-Alimova M, Kovacs G, Krivan G, Tamaska J, Klein G, Fekete G, Imreh S (2006) Jumping translocation of 17q11 approximately qter and 3q25 approximately q28 duplication in a variant Philadelphia t(9;14;22)(q34;q32;q11) in a childhood chronic myelogenous leukemia. Cancer Genet Cytogenet 164: 74-80.
  • Hazourli S, Chagnon P, Sauvageau M, Fetni R, Busque L, Hebert J (2006) Overexpression of PRDM16 in the presence and absence of the RUNX1/PRDM16 fusion gene in myeloid leukemias. Genes Chromosomes Cancer 45:1072-1076.
  • Harrison CJ, Gibbons B, Yang F, Butler T, Cheung KL, Kearney L, Dirscherl L, Bray-Ward P, Gregson M, Ferguson-Smith M (2000) Multiplex fluorescence in situ hybridization and cross species color banding of a case of chronic myeloid leukemia in blastic crisis with a complex Philadelphia translocation. Cancer Genet Cytogenet 116: 105-110.
  • Harrison CJ, Mazzullo H, Cheung KL, Gerrard G, Jalali GR, Mehta A, Osier DG, Orchard KH (2003) Cytogenetics of multiple myeloma: interpretation of fluorescence in situ hybridization results. Br J Haematol 120:944-952
  • Hélias C, Leymarie V, Entz-Werle N, Falkenrodt A, Eyer D, Aurich-Costa J, CHerif D, Lutz P, Lessard M (2002) Translocation t(5;14) (q35;q32) in three cases of childhood T cell acute lymphoblastic leukemia: a new recurring and cryptic abnormality. Leukemia 16: 7-12.
  • Heller A, Rubtsov N, Kytölä S, Karamysheva TV, Sablina OV, Degtyareva MM, Starke H, Metzke H, Claussen U, Liehr T (2003) Highly complex karyotypic changes in acute myelogenous leukemia: a case report. Int J Oncol 23:139-143
  • Heller A, Fricke HJ, Starke H, Loncarevic IF, Claussen U, Liehr T (2004) Characterization of a highly aberrant plasma cell leukemia karyotype: a case report. Oncol Rep 11:89-92
  • Herry A, Douet-Guilbert N, Morel F, Le Bris MJ, Guéganic N, Berthou C, De Braekeleer M (2010) Isochromosome 5p and related anomalies: a novel recurrent chromosome abnormality in myeloid disorders. Cancer Genet Cytogenet 200:134-139.
  • Hess JL (1998) Detection of chromosome translocations in leukemia: is there a best way? Am J Clin Pathol 109: 3-5.
  • Hidaka E, Tanaka M, Matsuda K, Ishikawa-Matsumura M, Yamauchi K, Sano K, Honda T, Wakui K, Yanagisawa R, Nakazawa Y, Sakashita K, Shiohara M, Ishii E, Koike K (2007) A complex karyotype, including a three-way translocation generating a NUP98-HOXD13 transcript, in an infant with acute myeloid leukemia. Cancer Genet Cytogenet 176:137-143
  • Hilgenfeld E, Padilla-Nash H, Schröck E, Ried T (1999) Analysis of B-cell neoplasias by spectral karyotyping (SKY). Curr Top Microbiol Immunol 246: 169-174.
  • Holzerová M, Faber E, Veselovská J, Urbánková H, Balcárková J, Rozmanová S, Voglová J, Muzík J, Chroust K, Indrák K, Jarosová M; CAMELIA-Chronic Myeloid Leukaemia Project (2009) Imatinib mesylate efficacy in 72 previously treated Philadelphia-positive chronic myeloid leukemia patients with and without additional chromosomal changes: single-center results. Cancer Genet Cytogenet 191:1-9.
  • Ikuta K, Torimoto Y, Jimbo J, Inamura J, Hosoki T, Shindo M, Sato K, Takahashi H, Kohgo Y (2008) A novel five-way chromosomal translocation observed in chronic myelogenous leukemia. Cancer Genet Cytogenet 183:69-71.
  • Imamura T, Kakazu N, Hibi S, Morimoto A, Fukushima Y, Ijuin I, Hada S, Kitabayashi I, Abe T, Imashuku S (2003) Rearrangement of the MOZ gene in pediatric therapy-related myelodysplastic syndrome with a novel chromosomal translocation t(2;8)(p23;p11). Genes Chromosomes Cancer 36: 413-419.
  • Impera L, Albano F, Mancini M, Aventin A, Rocchi M, Storlazzi CT (2008) Similar mechanisms formed ring markers containing chromosome 12 pericentromeric region in two patients with therapy-related acute myeloid leukemia. Cancer Genet Cytogenet 181:131-137
  • Inokuchi K, Hamaguchi H, Taniwaki M, Yamaguchi H, Tanosaki S, Dan K (2001) Establishment of a cell line with AML1-MTG8, TP53, and TP73 abnormalities from acute myelogenous leukemia. Genes Chr Cancer 32: 182-187.
  • Ishida F, Ueno M, Tanaka H, Makishima H, Suzawa K, Hosaka S, Hidaka E, Ishikawa M, Yamauchi K, Kitano K, Kiyosawa K (2002) t(8;21;14)(q22;q22;q24) is a novel variant of t(8;21) with chimeric transcripts of AML1-ETO in acute myelogenous leukemia. Cancer Genet Cytogenet 132: 133-135.
  • Ishigaki T, Sasaki K, Watanabe K, Nakamura N, Toyota S, Kobayashi H, Tohda S (2010) Amplification of IGH/CCND1 fusion gene in a primary plasma cell leukemia case. Cancer Genet Cytogenet 201:62-65.
  • Iyer RV, Sait SN, Matsui SI, Block AW, Barcos M, Slack JL, Wetzler M, Baer MR (2004) Massive hyperdiploidy and tetraploidy in acute myelocytic leukemia and myelodysplastic syndrome. Cancer Genet Cytogenet 148: 29-34.
  • Jaffray JY, Giollant M, Perissel B, Vago P (2002) [From "monocolor" karyotype to "multicolor" karyotype: applications of M-Fish in hematology and oncology] Bull Cancer 89: 174-80. French.
  • Jarosova M, Holzerova M, Mihal V, Lakoma I, Divoky V, Blazek B, Pospisilova D, Hajduch M, Novak Z, Dusek L, Koptikova J, Poulsen TS, Indrak K (2003) Complex karyotypes in childhood acute lymphoblastic leukemia: cytogenetic and molecular cytogenetic study of 21 cases. Cancer Genet Cytogenet 145: 161-168.
  • Jiang JD, Davis AS, Middleton K, Ling YH, Perez-Soler R, Holland JF, Bekesi JG (1998) 3-(Iodoacetamido)-benzoylurea: a novel cancericidal tubulin ligand that inhibits microtubule polymerization, phosphorylates bcl-2, and induces apoptosis in tumor cells. Cancer Res 58: 5389-5395.
  • Jiang YQ, Chen LJ, Zhu Y, Qiu HR, Wang R, Xu JR, Lu H, Li JY (2010) [Detection of complex chromosomal aberrations in patients with multiple myeloma using multiplex fluorescence in situ hybridization]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:441-444. Chinese.
  • Johansson B, Axelsson P, Billstrom R, Strombeck B, Arheden K, Olofsson T, Cervin A, Adriansson M, Tanke H, Mitelman F, Fioretos T (2001) Isodicentric 7p, idic(7)(q11.2), in acute myeloid leukemia associated with older age and favorable response to induction chemotherapy: A new clinical entity? Genes Chr Cancer 30: 261-266.
  • Jurkowska M, Zekanowski C, Malinowska I, Zielenska M (2001) [Molecular diagnosis of lymphomas and leukaemias].Med Wieku Rozwoj V(2): 113-134. Polish.
  • Kakazu N, Taniwaki M, Horiike S, Nishida K, Tatekawa T, Nagai M, Takahashi T, Akaogi T, Inazawa J, Ohki M, Abe T (1999) Combined spectral karyotyping and DAPI banding analysis of chromosome abnormalities in myelodysplastic syndrome. Genes Chr Cancer 26: 336-345.
  • Karhu R, Vilpo L, Isola J, Knuutila S, Vilpo J (2002) Cryopreserved chronic lymphocytic leukemia cells analyzed by multicolor fluorescence in situ hybridization after optimized mitogen stimulation. Genes Chromosomes Cancer 34: 345-348.
  • Kawata E, Kuroda J, Kimura S, Kamitsuji Y, Kobayashi Y, Yoshikawa T (2002) Aplastic anemia evolving into overt myelodysplastic syndrome/acute myeloid leukemia with t(3;5)(p25;q31). Cancer Genet Cytogenet 137:91-94.
  • Kearney L, Horsley SW (2005) Molecular cytogenetics in haematological malignancy: current technology and future prospects. Chromosoma 114:286-294
  • Kearney L (2006) Multiplex-FISH (M-FISH): technique, developments and applications. Cytogenet Genome Res 114:189-198.
  • Kearney L, Colman S (2009) Specialized Fluorescence In Situ Hybridization (FISH) Techniques for Leukaemia Research. Methods Mol Biol 538:1-14.
  • Kerndrup GB, Kjeldsen E (2001) Acute leukemia cytogenetics: an evaluation of combining G-band karyotyping with multi-color spectral karyotyping. Cancer Genet Cytogenet 124: 7-11.
  • Khac FN, Waill M-C, Romana SP, Radford-Weiss I, Busson M, Collogne-Rame M-A, Ribadeau-Dumas A, Piffaut M-C, Daniel M-T, Davi F, Merle-Beral H, Berger R, Arock M (2002) Identical abnormality of the short arm of chromosome 18 in two Philadelphia-positive chronic myelocytic leukemia patients with erythroblastic transformation, resulting in duplication of BCR-ABL1 fusion. Cancer Genet Cytogenet 138: 22-26.
  • Kjeldsen E (2017) Characterization of an acquired jumping translocation involving 3q13.31-qter in a patient with de novo acute monocytic leukemia. Exp Mol Pathol 103:14-25.
  • Kjeldsen E (2018) A novel acquired t(2;4)(q36.1;q24) with a concurrent submicroscopic del(4)(q23q24) in an adult with polycythemia vera. Cancers (Basel) 10: E214.
  • Knutsen T, Pack S, Petropavlovskaja M, Padilla-Nash H, Knight C, Mickley LA, Ried T, Elwood PC, Roberts SJ (2003) Cytogenetic, spectral karyotyping, fluorescence in situ hybridization, and comparative genomic hybridization characterization of two new secondary leukemia cell lines with 5q deletions, and MYC and MLL amplification. Genes Chromosomes Cancer 37: 270-281.
  • Knutsen T, Vakulchuk A, Mosijczuk AD, Gabrea A, Ried T, Tretyak N (2006) Complex rearrangements involving der(8)t(8;20) and der(14)t(8;14)t(11;14), CCND1, and duplication of IgH constant region in acute plasmablastic leukemia. Cancer Genet Cytogenet 164:137-141.
  • Kobayashi K, Usami I, Kubota M, Nishio T, Kakazu N (2005) Chromosome 7 abnormalities in acute megakaryoblastic leukemia associated with Down syndrome. Cancer Genet Cytogenet 158:184-187.
  • Kolialexi A, Tsangaris GT, Kitsiou S, Kanavakis E, Mavrou A (2005) Impact of cytogenetic and molecular cytogenetic studies on hematologic malignancies. Anticancer Res 25:2979-2983
  • Krstic AD, Impera L, Guc-Scekic M, Lakic N, Djokic D, Slavkovic B, Storlazzi CT (2009) A complex rearrangement involving cryptic deletion of ETV6 and CDKN1B genes in a case of childhood acute lymphoblastic leukemia. Cancer Genet Cytogenet 195:125-131.
  • Kubota Y, Waki M (2010) Chronic myeloid leukemia with a novel four-way t(6;13;9;22)(p21;q32;q34;q11.2) successfully treated with imatinib mesylate. Cancer Genet Cytogenet 201:135-136.
  • La Starza R, Crescenzi B, Pierini V, Romoli S, Gorello P, Brandimarte L, Matteucci C, Kropp MG, Barba G, Martelli MF, Mecucci C (2007) A common 93-kb duplicated DNA sequence at 1q21.2 in acute lymphoblastic leukemia and Burkitt lymphoma. Cancer Genet Cytogenet 175:73-76.
  • Lange K, Holm L, Vang Nielsen K, Hahn A, Hofmann W, Kreipe H, Schlegelberger B, Göhring G (2010) Telomere shortening and chromosomal instability in myelodysplastic syndromes. Genes Chromosomes Cancer 49:260-269.
  • Lee S, Kim M, Lim J, Kim Y, Han K, Kim HJ, Cho SG, Min WS (2009) Acute myeloid leukemia with MYC amplification in the homogeneous staining regions and double minutes. Cancer Genet Cytogenet 192:96-98.
  • Leung E, Teshima I, Ye C, Grant R, Abdelhaleem M (2005) A der(19)t(12;19)(q12;p13.3) in a case of pediatric acute leukemia with unusual immunophenotype. Cancer Genet Cytogenet 157:164-168.
  • Li JY, Ma L, Xiao B, Pan JL, Qiu HR, Wu YF, Wen BZ, Xue YQ (2006) [Detection of the complex chromosomal aberrations in acute lymphoblastic leukemia by means of multiplex fluorescence in situ hybridization] Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:42-45. Chinese
  • Li JY, Xiao B, Chen LJ, Pan JL, Xu W, Qiu HR, Li L, Xue YQ (2008) An analysis of complex chromosomal aberrations in seven cases of myelodysplastic syndromes by M-FISH and whole chromosome painting. Int J Hematol 88:369-373.
  • Liu YC, Sashida G, Kodama A, Ohyashiki K (2006) Translocation (4;9)(q11;q33), a new rearrangement in acute myeloid leukemia with central nervous system involvement. Cancer Genet Cytogenet 165: 85-86.
  • Liu YC, Miyazawa K, Sashida G, Kodama A, Ohyashiki K (2006) Deletion (20q) as the sole abnormality in Waldenstrom macroglobulinemia suggests distinct pathogenesis of 20q11 anomaly. Cancer Genet Cytogenet 169:69-72.
  • Liu SY, Huang JW, Zhang J, Du HP, Jiang H, Li JY, Xue YQ (2007) [Fluorescence in situ hybridization identifies complex chromosomal aberrations in multiple myeloma] Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:685-688. ChineseLu XY, Harris CP, Cooley L, Margolin J, Steuber PC, Sheldon M, Rao PH, Lau CC (2002) The utility of spectral karyotyping in the cytogenetic analysis of newly diagnosed pediatric acute lymphoblastic leukemia. Leukemia 16: 2222-2227.
  • Macedo Silva ML, Land M, Heller A, Abdelhay E, do Socorro Pombo-de-Oliveira M, Ribeiro R, Alves G, Lerner D, Liehr T (2005) New rearrangement t(3;17)(q26.3;q12) in an AML patient with a poor outcome. Oncol Rep 14: 663-666.
  • Macedo Silva ML, Raimondi SC, Abdelhay E, Gross M, Mkrtchyan H, de Figueiredo AF, Ribeiro RC, de Jesus Marques-Salles T, Sobral ES, Gerardin Land MP, Liehr T (2008) Banding and molecular cytogenetic studies detected a CBFB-MYH11 fusion gene that appeared as abnormal chromosomes 1 and 16 in a baby with acute myeloid leukemia FAB M4-Eo. Cancer Genet Cytogenet 182:56-60.
  • MacKinnon RN, Zordan A, Campbell LJ (2005) Recurrent duplication of Xq27-qter in hematological malignancies revealed by multicolor fluorescence in situ hybridization and multicolor banding. Cancer Genet Cytogenet 161:125-129.
  • Mackinnon RN, Campbell LJ (2013) Chromothripsis under the microscope: a cytogenetic perspective of two cases of AML with catastrophic chromosome rearrangement. Cancer Genet 206: 238-251.
  • Manor E, Bellaiche E, Bodner L (2006) Cytogenetic findings of a primary Merkel cell carcinoma. Cancer Genet Cytogenet 169:78-80.
  • Manor E, Bodner L, Kachko P, Kapelushnik J (2010) Derivative (22)t(3;22)(q12;p11.1) in desmoplastic medulloblastoma. Cancer Genet Cytogenet 196:175-178.
  • Mark HF, Gray Y, Mark Y, Khorsand J, Sikov W (1999) A multimodal approach in the diagnosis of patients with hematopoietic disorders. Cancer Genet Cytogenet 109: 14-20.
  • Markovic VD, Bouman D, Bayani J, Al-Maghrabi J, Kamel-Reid S, Squire J (2000) Lack of BCR/ABL reciprocal fusion in variant Philadelphia chromosome translocations: a use of double fusion signal FISH and spectral karyotyping. Leukemia 14: 1157-1160.
  • Marques-Salles T de J, Mkrtchyan H, Leite EP, Soares-Ventura EM, Muniz MT, Silva EF, Liehr T, Silva ML, Santos N (2010) Complex karyotype defined by molecular cytogenetic FISH and M-FISH in an infant with acute megakaryoblastic leukemia and neurofibromatosis. Cancer Genet Cytogenet 200:167-169.
  • Martineau M, Jalali GR, Barber KE, Broadfield ZJ, Cheung KL, Lilleyman J, Moorman AV, Richards S, Robinson HM, Ross F, Harrison CJ (2005) ETV6/RUNX1 fusion at diagnosis and relapse: some prognostic indications. Genes Chromosomes Cancer 43:54-71.
  • Martinez-Ramirez A, Urioste M, Alvarez S, Vizmanos JL, Calasanz MJ, Cigudosa JC, Benitez J (2004) Cytogenetic profile of myelodysplastic syndromes with complex karyotypes: an analysis using spectral karyotyping. Cancer Genet Cytogenet 153(1):39-47.
  • Mathew S, Rao PH, Dalton J, Downing JR, Raimondi SC (2001) Multicolor spectral karyotyping identifies novel translocations in childhood acute lymphoblastic leukemia. Leukemia 15: 468-472.
  • Matsuda K, Hidaka E, Ishida F, Yamauchi K, Makishima H, Ito T, Suzuki T, Imagawa E, Sano K, Katsuyama T, Ota H (2006) A case of acute myelogenous leukemia with MLL-AF10 fusion caused by insertion of 5'MLL into 10p12, with concurrent 3'MLL deletion. Cancer Genet Cytogenet 171:24-30.
  • Matsuda K, Tanaka M, Araki S, Yanagisawa R, Yamauchi K, Koike K (2009) Cryptic insertion into 11q23 of MLLT10 not involved in t(1;15;11;10)(p36;q11;q23;q24) in infant acute biphenotypic leukemia. Cancer Genet Cytogenet 190:113-120.
  • Melichercikova J, Brezinova J, Zemanova Z, Cermak J, Michalova K (2007) Molecular cytogenetic analysis of complex karyotypes with derivative chromosome der(1)t(1;5) found in two patients with myeloid leukemia. Cancer Genet Cytogenet 176:150-155
  • Michalova K, Zemanova Z, Brezinova J (2001) [Multicolor fluorescence in situ hybridization (mFISH]. Cas Lek Cesk 140: 99-103. Czech.
  • Michalova K, Zemanova Z, Brezinova J (2002) Analysis of structural chromosomal aberrations by mFISH and mBAND techniques. In: Early prenatal diagnosis, fetal cells and DNA in the mother - present state and perpectives. The Karolinum Press, Prag, pp 284-292, ISBN: 80-246-0397-7.
  • Miyagi J, Kakazu N, Masuda M, Miyagi T, Toyohama T, Nakazato T, Tomoyose T, Shinjyo T, Nagasaki A, Taira N, Ohki M, Abe T, Takasu N (2002) Acute myeloid leukemia (FAB-M2) with a masked type of t(8;21) translocation revealed by spectral karyotyping. Int J Hematol 76:338-343.
  • Miyazaki K, Kikukawa M, Kiuchi A, Shin K, Iwamoto T, Ohyashiki K (2007) Complex translocations derived stepwise from standard t(15;17) in a patient with variant acute promyelocytic leukemia. Cancer Genet Cytogenet 176:127-130
  • Mkrtchyan H, Glaser M, Gross M, Wedding U, Hoffken K, Liehr T, Karst C, Aroutiounian R (2006) Multicolor-FISH applied to resolve complex chromosomal changes in a case of T-ALL (FAB L2). Cytogenet Genome Res 114:270-273.
  • Mkrtchyan H, Garcia Ney DR, de Ventura ES, Liehr T, Felix GR, de Jesus Marques-Salles T, Abdelhay E, Macedo Silva ML (2010) Molecular cytogenetic studies characterize a near-triploid complex karyotype in a child with acute lymphoblastic leukemia. Cancer Genet Cytogenet 197:71-74.
  • Mocker K, Holland H, Ahnert P, Schober R, Bauer M, Kirsten H, Koschny R, Meixensberger J, Krupp W (2011) Multiple meningioma with different grades of malignancy: case report with genetic analysis applying single-nucleotide polymorphism array and classical cytogenetics. Pathol Res Pract 207:67-72.
  • Mohr B, Bornhauser M, Thiede C, Schakel U, Schaich M, Illmer T, Pascheberg U, Ehninger G (2000) Comparison of spectral karyotyping and conventional cytogenetics in 39 patients with acute myeloid leukemia and myelodysplastic syndrome. Leukemia 14: 1031-1038.
  • Mohr B, Bornhauser M, Platzbecker U, Freiberg-Richter J, Naumann R, Prange-Krex G, Mohm J, Kroschinsky F, Ehninger G, Thiede C (2001) Problems with interphase fluorescence in situ hybridization in detecting BCR/ABL-positive cells in some patients using a novel technique with extra signals.Cancer Genet Cytogenet 127:111-117.
  • Monma F, Nishii K, Yamamori S, Hosokai N, Nakazaki T, Lorenzo F 5th, Usui E, Sakakura M, Miyashita H, Fujieda A, Ohishi K, Katayama N, Shiku H (2004) Fluorescent in situ hybridization analysis of Philadelphia chromosome-negative chronic myeloid leukemia with the bcr/abl fusion gene. Int J Hematol 80:155-158
  • Morel F, Herry A, Le Bris MJ, Morice P, Bouquard P, Abgrall JF, Berthou C, De Braekeleer M (2003) Contribution of fluorescence in situ hybridization analyses to the characterization of masked and complex Philadelphia chromosome translocations in chronic myelocytic leukemia. Cancer Genet Cytogenet 147: 115-120.
  • Mrózek K (2008) Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype. Semin Oncol 35:365-377.
  • Mrozek K, Heinonen K, Theil KS, Bloomfield CD (2002) Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q.Genes Chromosomes Cancer, 34: 137-153.
  • Mrozek K, Tanner SM, Heinonen K, Bloomfield CD (2003) Molecular cytogenetic characterization of the KG-1 and KG-1a acute myeloid leukemia cell lines by use of spectral karyotyping and fluorescence in situ hybridization. Genes Chromosomes Cancer 38: 249-252.
  • Nacheva EP, Gribble S, Andrews K, Wienberg J, Grace CD (2000) Screening for specific chromosome involvement in hematological malignancies using a set of seven chromosome painting probes. An alternative approach for chromosome analysis using standard FISH instrumentation. Cancer Genet Cytogenet 122: 65-72.
  • Ning Y, Liang JC, Nagarajan L, Schröck E, Ried T (1998) Characterization of 5q deletions by subtelomeric probes and spectral karyotyping. Cancer Genet Cytogenet 103: 170-172.
  • Nordgren A (2003) Hidden aberrations diagnosed by interphase fluorescence in situ hybridisation and spectral karyotyping in childhood acute lymphoblastic leukaemia. Leuk Lymphoma 44:2039-2053
  • Nordgren A, Heyman M, Sahlen S, Schoumans J, Soderhall S, Nordenskjold M, Blennow E (2002) Spectral karyotyping and interphase FISH reveal abnormalities not detected by conventional G-banding. Implications for treatment stratification of childhood acute lymphoblastic leukaemia: detailed analysis of 70 cases. Eur J Haematol 68: 31-41.
  • Odero MD, Carlson K, Calasanz MJ, Lahortiga I, Chinwalla V, Rowley JD (2001) Identification of new translocations involving ETV6 in hematologic malignancies by fluorescence in situ hybridization and spectral karyotyping. Genes Chr Cancer 31: 134-142.
  • Odero MD, Carlson KM, Calasanz MJ, Rowley JD (2001) Further characterization of complex chromosomal rearrangements in myeloid malignancies: spectral karyotyping adds precision in defining abnormalities associated with poor prognosis. Leukemia 15: 1133-1136.
  • Odero MD, Vizmanos JL, Roman JP, Lahortiga I, Panizo C, Calasanz MJ, Zeleznik-Le NJ, Rowley JD, Novo FJ (2002) A novel gene, MDS2, is fused to ETV6/TEL in a t(1;12)(p36.1;p13) in a patient with myelodysplastic syndrome. Genes Chromosomes Cancer 35: 11-19.
  • Odero MD, Carlson K, Lahortiga I, Calasanz MJ, Rowley JD (2003) Molecular cytogenetic characterization of breakpoints in 19 patients with hematologic malignancies and 12p unbalanced translocations. Cancer Genet Cytogenet 142:115-119.
  • Ohsaka A, Hisa T, Watanabe N, Kojima H, Nagasawa T (2002) Tetrasomy 21 as a sole chromosome abnormality in acute myeloid leukemia. fluorescence in situ hybridization and spectral karyotyping analyses. Cancer Genet Cytogenet 134: 60-64.
  • Ohsaka A, Hisa T (2002) Spectral karyotyping refined the identification of a der(Y)t(Y;1)(q11.1 or.2;q12) in the blast cells of a patient with atypical chronic myeloid leukemia. Acta Haematol 107: 224-229.
  • Ohsaka A, Otsubo K, Yokota H, Hisa T, Saito H, Kozaki T (2008) Spectral karyotyping and fluorescence in situ hybridization analyses identified a novel three-way translocation involving inversion 16 in therapy-related acute myeloid leukemia M4eo. Cancer Genet Cytogenet 184:113-118.
  • Ohyashiki K, Kodama A, Ohyashiki JH (2008) Recurrent der(9;18) in essential thrombocythemia with JAK2 V617F is highly linked to myelofibrosis development. Cancer Genet Cytogenet; 186:6-11.
  • Othman MAK, Melo JB, Carreira IM, Rincic M, Alhourani E, Wilhelm K, Gruhn B, Glaser A, Liehr T (2015) MLLT10 and IL3 rearrangement together with a complex four-way-translocation and trisomy 4 in a patient with early T-cell precursor acute lymphoblastic leukemia. Oncol Rep 33: 625-630.
  • Othman MAK, Melo JB, Carreira IM, Rincic M, Glaser A, Grygalewicz B, Gruhn B, Wilhelm K, Rittscher K, Meyer B, Silva MLM, de Jesus Marques Salles T, Liehr T (2015) High rates of submicroscopic aberrations in karyotypically normal acute lymphoblastic leukemia. Mol Cytogenet 8: 45.
  • Panagopoulos I, Isaksson M, Lindvall C, Bjorkholm M, Ahlgren T, Fioretos T, Heim S, Mitelman F, Johansson B (2000) RT-PCR analysis of the MOZ-CBP and CBP-MOZ chimeric transcripts in acute myeloid leukemias with t(8;16)(p11;p13). Genes Chromosomes Cancer 28: 415-424.
  • Park TS, Song J, Lee KA, Kim J, Kim SJ, Lee JH, Choi JR, Cheong JW, Park R, Hwang SH, Lee EY (2008) Complex t(8;19;21)(q22;p13;q22) as a sole abnormality in a patient with de novo acute myeloid leukemia. Cancer Genet Cytogenet 185:109-112
  • Park TS, Lee ST, Song J, Lee KA, Lee SG, Kim J, Suh B, Kim SJ, Lee JH, Park R, Choi JR (2008) MLL rearrangement with t(6;11)(q15;q23) as a sole abnormality in a patient with de novo acute myeloid leukemia: conventional cytogenetics, FISH, and multicolor FISH analyses for detection of rare MLL-related chromosome abnormalities. Cancer Genet Cytogenet 187:50-53.
  • Park TS, Kim J, Song J, Song S, Suh B, Choi JR, Kim SJ, Lee HW, Min YH (2009) Association between acute promyelocytic leukemia and ring chromosome 6. Cancer Genet Cytogenet 192:48-50.
  • Park TS, Choi JR, Yoon SH, Song J, Kim J, Kim SJ, Kwon O, Min YH (2008) Acute promyelocytic leukemia relapsing as secondary acute myelogenous leukemia with translocation t(3;21)(q26;q22) and RUNX1-MDS1-EVI1 fusion transcript. Cancer Genet Cytogenet 187:61-73.
  • Paulsson K, Fioretos T, Strömbeck B, Mauritzson N, Tanke HJ, Johansson B (2003) Trisomy 8 as a sole chromosomal aberration in mylocytic malignancies: a multicolor and locus-specific fluorescence in situ hybridization study. Cancer Genet Cytogenet 140: 66-69.
  • Paulsson K, Morse H, Fioretos T, Behrendtz M, Strombeck B, Johansson B (2005) Evidence for a single-step mechanism in the origin of hyperdiploid childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer 44:113-122.
  • Pavlistova L, Izakova S, Zemanova Z, Bartuskova L, Langova M, Malikova P, Michalova K (2016)  Rare congenital chromosomal aberration dic(X;Y)(p22.33;p11.32) in a patient with primary myelofibrosis. Mol Cytogenet 9: 67.
  • Poppe B, Cauwelier B, Van Limbergen H, Yigit N, Philippé J, Verhasselt B, De Paepe A, Benoit Y, Speleman F (2005) Novel cryptic chromosomal rearrangements in childhood acute lymphoblastic leukemia detected by multiple color fluorescent in situ hybridization. Haematologica 90:1179-1185
  • Poppe B, De Paepe A, Speleman F (2007) Acquired chromosomal rearrangements targeting selected transcription factors: contribution of molecular cytogenetic and expression analyses to the identification of clinically and biologically relevant subgroups in hematological malignancies. Verh K Acad Geneeskd Belg 69:47-64
  • Preiss BS, Kerndrup GB, Pedersen RK, Hasle H, Pallisgaard N; Lymphoma-Leukemia Study Group of the Region of Southern Denmark (2006) Contribution of multiparameter genetic analysis to the detection of genetic alterations in hematologic neoplasia. An evaluation of combining G-band analysis, spectral karyotyping, and multiplex reverse-transcription polymerase chain reaction (multiplex RT-PCR). Cancer Genet Cytogenet 165:1-8.
  • Qiu HR, Li JY, Zhu Y, Hong M, Wang R, Xu W (2007) [A case of acute promyelocytic leukemia with double ider (17q-)] Zhongguo Shi Yan Xue Ye Xue Za Zhi 15:1309-1311. Chinese
  • Qiu HR, Li JY, Miao KR, Wang R, Xu W (2008) Clinical and laboratory studies of an acute promyelocytic leukemia patient with double ider(17q) chromosome aberration. Cancer Genet Cytogenet 184:74-75
  • Qiu H, Xue Y, Zhang J, Pan J, Dai H, Wu Y, Wang Y, Chen S, Wu D (2008) Establishment and characterization of a new human acute myelocytic leukemia cell line SH-2 with a loss of Y chromosome, a derivative chromosome 16 resulting from an unbalanced translocation between chromosomes 16 and 17, monosomy 17, trisomy 19, and p53 alteration. Exp Hematol 36:1487-1495.
  • Qiu HR, Li JY, Miao KR, Wang R, Zhang JF, Xu W (2008) [A case of acute promyelocytic leukemia with variant t(5;17) and trisomy 22] Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:430-433. Chinese.
  • Olnes MJ, Poon A, Miranda SJ, Pfannes L, Tucker Z, Loeliger K, Padilla-Nash H, Yau YY, Ried T, Leitman SF, Young NS, Sloand EM (2012) Effects of granulocyte-colony-stimulating factor on Monosomy 7 aneuploidy in healthy hematopoietic stem cell and granulocyte donors. Transfusion 52:537-541.
  • Rao PH, Cigudosa JC, Ning Y, Calasanz MJ, Iida S, Tagawa S, Michaeli J, Klein B, Dalla-Favera R, Jhanwar SC, Ried T, Chaganti RS (1998) Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma. Blood 92: 1743-1748.
  • Rayeroux KC, Campbell LJ (2009) Gene amplification in myeloid leukemias elucidated by fluorescence in situ hybridization. Cancer Genet Cytogenet 193:44-53.
  • Roschke AV, Tonon G, Gehlhaus KS, McTyre N, Bussey KJ, Lababidi S, Scudiero DA, Weinstein JN, Kirsch IR (2003) Karyotypic complexity of the NCI-60 drug-screening panel. Cancer Res 63:8634-8647.
  • Rowley JD, Reshmi S, Carlson K, Roulston D (1999) Spectral karyotype analysis of T-cell acute leukemia. Blood 93:2038-2042.
  • Rowley JD (2000) Molecular genetics in acute leukemia. Leukemia 14: 513-517.
  • Rowley JD (2001) Chromosome translocations: dangerous liaisons revisited. Nat Rev Cancer 1: 245-250.
  • Saez B, Martin-Subero JI, Largo C, Martin MC, Odero MD, Prosper F, Siebert R, Calasanz MJ, Cigudosa JC (2006) Identification of recurrent chromosomal breakpoints in multiple myeloma with complex karyotypes by combined G-banding, spectral karyotyping, and fluorescence in situ hybridization analyses. Cancer Genet Cytogenet 169:143-149.
  • Sait SN, Qadir MU, Conroy JM, Matsui S, Nowak NJ, Baer MR (2002) Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndrome: identification of new amplification regions by fluorescence in situ hybridization and spectral karyotyping. Genes Chr Cancer 34: 42-47.
  • Saito H, Otsubo K, Kakimoto A, Komatsu N, Ohsaka A (2010) Emergence of two unrelated clones in acute myeloid leukemia with MLL-SEPT9 fusion transcript. Cancer Genet Cytogenet 201:111-115
  • Salamanchuk Z, Jakóbczyk M, Nowak W, Skotnicki AB (2004) Complex cytogenetics in a case of probably work related MDS/AML. Leuk Res 28:1357-1361
  • Sakai I, Tamura T, Narumi H, Uchida N, Yakushijin Y, Hato T, Fujita S, Yasukawa M (2005) Novel RUNX1-PRDM16 fusion transcripts in a patient with acute myeloid leukemia showing t(1;21)(p36;q22). Genes Chromosomes Cancer 44:265-270.
  • Sandberg AA, Meloni-Ehrig AM (2010) Cytogenetics and genetics of human cancer: methods and accomplishments. Cancer Genet Cytogenet 203:102-126.
  • Sárová I, Brezinová J, Zemanová Z, Lizcová L, Berková A, Izáková S, Malinová E, Fuchs O, Kostecka A, Provazníková D, Filkuková J, Maaloufová J, Starý J, Michalová K (2009) A partial nontandem duplication of the MLL gene in four patients with acute myeloid leukemia. Cancer Genet Cytogenet 2009; 195:150-156.
  • Sárová I, Brezinová J, Zemanová Z, Izáková S, Lizcová L, Malinová E, Berková A, Cermák J, Maaloufová J, Nováková L, Michalová K (2010) Cytogenetic manifestation of chromosome 11 duplication/amplification in acute myeloid leukemia. Cancer Genet Cytogenet 199:121-127.
  • Sarova I, Brezinova J, Zemanova Z, Bystricka D, Krejcik Z, Soukup P, Vydra J, Cermak J, Jonasova A, Michalova K (2013) Characterization of chromosome 11 breakpoints and the areas of deletion and amplification in patients with newly diagnosed acute myeloid leukemia. Genes Chromosomes Cancer 52:619-635.
  • Sarova I, Brezinova J, Zemanova Z, Ransdorfova S, Izakova S, Svobodova K, Pavlistova L, Berkova A, Cermak J, Jonasova A, Siskova M, Michalova K (2016) Molecular cytogenetic analysis of dicentric chromosomes in acute myeloid leukemia. Leuk Res 43: 51-57.
  • Sarova I, Brezinova J, Zemanova Z, Ransdorfova S, Svobodova K, Izakova S, Pavlistova L, Lizcova L, Berkova A, Skipalova K, Hodanova L, Salek C, Jonasova A, Michalova K (2018) High frequency of dicentric chromosomes detected by multi-centromeric FISH in patients with acute myeloid leukemia and complex karyotype. Leuk Res 68:85-89.
  • Sawyer JR, Lukacs JL, Munshi N, Desikan KR, Singhal S, Mehta J, Siegel D, Shaughnessy J, Barlogie B (1998) Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping. Blood 92: 4269-4278.
  • Schoch C, Haferlach T, Bursch S, Gerstner D, Schnittger S, Dugas M, Kern W, Loffler H, Hiddemann W (2002) Loss of genetic material is more common than gain in acute myeloid leukemia with complex aberrant karyotype: A detailed analysis of 125 cases using conventional chromosome analysis and fluorescence in situ hybridization including 24-color FISH. Genes Chromosomes Cancer 35: 20-29.
  • Scholz I, Popp S, Granzow M, Schoell B, Holtgreve-Grez H, Takeuchi S, Schrappe M, Harbott J, Teigler-Schlegel A, Zimmermann M, Fischer C, Koeffler HP, Bartram CR, Jauch A (2001) Comparative genomic hybridization in childhood acute lymphoblastic leukemia: correlation with interphase cytogenetics and loss of heterozygosity analysis. Cancer Genet Cytogenet 124:89-97.
  • Serakinci N, Ostergaard M, Larsen H, Madsen B, Pedersen B, Koch J (2002) Multiple telomeric aberrations in a telomerase-positive leukemia patient. Cancer Genet Cytogenet 138: 11-16.
  • Shali W, Helias C, Fohrer C, Struski S, Gervais C, Falkenrodt A, Leymarie V, Lioure B, Raby P, Herbrecht R, Lessard M (2006) Cytogenetic studies of a series of 43 consecutive secondary myelodysplastic syndromes/acute myeloid leukemias: conventional cytogenetics, FISH, and multiplex FISH. Cancer Genet Cytogenet 168:133-145.
  • Shiba N, Tamura K, Kanazawa T, Tsukada S, Koitabashi M, Morikawa A (2007) Novel three-way t(4;5;22)(q35;q31;q13) in acute megakaryoblastic leukemia. Cancer Genet Cytogenet 174:82-83.
  • Shimada H, Shimizu K, Mimaki S, Sakiyama T, Mori T, Shimasaki N, Yokota J, Nakachi K, Ohta T, Ohki M (2004) First case of aplastic anemia in a Japanese child with a homozygous missense mutation in the NBS1 gene (I171V) associated with genomic instability. Hum Genet 115: 372-376.
  • Shimoyama M, Yamamoto K, Nishikawa S, Minagawa K, Katayama Y, Matsui T (2009) Duplication of isodicentric chromosome 21, idic(21)(p11.2), leading to pentasomy 21q in acute myeloid leukemia with multilineage dysplasia. Cancer Genet Cytogenet 194:38-43.
  • Shou Y, Martelli ML, Gabrea A, Qi Y, Brents LA, Roschke A, Dewald G, Kirsch IR, Bergsagel PL, Kuehl WM (2000) Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma. Proc Natl Acad Sci U S A 97: 228-233.
  • Slater DJ, Hilgenfeld E, Rappaport EF, Shah N, Meek RG, Williams WR, Lovett BD, Osheroff N, Autar RS, Ried T, Felix CA (2002) MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site. Oncogene 21: 4706-4714.
  • Smith A, Das P, O'Reilly J, Patsouris C, Campbell LJ (2006) Three adults with acute lymphoblastic leukemia and dic(7;9)(p11.2;p11). Cancer Genet Cytogenet 166: 86-88.
  • Stark B, Jeison M, Gobuzov R, Finkelshtein S, Ash S, Avrahami G, Cohen IJ, Stein J, Yaniv I, Zaizov R, Bar-Am I (2000) Apparently unrelated clones shown by spectral karyotyping to represent clonal evolution of cryptic t(10;11)(p13;q23) in a patient with acute monoblastic leukemia. Cancer Genet Cytogenet 120: 105-110.
  • Stark B, Jeison M, Gobuzov R, Krug H, Glaser-Gabay L, Luria D, El-Hasid R, Harush MB, Avrahami G, Fisher S, Stein J, Zaizov R, Yaniv I (2001) Near haploid childhood acute lymphoblastic leukemia masked by hyperdiploid line: detection by fluorescence in situ hybridization. Cancer Genet Cytogenet. 128: 108-113.
  • Stanchescu R, Betts DR, Yekutieli D, Ambros P, Cohen N, Rechavi G, Amariglio N, Trakhtenbrot L (2007) SKY analysis of childhood neural tumors and cell lines demonstrates a susceptibility of aberrant chromosomes to further rearrangements. Cancer Lett 250:47-52.
  • Stanchescu R, Betts DR, Rechavi G, Amariglio N, Trakhtenbrot L (2009) Involvement of der(12)t(12;21)(p13;q22) and as well as additional rearrangements of chromosome 12 homolog in ETV6/RUNX1-positive acute lymphoblastic leukemia. Cancer Genet Cytogenet 190:26-33.
  • Stejskalová E, Jarosová M, Malis J, Sumerauer D, Urbánková H, Krsková L, Pýcha K, Schovanec J, Balcárková J, Smelhaus V, Kodetová D, Starý J (2009) [Clinical relevance of chromosomal aberrations in bone and soft tissue tumors in children and young adults]. Klin Onkol 22:58-66. Czech.
  • Storlazzi CT, Albano F, Dencic-Fekete M, Djordjevic V, Rocchi M (2007) Late-appearing pseudocentric fission event during chronic myeloid leukemia progression. Cancer Genet Cytogenet 174:61-67.
  • Struski S, Hélias C, Gervais C, Leymarie V, Audhuy B, Moskovtchenko P, Lutz P, Gaub MP, Lessard M (2007) Confirmation of a novel recurrent association: BCR-ABL t(9;22) and t(19;21). Cancer Genet Cytogenet 179:127-131.
  • Suh B, Park TS, Kim JS, Song J, Kim J, Yoo JH, Choi JR (2009) Chronic myelomonocytic leukemia with der(9)t(1;9)(q11;q34) as a sole abnormality. Ann Clin Lab Sci 39:307-312.
  • Takeshita A, Naito K, Shinjo K, Sahara N, Matsui H, Ohnishi K, Beppu H, Ohtsubo K, Horii T, Maekawa M, Inaba T, Ohno R (2004) Deletion 6p23 and add(11)(p15) leading to NUP98 translocation in a case of therapy-related atypical chronic myelocytic leukemia transforming to acute myelocytic leukemia. Cancer Genet Cytogenet 152:56-60.
  • Takeuchi M, Katayama Y, Okamura A, Yamamoto K, Shimoyama M, Matsui T (2007) Chronic myeloid leukemia with a rare variant BCR-ABL translocation: t(9;22;21)(q34;q11.2;q11.2). Cancer Genet Cytogenet 179:85-87.
  • Takahashi T, Watanabe M, Minato M, Yoshimoto M, Tsujisaki M (2007) A novel t(12;15)(q22;q13) in a patient with acute monoblastic leukemia. Cancer Genet Cytogenet 177:164-165.
  • Tassano E, Tavella E, Micalizzi C, Scuderi F, Cuoco C, Morerio C (2011) Monosomal complex karyotype in pediatric mixed phenotype acute leukemia. Cancer Genet 204:507-511.
  • Tchinda J, Volpert S, Neumann T, Kennerknecht I, Ritter J, Buchner T, Berdel WE, Horst J (2002) Novel der(1)t(1;19) in two patients with myeloid neoplasias. Cancer Genet Cytogenet, 133: 61-65.
  • Tchinda J, Volpert S, McNeil N, Neumann T, Kennerknecht I, Ried T, Buchner T, Serve H, Berdel WE, Horst J, Hilgenfeld E (2003) Multicolor karyotyping in acute myeloid leukemia. Leuk Lymphoma 44:1843-1853.
  • Tchinda J, Neumann TE, Volpert S, Berdel WE, Buchner T, Horst J (2004) Characterization of chromosomal rearrangements in hematological diseases using spectral karyotyping. Diagn Mol Pathol 13:190-195.
  • Tchinda J, Volpert S, Berdel WE, Buchner T, Horst J (2006) Novel three-break rearrangement and cryptic translocations leading to colocalization of MYC and IGH signals in B-cell acute lymphoblastic leukemia. Cancer Genet Cytogenet 165:180-184.
  • Tirado CA, Golembiewski-Ruiz V, Horvatinovich J, Moore JO, Buckley PJ, Stenzel TT, Goodman BK (2003) Cytogenetic and molecular analysis of an unusual case of acute promyelocytic leukemia with a t(15;17;17)(q22;q23;q21). Cancer Genet Cytogenet 145: 31-37.
  • Tohda S, Nara N (2001) [Molecular diagnostic tests in hematologic diseases]. Rinsho Byori 49: 205-209. Japanese.
  • Trost D, Hildebrandt B, Beier M, Muller N, Germing U, Royer-Pokora B (2006) Molecular cytogenetic profiling of complex karyotypes in primary myelodysplastic syndromes and acute myeloid leukemia. Cancer Genet Cytogenet 165: 51-63.
  • Tsang KS, Li CK, Lau TT, Wong AP, Leung Y, Ng MH (2004) Translocation (11;13)(q23;q14) as the sole abnormality in a childhood de novo acute myelocytic leukemia. Cancer Genet Cytogenet 150: 78-80.
  • Urioste M, Martinez-Ramirez A, Cigudosa JC, Mateo MS, Martinez P, Contra T, Benitez J (2002) Identification of ins(8;21) with AML1/ETO fusion in acute myelogenous leukemia M2 by molecular cytogenetics. Cancer Genet Cytogenet 133: 83-86.
  • Van Limbergen H, Poppe B, Michaux L, Herens C, Brown J, Noens L, Berneman Z, De Bock R, De Paepe A, Speleman F (2002) Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH.Genes Chromosomes Cancer 33: 60-72.
  • Veldman T, Vignon C, Schröck E, Rowley JD, Ried T (1997) Hidden chromosome abnormalities in haematological malignancies detected by multicolour spectral karyotyping. Nat Genet 15: 406-410.
  • Vendrame-Goloni BC, Varella-Garcia M, Borduchi Carvalho-Salles A, Ruiz MA, Ricci jun O, Fett-Conte AC (2003) Translocation (11;19)(q23;p13.3) associated with a novel t(5;16)(q13;q22) in a patient with acute myelogic leukemia. Cancer Genet Cytogenet 141: 71-74.
  • Wafa A, Assad M, Liehr T, Aljapawe A, Al Achkar W (2016) A new complex karyotype in a unique de novo myelodysplastic syndrome case involving ten chromosomes and monoallelic loss of TP53. Gene Rep 4: 208-212.
  • Wafa A, Moassass F, Liehr  T, Bhatt S, Aljapawe A, Al Achkar W (2016) A high complex karyotype involving eleven chromosomes including three novel chromosomal aberrations and monoallelic loss of TP53 in case of follicular lymphoma transformed into B-cell lymphoblastic leukemia. Mol Cytogenet 9: 91.
  • Wan TS, Ma SK, Yip SF, Yeung YM, Chan LC (2000) Molecular characterization of der(15)t(11;15) as a secondary cytogenetic abnormality in acute promyelocytic leukemia with cryptic PML-RAR alpha fusion on 17q. Cancer Genet Cytogenet 121: 90-93.
  • Wan TSK, Ma SK, YIP SF, Yeung YM, Chan LC (2002) Two balanced and novel chromosomal translocations in myeloid malignancies: characterization by multiplex fluorescence in situ hybridization. Cancer Genet Cytogenet 139: 52-56
  • Wang Y, Fang M, Jing Y, Li J, Jiang F, Wang Y (2009) Derivative (7)t(7;8): The sole karyotype abnormality in acute promyelocytic leukemia with PML/RARA rearrangement identified by RT-PCR and sequence analysis. Leuk Res 33:e55-58.
  • Watanabe A, Koike K, Fukushima T, Izumi I, Ohba K, Tsuchida M (2001) [Complex translocation (8;15;21) (q22;p12;q22) in a child with AML-M2 showing de novo appearance of the short form of AML1-MTG8 chimeric mRNA during the course]. Rinsho Ketsueki 42: 110-114. Japanese.
  • Wick U, Kirsch M, Rauch A, Chudoba I, Lausen B, Efferth T, Gebhart E (2005) FISH studies on the telomeric regions of the T-cell acute lymphoblastic leukemia cell line CCRF-CEM. Cytogenet Genome Res 111: 34-40.
  • Wong N, Wong KF, Chan JK, Johnson PJ (2000) Chromosomal translocations are common in natural killer-cell lymphoma/leukemia as shown by spectral karyotyping. Hum Pathol 31: 771-774.
  • Wu W, Li JY, Zhu Y, Qiu HR, Pan JL, Xu W, Chen LJ, Shen YF, Xue YQ (2007) [Molecular genetics in chronic myeloid leukemia with variant Ph translocation] Zhonghua Yi Xue Yi Chuan Xue Za Zhi 24:470-473. Chinese
  • Xiao B, Li JY, Pan JL, Ma L, Qiu HR, Wu YF, Xue YQ (2005) [Multiplex fluorescence in situ hybridization in detecting complex chromosomal aberrations in myelodysplastic syndromes] Zhonghua Xue Ye Xue Za Zhi 26:513-516. Chinese
  • Xu W, Li JY, Liu Q, Zhu Y, Pan JL, Qiu HR, Xue YQ (2010) Multiplex fluorescence in situ hybridization in identifying chromosome involvement of complex karyotypes in de novo myelodysplastic syndromes and acute myeloid leukemia. Int J Lab Hematol 32:e86-95.
  • Yamamoto K, Nagata K, Morita Y, Inagaki K, Hamaguchi H (2002) New complex t(2;11;17)(p21;q23;q11), a variant form of t(2;11), associated with del(5)(q23q32) in myelodysplastic syndrome-derived acute myeloblastic leukemia. Cancer Genet Cytogenet 13: 119-123.
  • Yamamoto K, Hato A, Minagawa K, Yakushijin K, Urahama N, Gomyo H, Sada A, Okamura A, Ito M, Matsui T (2004) Unbalanced translocation der(11)t(11;12)(q23;q13): a new recurrent cytogenetic aberration in myelodysplastic syndrome with a complex karyotype. Cancer Genet Cytogenet 155: 67-73.
  • Yamamoto K, Ito M, Minagawa K, Urahama N, Sada A, Okamura A, Matsui T (2005) A der(13)t(7;13)(p13;q14) with monoallelic loss of RB1 and D13S319 in myelodysplastic syndrome. Cancer Genet Cytogenet 162: 160-165.
  • Yamamoto K, Yakushijin K, Kawamori Y, Minagawa K, Katayama Y, Matsui T (2007) Translocation (7;9)(q22;q34) in therapy-related myelodysplastic syndrome after allogeneic bone marrow transplantation for acute myeloblastic leukemia. Cancer Genet Cytogenet 176:61-66.
  • Yamamoto K, Okamura A, Kawano H, Katayama Y, Shimoyama M, Matsui T (2007) A novel t(8;18)(q13;q21) in acute monocytic leukemia evolving from constitutional trisomy 8 mosaicism. Cancer Genet Cytogenet 176:144-149.
  • Yamamoto K, Yakushijin K, Nishikawa S, Minagawa K, Katayama Y, Shimoyama M, Matsui T (2008) Imatinib resistance in a novel translocation der(17)t(1;17)(q25;p13) with loss of TP53 but without BCR/ABL kinase domain mutation in chronic myelogenous leukemia. Cancer Genet Cytogenet 183:77-81
  • Yamamoto K, Wakahashi K, Okamura A, Katayama Y, Shimoyama M, Matsui T (2010) Two further cases of myelodysplastic syndrome and acute myeloid leukemia with der(5;19)(p10;q10): Association with abnormalities involving chromosomes 12 and 21. Leuk Res 34:e38-41.
  • Yamamoto K, Okamura A, Wakahashi K, Katayama Y, Shimoyama M, Matsui T (2010) A novel unbalanced whole-arm translocation der(3;10)(q10;q10) in acute monocytic leukemia. Cancer Genet Cytogenet 199:134-138.
  • Yamamoto K, Sada A, Kawano Y, Katayama Y, Shimoyama M, Matsui T (2010) Therapy-related, mixed phenotype acute leukemia with t(1;21)(p36;q22) and RUNX1 rearrangement. Cancer Genet Cytogenet 201:122-127.
  • Yonescu R, Hristov AC, Ahmad A, Overby A, Thomas GH, Griffin CA (2008) Cytogenetic characterization of natural killer cell leukemia. Cancer Genet Cytogenet 183:125-130.
  • Yu F, Li CW, Wei H, Liu XP, Lin D, Gong JY, Qin S, Xu FY, Mi YC, Wang JX (2010) [Identification of complex chromosomal aberrations in acute leukemia by using conventional cytogenetics combined with multiplex fluorescence in situ hybridization.] Zhonghua Xue Ye Xue Za Zhi 31:289-293. Chinese.
  • Zagaria A, Anelli L, Albano F, Vicari L, Schiavone EM, Annunziata M, Pane F, Liso V, Rocchi M, Specchia G (2006) Molecular cytogenetic characterization of deletions on der(9) in chronic myelocytic leukemia. Cancer Genet Cytogenet 167: 97-102
  • Zemanova Z, Michalova K, Sindelarova L, Smisek P, Brezinova J, Ransdorfova S, Vavra V, Dohnalova A, Stary J (2005) Prognostic value of structural chromosomal rearrangements and small cell clones with high hyperdiploidy in children with acute lymphoblastic leukemia. Leuk Res. 29:273-281
  • Zhang FF, Murata-Collins JL, Gaytan P, Forman SJ, Kopecky KJ, Willman CL, Appelbaum FR, Slovak ML (2000) Twenty-four-color spectral karyotyping reveals chromosome aberrations in cytogenetically normal acute myeloid leukemia. Genes Chromosomes Cancer 28: 318-328.
  • Zhao L, Hayes K, Khan Z, Glassman A (2001) Spectral karyotyping study of chromosome abnormalities in human leukemia.Cancer Genet Cytogenet 127:143-147, + Erratum, Cancer Genet Cytogenet 131: 94-95.
  • Zhao M, Chen B, Wang L, Xu L, Cao Q, Su X, Chen S (2002) [Establishment and application of multiplex FISH in detection of the complex chromosome abnormalities in leukemia] Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:375-378. Chinese
  • Zhou HF, Li JY, Pan JL, Qiu HR, Chen LJ, Hu JY, Shen YF, Xu W, Xue YQ (2007) [Study of trisomy 22 and inversion 16 in acute myeloid leukemia] Zhonghua Xue Ye Xue Za Zhi 28:11-14. Chinese
  • Zhu Y, Li JY, Xu W, Qiu HR, Chen LJ, Pan JL, Shen YF, Xue YQ (2007) [Multiplex fluorescence in situ hybridization for detecting complex chromosomal aberrations in chronic myeloid leukemia in blast crisis] Zhonghua Xue Ye Xue Za Zhi 28:458-461. Chinese
  • Zhu Y, Xu W, Liu Q, Pan J, Qiu H, Wang R, Qiao C, Jiang Y, Zhang S, Fan L, Zhang J, Shen Y, Xue Y, Li J (2008) [Abnormalities of chromosome 17 in myeloid malignancies with complex chromosomal abnormalities] Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:579-582. Chinese.
  • Zuna J, Burjanivova T, Mejstrikova E, Zemanova Z, Muzikova K, Meyer C, Horsley SW, Kearney L, Colman S, Ptoszkova H, Marschalek R, Hrusak O, Stary J, Greaves M, Trka J (2009) Covert preleukemia driven by MLL gene fusion. Genes Chromosomes Cancer 48:98-107.
  • Zuna J, Zaliova M, Muzikova K, Meyer C, Lizcova L, Zemanova Z, Brezinova J, Votava F, Marschalek R, Stary J, Trka J (2010) Acute leukemias with ETV6/ABL1 (TEL/ABL) fusion: poor prognosis and prenatal origin. Genes Chromosomes Cancer 49:873-884.
  • Zhou GN, Chen BA (2010) [M-FISH technique in diagnosis and prognostic analysis for acute leukemia with complex chromosomal aberrations]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:246-249. Review. Chinese.
Lymphoma


  • Aamot H, Micci F, Holte H, Delabie J, Heim S (2002) M-FISH cytogenetic analysis of non-Hodgkin lymphomas with t(14;18)(q32;q21) and add(1)(p36) as a secondary abnormality shows that the extra material often comes from chromosome arm 17q. Leuk Lymphoma 43: 1051-1056.
  • Aamot HV, Micci F, Holte H, Delabie J, Heim S (2005) G-banding and molecular cytogenetic analyses of marginal zone lymphoma. Br J Haematol 130:890-901
  • Aamot HV, Bjørnslett M, Delabie J, Heim S (2005) t(14;22)(q32;q11) in non-Hodgkin lymphoma and myeloid leukaemia: molecular cytogenetic investigations. Br J Haematol 130:845-851.
  • Aamot HV, Tjonnfjord GE, Delabie J, Heim S (2006) Molecular cytogenetic analysis of leukemic mantle cell lymphoma with a cryptic t(11;14).Cancer Genet Cytogenet165:172-175.
  • Alvares CL, Matutes E, Scully MA, Swansbury J, Min T, Gruszka-Westwood AM, Atkinson S, Hilditch B, Morilla R, Wotherspoon AC, Catovsky D (2004) Isolated bone marrow involvement in diffuse large B cell lymphoma: a report of three cases with review of morphological, immunophenotypic and cytogenetic findings. Leuk Lymphoma 45:769-775
  • Bacher U, Haferlach T, Schnittger S, Weiss T, Burkhard O, Bechtel B, Kern W, Haferlach C (2010) Detection of a t(4;14)(p16;q32) in two cases of lymphoma showing both the immunophenotype of chronic lymphocytic leukemia. Cancer Genet Cytogenet 200:170-174.
  • Balcárková J, Urbánková H, Scudla V, Holzerová M, Bacovský J, Indrák K, Jarosová M (2009) Gain of chromosome arm 1q in patients in relapse and progression of multiple myeloma. Cancer Genet Cytogenet 192:68-72.
  • Baró C, Salido M, Espinet B, Astier L, Domingo A, Granada I, Millà F, Carrió A, Costa D, Luño E, Hernández JM, Campo E, Florensa L, Ferrer A, Salar A, Bellosillo B, Besses C, Serrano S, Solé F (2008) New chromosomal alterations in a series of 23 splenic marginal zone lymphoma patients revealed by Spectral Karyotyping (SKY). Leuk Res 32:727-736.
  • Bernicot I, Douet-Guilbert N, Le Bris MJ, Morice P, Abgrall JF, Berthou C, Morel F, De Braekeleer M (2005) Characterization of IGH rearrangements in non-Hodgkin's B-cell lymphomas by fluorescence in situ hybridization. Anticancer Res 25:3179-3182
  • Bernicot I, Douet-Guilbert N, Le Bris MJ, Herry A, Morel F, De Braekeleer M (2007) Molecular cytogenetics of IGH rearrangements in non-Hodgkin B-cell lymphoma. Cytogenet Genome Res 118:345-352.
  • Chaganti SR, Chen W, Parsa N, Offit K, Louie DC, Dalla-Favera R, Chaganti RS (1998) Involvement of BCL6 in chromosomal aberrations affecting band 3q27 in B-cell non-Hodgkin lymphoma. Genes Chromosomes Cancer 23: 323-327.
  • Dave BJ, Nelson M, Pickering DL, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Sanger WG (2002) Cytogenetic characterization of diffuse large cell lymphoma using multi-color fluorescence in situ hybridization. Cancer Genet Cytogenet 132: 125-132.
  • Zhang D, Denley RC, Filippa DA, Teruya-Feldstein J. (2009) ALK-positive diffuse large B-cell lymphoma with the t(2;17)(p23;q23). Appl. Immunohistochem Mol Morphol 17:172-177.
  • Ferti AD, Panani AD, Stamouli MI, Rondogianni DP, Raptis SA, Young BD (2004) M-FISH in gastric lymphoma. Cancer Genet Cytogenet 155: 63-66.
  • Fujiwara T, Ichinohasama R, Miura I, Sugawara T, Harigae H, Yokoyama H, Takahashi S, Tomiya Y, Yamada M, Ishizawa K, Kameoka J, Sasaki T (2005) Primary effusion lymphoma of the pericardial cavity carrying t(1;22)(q21;q11) and t(14;17)(q32;q23). Cancer Genet Cytogenet 156:49-53.
  • Fujimoto Y, Nomura K, Fukada S, Shimizu D, Shimura K, Matsumoto Y, Horiike S, Nishida K, Shimazaki C, Abe M, Taniwaki M (2008) Immunoglobulin light chain gene translocations in non-Hodgkin's lymphoma as assessed by fluorescence in situ hybridisation. Eur J Haematol 80:143-150
  • Gascoyne RD, Lamant L, Martin-Subero JI, Lestou VS, Harris NL, Müller-Hermelink HK, Seymour JF, Campbell LJ, Horsman DE, Auvigne I, Espinos E, Siebert R, Delsol G (2003) ALK-positive diffuse large B-cell lymphoma is associated with Clathrin-ALK rearrangements: report of 6 cases. Blood 102:2568-2573
  • Gruszka-Westwood AM, Atkinson S, Summersgill BM, Shipley J, Elnenaei MO, Jain P, Hamoudi RA, Kaeda JS, Wotherspoon AC, Matutes E, Catovsky D (2002) Unusual case of leukemic mantle cell lymphoma with amplified CCND1/IGH fusion gene. Genes Chromosomes Cancer 33: 206-212.
  • Harigae H, Ichinohasama R, Miura I, Kameoka J, Meguro K, Miyamura K, Sasaki O, Ishikawa I, Takahashi S, Kaku M, Sasaki T (2002) Primary marginal zone lymphoma of the thymus accompanied by chromosomal anomaly 46,X,dup(X)(p11p22). Cancer Genet Cytogenet 133 :1142-1147.
  • Havelange V, Ameye G, Théate I, Callet-Bauchu E, Mugneret F, Michaux L, Dastugue N, Penther D, Barin C, Collonge-Rame MA, Baranger L, Terré C, Nadal N, Lippert E, Laï JL, Cabrol C, Tigaud I, Herens C, Hagemeijer A, Raphael M, Libouton JM, Poirel HA; GFCH (Groupe Francophone de Cytogénétique Hématologique) (2013) Patterns of genomic aberrations suggest that Burkitt lymphomas with complex karyotype are distinct from other aggressive B-cell lymphomas with MYC rearrangement. Genes Chromosomes Cancer 52: 81-92.
  • Hilgenfeld E, Padilla-Nash H, Schröck E, Ried T (1999) Analysis of B-cell neoplasias by spectral karyotyping (SKY). Curr Top Microbiol Immunol 246: 169-174.
  • Itoyama T, Nanjungud G, Chen W, Dyomin VG, Teruya-Feldstein J, Jhanwar SC, Zelenetz AD, Chaganti RS (2002) Molecular cytogenetic analysis of genomic instability at the 1q12-22 chromosomal site in B-cell non-Hodgkin lymphoma. Genes Chromosomes Cancer 35: 318-328.
  • Jamet D, Marzin Y, Douet-Guilbert N, Morel F, Le Bris MJ, Herry A, Banzakour S, Bourquard P, Morice P, Abgrall JF, Berthou C, De Braekeleer M (2005) Jumping translocations in multiple myeloma. Cancer Genet Cytogenet 161:159-163
  • Jurkowska M, Zekanowski C, Malinowska I, Zielenska M (2001) [Molecular diagnosis of lymphomas and leukaemias].Med Wieku Rozwoj V(2): 113-134. Polish
  • Kakazu N, Kito K, Hitomi T, Oita J, Nishida K, Masuda K, Miki T, Abe T (2000) Characterization of complex chromosomal abnormalities in B-cell lymphoma by a combined spectral karyotyping (SKY) analysis and fluorescence in situ hybridization (FISH) using a 14q telomere probe. Am J Hematol 65: 291-297.
  • Kiefer T, Schüler F, Knopp A, Wimmer M, Hirt C, Schaefer HE, Dölken G (2007) A human Burkitt's lymphoma cell line carrying t(8;22) and t(14;18) translocations. Ann Hematol 86:821-830
  • Kobayashi S, Taki T, Chinen Y, Tsutsumi Y, Ohshiro M, Kobayashi T, Matsumoto Y, Kuroda J, Horiike S, Nishida K, Taniwaki M (2011) Identification of IGHCδ-BACH2 fusion transcripts resulting from cryptic chromosomal rearrangements of 14q32 with 6q15 in aggressive B-cell lymphoma/leukemia. Genes Chromosomes Cancer 50:207-216.
  • Kuo SH, Weng WH, Chen ZH, Hsu PN, Wu MS, Lin CW, Jeng HJ, Yeh KH, Tsai HJ, Chen LT, Cheng AL (2011) Establishment of a novel MALT lymphoma cell line, ma-1, from a patient with t(14;18)(q32;q21)-positive Helicobacter pylori-independent gastric MALT lymphoma. Genes Chromosomes Cancer 50:908-921.
  • Kuroda J, Kimura S, Akaogi T, Hayashi H, Nishida K, Kakazu N, Abe T (2000) Aggressive natural killer cell leukemia/lymphoma: a comprehensive cytogenetic study by spectral karyotyping. Ann Hematol 79: 519-522.
  • Kuo SH, Weng WH, Chen ZH, Hsu PN, Wu MS, Lin CW, Jeng HJ, Yeh KH, Tsai HJ, Chen LT, Cheng AL (2011) Establishment of a novel MALT lymphoma cell line, ma-1, from a patient with t(14;18)(q32;q21)-positive Helicobacter pylori-independent gastric MALT lymphoma. Genes Chromosomes Cancer 50:908-921.
  • Lamant L, Gascoyne RD, Duplantier MM, Armstrong F, Raghab A, Chhanabhai M, Rajcan-Separovic E, Raghab J, Delsol G, Espinos E (2003) Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma. Genes Chromosomes Cancer 37: 427-432.
  • Lange K, Gadzicki D, Schlegelberger B, Göhring G (2010) Recurrent involvement of heterochromatic regions in multiple myeloma-a multicolor FISH study. Leuk Res 34:1002-1006.
  • La Starza R, Crescenzi B, Pierini V, Romoli S, Gorello P, Brandimarte L, Matteucci C, Kropp MG, Barba G, Martelli MF, Mecucci C (2007) A common 93-kb duplicated DNA sequence at 1q21.2 in acute lymphoblastic leukemia and Burkitt lymphoma. Cancer Genet Cytogenet 175:73-76.
  • Lestou VS, Gascoyne RD, Salski C, Connors JM, Horsman DE (2002) Uncovering novel inter- and intrachromosomal chromosome 1 aberrations in follicular lymphomas by using an innovative multicolor banding technique. Genes Chromosomes Cancer, 34: 201-210.
  • MacLeod RAF, Spitzer D, Bar-Am I, Sylvester JE, Kaufmann M, Wernich A, Drexler HG (2000) Karyotypic dissection of Hodgkin's disease cell lines reveals ectopic subtelomeres and ribosomal DNA at sites of multiple jumping translocations and genomic amplification. Leukemia 14, 1803-1814.
  • MacLeod RA, Drexler HG (2013) Classical and molecular cytogenetic analysis. Methods Mol Biol 946:39-60.
  • Mader A, Bruderlein S, Wegener S, Melzner I, Popov S, Muller-Hermelink HK, Barth TF, Viardot A, Möller P (2007) U-HO1, a new cell line derived from a primary refractory classical Hodgkin lymphoma. Cytogenet Genome Res 119:204-210
  • Mao X, Lillington DM, Czepulkowski B, Russell-Jones R, Young BD, Whittaker S (2003) Molecular cytogenetic characterization of Sezary syndrome. Genes Chromosomes Cancer 36: 250-260.
  • Maravelaki S, Burford A, Wotherspoon A, Joshi R, Matutes E, Catovsky D, Brito-Babapulle V (2004) Molecular cytogenetic study of a mantle cell lymphoma with a complex translocation involving the CCND1 (11q13) region. Cancer Genet Cytogenet 154:67-71.
  • Minakata D, Sato K, Ikeda T, Toda Y, Ito S, Mashima K, Umino K, Nakano H, Yamasaki R, Morita K, Kawasaki Y, Sugimoto M, Yamamoto C, Ashizawa M, Hatano K, Oh I, Fujiwara SI, Ohmine K, Kawata H, Muroi K, Miura I, Kanda Y (2018) A leukemic double-hit follicular lymphoma associated with a complex variant translocation, t(8;14;18)(q24;q32;q21), involving BCL2, MYC, and IGH. Cancer Genet 220: 44-48.
  • Nagoshi H, Taki T, Hanamura I, Nitta M, Otsuki T, Nishida K, Okuda K, Sakamoto N, Kobayashi S, Yamamoto-Sugitani M, Tsutsumi Y, Kobayashi T, Matsumoto Y, Horiike S, Kuroda J, Taniwaki M (2012) Frequent PVT1 rearrangement and novel chimeric genes PVT1-NBEA and PVT1-WWOX occur in multiple myeloma with 8q24 abnormality. Cancer Res 72:4954-4962.
  • Nanjangud G, Rao PH, Hegde A, Teruya-Feldstein J, Donnelly G, Qin J, Jhanwar SC, Zelenetz AD, Chaganti RS (2002) Spectral karyotyping identifies new rearrangements, translocations, and clinical associations in diffuse large B-cell lymphoma. Blood 99: 2554-2561.
  • Nanjangud G, Rao PH, Teruya-Feldstein J, Donnelly G, Qin J, Mehra S, Jhanwar SC, Zelenetz AD, Chaganti RS (2007) Molecular cytogenetic analysis of follicular lymphoma (FL) provides detailed characterization of chromosomal instability associated with the t(14;18)(q32;q21) positive and negative subsets and histologic progression. Cytogenet Genome Res 118:337-344
  • Ng MH, Wong N, Tsang KS, Cheng SH, Chung YF, Lo KW (2001) Recurrent chromosomal rearrangements involving breakpoints 3p21 and 19q13 in Chinese IgD multiple myeloma detected by G-banding and multicolor spectral karyotyping: a review of IgD karyotype literature. Hum Pathol 32: 1016-1020.
  • Nordgren A, Sorensen AG, Tinggaard-Pedersen N, Blennow E, Larsson C, Lagercrantz S (2000) New chromosomal breakpoints in non-Hodgkin's lymphomas revealed by spectral karyotyping and G-banding. Int J Mol Med 5: 485-492.
  • Nomura K, Kanda-Akano Y, Shimizu D, Okuda T, Yoshida N, Matsumoto Y, Nishida K, Taki T, Yokota S, Horiike S, Taniwaki M (2005) An additional segment at 1p36 derived from der(18)t(14;18) in patients with diffuse large B-cell lymphomas transformed from follicular lymphoma. Ann Hematol 84:474-476
  • Okano A, Nakano S, Namura K, Yamada N, Uchida R, Fuchida S, Okamoto M, Ochiai N, Shimazaki C (2005) Unique three-way translocation, t(3;14;18)(q27;q32;q21), in follicular lymphoma. Cancer Genet Cytogenet 159: 174-176.
  • Okhowat R, Dorner S, Hinterberger W, Fonatsch C (2003) Unusual karyotype aberrations involving 2p12, 3q27, 18q21, 8q24, and 14q32 in a patient with non-Hodgkin lymphoma/acute lymphoblastic leukemia. Cancer Genet Cytogenet 142: 60-64.
  • Ortega M, Mallo M, Solé F, Sánchez-Morata C, López-Andreoni L, Martínez-Morgado N, Gironella M, Valcárcel D, Vallespí T (2013) 5q- syndrome and multiple myeloma diagnosed simultaneously and successful treated with lenalidomide. Leuk Res 37:1248-1250
  • Ouyang J, Yin HL, Lu ZF, Zhou HB, Zhou XJ (2009) [Primary Burkitt lymphoma of the seminal vesicle: a case report and review of the literature]. Zhonghua Nan Ke Xue 15:733-737.
  • Poppe B, De Paepe P, Michaux L, Dastugue N, Bastard C, Herens C, Moreau E, Cavazzini F, Yigit N, Van Limbergen H, De Paepe A, Praet M, De Wolf-Peeters C, Wlodarska I, Speleman F (2005) PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements. Genes Chromosomes Cancer 44:218-223.
  • Ramos S, Navarrete-Meneses P, Molina B, Cervantes-Barragán DE, Lozano V, Gallardo E, Marchetti F, Frias S (2018) Genomic chaos in peripheral blood lymphocytes of Hodgkin's lymphoma patients one year after ABVD chemotherapy/radiotherapy. Environ Mol Mutagen 59:755-768.
  • Reddy KS, Parsons L, Mak L, Chan JA (2001) An hsr on chromosome 7 was shown to be an insertion of four copies of the 11q23 MLL gene region in an HIV-related lymphoma. Cancer Genet Cytogenet 129:107-111.
  • Salaverria I, Espinet B, Carrió A, Costa D, Astier L, Slotta-Huspenina J, Quintanilla-Martinez L, Fend F, Solé F, Colomer D, Serrano S, Miró R, Beà S, Campo E (2008) Multiple recurrent chromosomal breakpoints in mantle cell lymphoma revealed by a combination of molecular cytogenetic techniques. Genes Chromosomes Cancer 47:1086-1097.
  • Sawyer JR (2005) Multicolor spectral karyotyping in multiple myeloma. Methods Mol Med 113:49-58.
  • Sawyer JR, Tricot G, Lukacs JL, Binz RL, Tian E, Barlogie B, Shaughnessy J Jr (2005) Genomic instability in multiple myeloma: evidence for jumping segmental duplications of chromosome arm 1q. Genes Chromosomes Cancer. 42: 95-106.
  • Seok Y, Kim J, Choi JR, Kim YR, Park SJ, Kim SJ, Song J, Lee KA (2012) CD5-negative blastoid variant mantle cell lymphoma with complex CCND1/IGH and MYC aberrations. Ann Lab Med 32:95-98.
  • Stejskalova E, Jarosova M, Kabickova E, Smelhaus V, Mrhalova M, Kodet R (2006) Primary mediastinal (thymic) large B-cell lymphoma with a der(14)t(8;14)(q24;q32) and a translocation of MYC to the derivative chromosome 14 with a deleted IgH locus. Cancer Genet Cytogenet 170:158-162.
  • Tamura A, Miura I, Iida S, Yokota S, Horiike S, Nishida K, Fujii H, Nakamura S, Seto M, Ueda R, Taniwaki M (2001) Interphase detection of immunoglobulin heavy chain gene translocations with specific oncogene loci in 173 patients with B-cell lymphoma. Cancer Genet Cytogenet 129: 1-9.
  • Wan TS, Ma SK, Chan GC, Ching LM, Ha SY, Chan LC (2000) Complex cytogenetic abnormalities in T-lymphoblastic lymphoma: resolution by spectral karyotyping. Cancer Genet Cytogenet 118: 24-27.
  • Wei P, Zhang YL, Xie JL, Zheng YY, Liu W, Zhou XG (2018) [Clinicopathologic characteristics of Burkitt-like lymphoma with chromosome 11q aberration]. Zhonghua Bing Li Xue Za Zhi 47:176-179. Chinese.
  • W inrow CJ, Pankratz DG, Vibat CR, Bowen TJ, Callahan MA, Warren AJ, Hilbush BS, Wynshaw-Boris A, Hasel KW, Weaver Z, Lockhart DJ, Barlow C (2005) Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas. Hum Mol Genet 14:2671-2684.
  • Wong N, Wong KF, Chan JK, Johnson PJ (2000) Chromosomal translocations are common in natural killer-cell lymphoma/leukemia as shown by spectral karyotyping. Hum Pathol 31: 771-774.
  • Yamamoto K, Nakamura Y, Arai H, Aoyagi M, Saito K, Furusawa S, Mitani K (2001) Translocation (14;19)(q32;q13) detected by spectral karyotyping and lack of BCL3 rearrangement in CD5-positive B-cell lymphoma associated with hemophagocytic syndrome.Cancer Genet Cytogenet 130: 38-41.
  • Yamamoto K, Okamura A, Minagawa K, Yakushijin K, Urahama N, Gomyo H, Shimoyama M, Itoh M, Matsui T (2003) A novel t(2;6)(p12;q23) appearing during transformation of follicular lymphoma with t(18;22)(q21;q11) to diffuse large cell lymphoma. Cancer Genet Cytogenet 147: 128-133
  • Yamamoto K, Ono K, Katayama Y, Shimoyama M, Matsui T (2007) Derivative (3)t(3;18)(q27;q21)t(18;16)(q21;?) involving the BCL2 and BCL6 genes in follicular lymphoma with t(3;14;18)(q27;q32;q21). Cancer Genet Cytogenet 179:69-75
  • Yamamoto K, Matsuoka H, Yakushijin K, Funakoshi Y, Okamura A, Hayashi Y, Minami H (2011) A novel five-way translocation, t(3;9;13;8;14)(q27;p13;q32;q24;q32), with concurrent MYC and BCL6 rearrangements in a primary bone marrow B-cell lymphoma. Cancer Genet 204:501-506.
  • Zattara-Cannoni H, Dufour H, Lepidi H, Chatel C, Grisoli F, Vagner-Capodano AM (1998) Hidden chromosome abnormalities in a primary central nervous system lymphoma detected by multicolor spectral karyotyping. Cancer Genet Cytogenet 107: 98-101.

Solid tumors

  • Abla O, Dror Y, Shago M (2007) Translocation (X;10) in a child with therapy-related acute myeloid leukemia following chemotherapy for Ewing's Sarcoma. Cancer Genet Cytogenet 178:168-169
  • Adeyinka A, Kytölä S, Mertens F, Pandis N, Larsson C (2000) Spectral karyotyping and chromosome banding studies of primary breast carcinomas and their lymph node metastases. Int J Mol Med 5: 235-240.
  • Amant F, Tousseyn T, Coenegrachts L, Decloedt J, Moerman P, Debiec-Rychter M (2011) Case report of a poorly differentiated uterine tumour with t(10;17) translocation and neuroectodermal phenotype. Anticancer Res 31:2367-2371.
  • Ashman JN, Brigham J, Cowen ME, Bahia H, Greenman J, Lind M, Cawkwell L (2002) Chromosomal alterations in small cell lung cancer revealed by multicolour fluorescence in situ hybridization. Int J Cancer 102:230-236.
  • Barenboim-Stapleton L, Yang X, Tsokos M, Wigginton JM, Padilla-Nash H, Ried T, Thiele CJ (2005) Pediatric pancreatoblastoma: histopathologic and cytogenetic characterization of tumor and derived cell line. Cancer Genet Cytogenet 157:109-117
  • Barnard M, Bayani J, Grant R, Teshima I, Thorner P, Squire J (2000) Use of multicolor spectral karyotyping in genetic analysis of pleuropulmonary blastoma. Pediatr Dev Pathol. 3: 479-486
  • Bayani J, Zielenska M, Marrano P, Kwan Ng Y, Taylor MD, Jay V, Rutka JT, Squire JA (2000) Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping. J Neurosurg 93: 437-448.
  • Bayani J, Zielenska M, Pandita A, Al-Romaih K, Karaskova J, Harrison K, Bridge JA, Sorensen P, Thorner P, Squire JA (2003) Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17, and 20 in osteosarcomas. Genes Chromosomes Cancer 36: 7-16
  • Behboudi A, Enlund F, Winnes M, Andren Y, Nordkvist A, Leivo I, Flaberg E, Szekely L, Makitie A, Grenman R, Mark J, Stenman G (2006) Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. Genes Chromosomes Cancer 45: 470-481
  • Berrieman HK, Ashman JN, Cowen ME, Greenman J, Lind MJ, Cawkwell L (2004) Chromosomal analysis of non-small-cell lung cancer by multicolour fluorescent in situ hybridisation. Br J Cancer 90:900-905
  • Bigner SH, Schröck E (1997) Molecular cytogenetics of brain tumors. J Neuropathol Exp Neurol 56: 1173-1181
  • Botrus G, Sciot R, Debiec-Rychter M (2006) Cutaneous aneurysmal fibrous histiocytoma with a t(12;19)(p12;q13) as the sole cytogenetic anomaly. Cancer Genet Cytogenet 164:155-158.
  • Brassesco MS, Cortez MA, Valera ET, Engel EE, Nogueira-Barbosa MH, Becker AP, Scrideli CA, Tone LG (2010) Cryptic SYT/SXX1 fusion gene in high-grade biphasic synovial sarcoma with unique complex rearrangement and extensive BCL2 overexpression.Cancer Genet Cytogenet 196:189-193.
  • Brassesco MS, Valera ET, Bonilha TA, Scrideli CA, Carvalho de Oliveira J, Pezuk JA, Barros Silva GE, Costa RS, Tone LG (2011) Secondary PSF/TFE3-associated renal cell carcinoma in a child treated for genitourinary rhabdomyosarcoma. Cancer Genet, 204:108-110.
  • Brothman AR, Xhu XL, Maxwell T, Cui J, Deubler DA (1999) Advances in the cytogenetics of prostate cancer. J. Assoc. Genetic Technologists 25: 1-6.
  • Campos M, Prior C, Warleta F, Zudaire I, Ruíz-Mora J, Catena R, Calvo A, Gaforio JJ (2008) Phenotypic and genetic characterization of circulating tumor cells by combining immunomagnetic selection and FICTION techniques. J Histochem Cytochem 56:667-675.
  • Carlotti Jr CG, Drake JM, Hladky J, Teshima I, Becker LE, Rutka JT (1999) Primary Ewing's sarcoma of the skull in children. Utility of molecular diagnostics, surgery and adjuvant therapies. Pediatr Neurosurg 31: 307-315.
  • Chen Z, Coffin CM, Smith LM, Issa B, Arndt S, Shepard R, Brothman L, Stratton J, Brothman AR, Zhou H (2001) Cytogenetic-clinicopathologic correlations in rhabdomyosarcoma: a report of five cases. Cancer Genet Cytogenet. 131:31-36.
  • Chyhrai A, Sanjmyatav J, Gajda M, Reichelt O, Wunderlich H, Steiner T, Tanović E, Junker K (2010) Multi-colour FISH on preoperative renal tumour biopsies to confirm the diagnosis of uncertain renal masses. World J Urol 28:269-274.
  • Clark J, Edwards S, Feber A, Flohr P, John M, Giddings I, Crossland S, Stratton MR, Wooster R, Campbell C, et al. (2003) Genome-wide screening for complete genetic loss in prostate cancer by comparative hybridization onto cDNA microarrays. Oncogene 22(8):1247-1252
  • Cohen IJ, Issakov J, Avigad S, Stark B, Meller I, Zaizov R, Bar-Am I (1997) Synovial sarcoma of bone delineated by spectral karyotyping. Lancet 350: 1679-1680.
  • Cohen N, Betts DR, Trakhtenbrot L, Niggli FK, Amariglio N, Brok-Simoni F, Rechavi G, Meitar D (2001) Detection of unidentified chromosome abnormalities in human neuroblastoma by spectral karyotyping (SKY). Genes Chromosomes Cancer 31: 201-208.
  • Cohen N, Betts DR, Tavori U, Toren A, Ram T, Constantini S, Grotzer MA, Amariglio N, Rechavi G, Trakhenbrot L (2004) Karyotypic evolution pathsways in medulloblastoma/primitive neuroectodermal tumor determined with a combination of spectral karyotyping, G-banding, and fluorescence in situ hybridization. Cancer Genet Cytogenet 149: 44-52.
  • Cowell JK, Matsui S, Wang YD, LaDuca J, Conroy J, McQuaid D, Nowak NJ (2004) Application of bacterial artificial chromosome array-based comparative genomic hybridization and spectral karyotyping to the analysis of glioblastoma multiforme. Cancer Genet Cytogenet 151:36-51.
  • da Silva FE, Cordeiro AB, Nagamachi CY, Pieczarka JC, Rens W, Weise A, Liehr T, Mkrtchyan H, Anselmo NP, de Oliveira EHC (2010) A case of aggressive medulloblastoma with multiple recurrent chromosomal alterations. Cancer Genet Cytogenet 196:198-200.
  • Debiec-Rychter M, Hagemeijer A, Raf S (2003) Spindle-cell rhabdomysarcoma with 2q36~q37 involvement. Cancer Genet Cytogenet 140: 62-65.
  • Dennis TR, Stock AD (1999) A molecular cytogenetic study of chromosome 3 rearrangements in small cell lung cancer: consistent involvement of chromosome band 3q13.2. Cancer Genet Cytogenet 113: 134-140.
  • Eils R, Uhrig S, Saracoglu K, Satzler K, Bolzer A, Petersen I, Chassery J, Ganser M, Speicher MR (1998) An optimized, fully automated system for fast and accurate identification of chromosomal rearrangements by multiplex-FISH (M-FISH). Cytogenet Cell Genet 82: 160-171.
  • Fadl-Elmula I, Kytola S, Pan Y, Lui WO, Derienzo G, Forsberg L, Mandahl N, Gorunova L, Bergerheim US, Heim S, Larsson C (2001) Characterization of chromosomal abnormalities in uroepithelial carcinomas by G-banding, spectral karyotyping and FISH analysis. Int J Cancer 92: 824-831.
  • Ferber MJ, Eilers P, Schuuring E, Fenton JA, Fleuren GJ, Kenter G, Szuhai K, Smith DI, Raap AK, Brink AA (2004) Positioning of cervical carcinoma and Burkitt lymphoma translocation breakpoints with respect to the human papillomavirus integration cluster in FRA8C at 8q24.13. Cancer Genet Cytogenet ;154:1-9.
  • Ferti AD, Stamouli MJ, Panani AD, Raptis SA, Young BD (2004) Molecular cytogenetic analysis of breast cancer: a combined multicolor fluorescence ub situ hybridization and G-banding study of uncultured tumor cells. Cancer Genet Cytogenet 149: 28-37.
  • Gadji M, Crous-Tsanaclis AM, Mathieu D, Mai S, Fortin D, Drouin R (2014) A new der(1;7)(q10;p10) leading to a singular 1p loss in a case of glioblastoma with oligodendroglioma component. Neuropathology 34:170-178.
  • Ghadimi BM, Schröck E, Walker RL, Wangsa D, Jauho A, Meltzer PS, Ried T (1999) Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas. Am J Pathol 154: 525-536.
  • Gil Z, Fliss DM, Voskoboimik N, Trejo-Leider L, Khafif A, Yaron Y, Orr-Urtreger A (2003) Two novel translocations, t(2;4)(q35;q31) and t(X;12)(q22;q24), as the only karyotypic abnormalities in a malignant peripheral nerve sheath tumor of the skull base. Cancer Genet Cytogenet 145: 139-143.
  • Gisselsson D, Pettersson L, Hoglund M, Heidenblad M, Gorunova L, Wiegant J, Mertens F, Dal Cin P, Mitelman F, Mandahl N (2000) Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity. Proc Natl Acad Sci U S A 97: 5357-5362.
  • Goldstein M, Rennert H, Bar-Shira A, Burstein Y, Yaron Y, Orr-Urtreger A (2003) Combined cytogenetic and array-based comparative genomic hybridization analyses of Wilms tumors: amplification and overexpression of the multidrug resistance associated protein 1 gene (MRP1) in a metachronous tumor. Cancer Genet Cytogenet 141: 120-127.
  • Grade M, Becker H, Liersch T, Ried T, Ghadimi BM (2006) Molecular cytogenetics: genomic imbalances in colorectal cancer and their clinical impact. Cell Oncol 28:71-84
  • Granzow M, Popp S, Weber S, Schoell B, Holtgreve-Grez H, Senf L, Hager D, Boschert J, Scheurlen W, Jauch A (2001) Isochromosome 1q as an early genetic event in a child with intracranial ependymoma characterized by molecular cytogenetics.Cancer Genet Cytogenet 130: 79-83.
  • Griffin CA, Hawkins AL, Dvorak C, Henkle C, Ellingham T, Perlman EJ (1999) Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. Cancer Res 59: 2776-2780.
  • Gunawan B, Mirzaie M, Schulten HJ, Heidrich B, Fuzesi L (2000) Molecular cytogenetic analysis of two primaray squamous cell carcinomas of the lung using multicolor fluorescence in situ hybridization. Virchows Arch 439: 85-89.
  • Gorunova L, Vult von Steyern F, Storlazzi CT, Bjerkehagen B, Follerås G, Heim S, Mandahl N, Mertens F (2009) Cytogenetic analysis of 101 giant cell tumors of bone: Nonrandom patterns of telomeric associations and other structural aberrations. Genes Chromosomes Cancer 48:583-602.
  • Gutiérrez NC, Camps J, Hernández JM, García JL, Prat E, González MB, Miró R, San Miguel JF (2003) Multicolor fluorescence in situ hybridization studies in multiple myeloma and monoclonal gammopathy of undetermined significance. Hematol J 4:67-70
  • Ida CM, Rolig KA, Hulshizer RL, Van Dyke DL, Randolph JL, Jenkins RB, Nascimento AG, Oliveira AM (2007) Myxoinflammatory fibroblastic sarcoma showing t(2;6)(q31;p21.3) as a sole cytogenetic abnormality. Cancer Genet Cytogenet 177:139-142
  • Jinawath N, Morsberger L, Norris-Kirby A, Williams LM, Yonescu R, Argani P, Griffin CA, Murphy KM (2010) Complex rearrangement of chromosomes 1, 7, 21, 22 in Ewing sarcoma. Cancer Genet Cytogenet 201:42-47.
  • Haddadin MH, Hawkins AL, Long P, Morsberger LA, Depew D, Epstein JI, Griffin CA (2003) Cytogenetic study of malignant triton tumor: a case report. Cancer Genet Cytogenet. 144: 100-105.
  • Hazelbag HM, Szuhai K, Tanke HJ, Rosenberg C, Hogendoorn PC (2004) Primary synovial sarcoma of the heart: a cytogenetic and molecular genetic analysis combining RT-PCR and COBRA-FISH of a case with a complex karyotype. Mod Pathol 17:1434-1439
  • Henkle CT, Hawkins AL, McCarthy EF, Griffin CA (2004) Clear cell sarcoma case report: complex karyotype including t(12;22) in primary and metastatic tumor. Cancer Genet Cytogenet 149: 63-67.
  • Holland H, Koschny R, Krupp W, Meixensberger J, Bauer M, Kirsten H, Ahnert P (2007) Comprehensive cytogenetic characterization of an esthesioneuroblastoma. Cancer Genet Cytogenet 173:89-96
  • Holland H, Koschny R, Krupp W, Meixensberger J, Bauer M, Schober R, Kirsten H, Ganten TM, Ahnert P (2007) Cytogenetic and molecular biological characterization of an adult medulloblastoma. Cancer Genet Cytogenet 178:104-113.
  • Holland H, Livrea M, Ahnert P, Koschny R, Kirsten H, Meixensberger J, Bauer M, Schober R, Fritzsch D, Krupp W (2011) Intracranial hemangiopericytoma: Case study with cytogenetics and genome wide SNP-A analysis. Pathol Res Pract 2011 207:310-316.
  • Holland H, Mocker K, Ahnert P, Kirsten H, Hantmann H, Koschny R, Bauer M, Schober R, Scholz M, Meixensberger J, Krupp W (2011) High resolution genomic profiling and classical cytogenetics in a group of benign and atypical meningiomas. Cancer Genet 204:541-549.
  • Holland H, Ahnert P, Koschny R, Kirsten H, Bauer M, Schober R, Meixensberger J, Fritzsch D, Krupp W (2012) Detection of novel genomic aberrations in anaplastic astrocytomas by GTG-banding, SKY, locus-specific FISH, and high density SNP-array. Pathol Res Pract 208:325-330.
  • Hosch S, Kraus J, Scheunemann P, Izbicki JR, Schneider C, Schumacher U, Witter K, Speicher MR, Pantel K (2000) Malignant potential and cytogenetic characteristics of occult disseminated tumor cells in esophageal cancer. Cancer Res 60: 6836-6840.
  • Hosoi H, Kakazu N, Konishi E, Tsuchihashi Y, Hada S, Amaya E, Nakabayahi Y, Misawa-Furihata A, Tabata-Maruyama H, Iehara T, Sugimoto T, Yamane H, Yamasaki M, Shiwaku K, Yanagisawa A, Ono M, Tokiwa K, Iwai N, Hashiba M, Abe T, Sawada T (2009) A novel PAX3 rearrangement in embryonal rhabdomyosarcoma. Cancer Genet Cytogenet 189:98-104.
  • Hoshino M, Ogose A, Kawashima H, Izumi T, Hotta T, Hatano H, Morita T, Otsuka H, Umezu H, Yanoma S, Tsukuda M, Endo N (2009) Molecular analyses of cell origin and detection of circulating tumor cells in the peripheral blood in alveolar soft part sarcoma. Cancer Genet Cytogenet 190:75-80.
  • Hurst CD, Fiegler H, Carr P, Williams S, Carter NP, Knowles MA (2004) High-resolution analysis of genomic copy number alterations in bladder cancer by microarray-based comparative genomic hybridization. Oncogene 23:2250-2263
  • Iliszko M, Rys J, Wozniak A, Chosia M, Sciot R, Debiec-Rychter M, Limon J (2009) Complex tumor-specific t(X;18) in seven synovial sarcoma tumors. Cancer Genet Cytogenet. 189:118-121.
  • Inazawa J, Ariyama Y, Mori T, Sakakura T, Abe T (1997) [Analysis of genomic alterations in neoplastic tumors by CGH and SKY]. Tanpakushitsu Kakusan Koso 42: 2767-2772 [articel in Japanese].
  • Ishiguro M, Iwasaki H, Takeshita M, Hirose Y, Kaneko Y (2006) A cytogenetic analysis in two cases of malignant peripheral nerve sheath tumor showing hypodiploid karyotype. Oncol Rep 16:225-232
  • Italiano A, Attias R, Aurias A, Perot G, Burel-Vandenbos F, Otto J, Venissac N, Pedeutour F (2006) Molecular cytogenetic characterization of a metastatic lung sarcomatoid carcinoma: 9p23 neocentromere and 9p23 approximately p24 amplification including JAK2 and JMJD2C. Cancer Genet Cytogenet 167: 122-130.
  • Jallepalli PV, Lengauer C (2001) Chromosome segregation and cancer: cutting through the mystery. Nature Reviews Cancer 1: 109-117
  • Jin C, Martins C, Jin Y, Wiegant J, Wennerberg J, Dictor M, Gisselsson D, Strombeck B, Fonseca I, Mitelman F, Tanke HJ, Hoglund M, Mertens F (2001) Characterization of chromosome aberrations in salivary gland tumors by FISH, including multicolor COBRA-FISH. Genes Chromosomes Cancer 30: 161-167.
  • Jin Y, Jin C, Law S, Chu KM, Zhang H, Strombeck B, Yuen AP, Kwong YL (2004) Cytogenetic and fluorescence in situ hybridization characterization of clonal chromosomal aberrations and CCND1 amplification in esophageal carcinomas. Cancer Genet Cytogenet 148: 21-28.
  • Jin Y, Jin C, Lv M, Tsao SW, Zhu J, Wennerberg J, Mertens F, Kwong YL (2005) Karyotypic evolution and tumor progression in head and neck squamous cell carcinomas. Cancer Genet Cytogenet 156:1-7.
  • Joyama S, Ueda T, Shimizu K, Kudawara I, Mano M, Funai H, Takemura K, Yoshikawa H (2001) Chromosome rearrangement at 17q25 and xp11.2 in alveolar soft-part sarcoma: A case report and review of the literature. Cancer 86: 1246-1250.
  • Junker K, Fritsch T, Hartmann A, Schulze W, Schubert J (2006) Multicolor fluorescence in situ hybridization (M-FISH) on cells from urine for the detection of bladder cancer. Cytogenet Genome Res 114:279-283.
  • Kakazu N, Abe T (1998) Cytogenetic analysis of chromosome abnormalities in human cancer using SKY. Experimental Medicine (Jikken Igaku) 16: 1638-1641.
  • Kanayama Ho, Lui WO, Takahashi M, Naroda T, Kedra D, Wong FK, Kuroki Y, Nakahori Y, Larsson C, Kagawa S, Teh BT (2001) Association of a novel constitutional translocation t(1q;3q) with familial renal cell carcinoma. J Med Genet 38: 165-170.
  • Kawashima H, Ogose A, Umezu H, Hotta T, Tohyama T, Tsuchiya M, Endo N (2007) Ossifying fibromyxoid tumor of soft parts with clonal chromosomal aberrations. Cancer Genet Cytogenet 176:156-160.
  • Kempski HM, Austin N, Chatters SJ, Toomey SM, Chalker J, Anderson J, Sebire NJ (2006) Previously unidentified complex cytogenetic changes found in a pediatric case of solid-pseudopapillary neoplasm of the pancreas. Cancer Genet Cytogenet 164: 54-60.
  • Krupp W, Geiger K, Schober R, Siegert G, Froster UG (2004) Cytogenetic and molecular cytogenetic analyses in diffuse astrocytomas. Cancer Genet Cytogenet.153(1):32-8.
  • Krupp W, Holland H, Koschny R, Bauer M, Schober R, Kirsten H, Livrea M, Meixensberger J, Ahnert P (2008) Genome-wide genetic characterization of an atypical meningioma by single-nucleotide polymorphism array-based mapping and classical cytogenetics. Cancer Genet Cytogenet 184:87-93.
  • Kuzniacka A, Mertens F, Strombeck B, Wiegant J, Mandahl N (2004)  Combined binary ratio labeling fluorescence in situ hybridization analysis of chordoma. Cancer Genet Cytogenet 151: 178-181.
  • Kytölä S, Farnebo F, Obara T, Isola J, Grimelius L, Farnebo LO, Sandelin K, Larsson C (2000) Patterns of chromosomal imbalances in parathyroid carcinomas. Am J Pathol 157: 579-586.
  • Laitinen S, Karhu R, Sawyers CL, Vessella RL, Visakorpi T (2002) Chromosomal aberrations in prostate cancer xenografts detected by comparative genomic hybridization. Genes Chromosomes Cancer 35: 66-73
  • Lau CC, Harris CP, Lu XY, Perlaky L, Gogineni S, Chintagumpala M, Hicks J, Johnson ME, Davino NA, Huvos AG, Meyers PA, Healy JH, Gorlick R, Rao PH (2004) Frequent amplification and rearrangement of chromosomal bands 6p12-p21 and 17p11.2 in osteosarcoma. Genes Chromosomes Cancer 39:11-21.
  • Larsen TS, Hasselbalch HC, Pallisgaard N, Kerndrup GB (2007) A der(18)t(9;18)(p13;p11) and a der(9;18)(p10;q10) in polycythemia vera associated with a hyperproliferative phenotype in transformation to postpolycythemic myelofibrosis. Cancer Genet Cytogenet 172:107-112.
  • Lee JJ, Foukakis T, Hashemi J, Grimelius L, Heldin NE, Wallin G, Rudduck C, Lui WO, Höög A, Larsson C (2007) Molecular cytogenetic profiles of novel and established human anaplastic thyroid carcinoma models. Thyroid 17:289-301
  • Lestou VS, O’Connell JX, Robichaud M, Salski C, Mathers J, Maguire J, Chudoba I, Sorensen PHB, Lam W; Horsman DE (2002) Cryptic t(X;18), ins(6;18), and SYT-SSX2 gene fusion in a case of intraneural monophasic synovial sarcoma. . Cancer Genet Cytogenet 138: 153-156.
  • Lestou VS, O’Connel JX, Ludkovski O, Gosling H, Lesack D, Horsmann DE (2002) Coamplification of 12p11 and 12q13~q22 in multiple ring chromosomes in a spindle cell sarcoma resolved by novel multicolor fluorescence in situ hybridization analysis. Cancer Genet Cytogenet 139: 44-47.
  • Lim G, Karaskova J, Beheshti B, Vukovic B, Bayani J, Selvarajah S, Watson SK, Lam WL, Zielenska M, Squire JA (2005) An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage-fusion-bridge cycle events in osteosarcoma. Genes Chr Cancer 42: 392-403.
  • Lin D, Bayani J, Wang Y, Sadar MD, Yoshimoto M, Gout PW, Squire JA, Wang Y (2010) Development of metastatic and non-metastatic tumor lines from a patient's prostate cancer specimen-identification of a small subpopulation with metastatic potential in the primary tumor. Prostate 70:1636-1644.
  • Loja T, Kuglik P, Oltova A, Smuharova P, Zitterbart K, Bajciova V, Veselska R (2007) The optimization of sample treatment for spectral karyotyping with applications for human tumour cells. Cytogenet Genome Res 116:186-193.
  • López Almaraz R, Montesdeoca Melián A, Rodríguez Luis J (2003) [The role of molecular genetics in childhood cancer] An Pediatr (Barc 59:334-344. Review
  • Lualdi E, Modena P, Debiec-Rychter M, Pedeutour F, Teixeira MR, Facchinetti F, Dagrada GP, Pilotti S, Sozzi G (2004) Molecular cytogenetic characterization of proximal-type epithelioid sarcoma. Genes Chromosomes Cancer 41:283-290.
  • Lui WO, Kytölä S, Anfalk L, Larsson C, Farnebo LO (2000) Balanced translocation (3;7)(p25;q34): another mechanism of tumorigenesis in follicular thyroid carcinoma? Cancer Genet Cytogenet 119: 109-112.
  • Lui W, Wejde J, Tani E, Brosjo O, Kytola S, Larsson C (2001) A highly aggressive primitive mesenchymal tumor with a translocation (1;19)(q12;q13.2).Cancer Genet Cytogenet 127:128-133.
  • Luk C, Tsao M-S, Bayani J, Shepherd F, Squire JA (2001) Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization. Cancer Genet Cytogenet 125: 87-99
  • Lynch HT, Sanger WG, Pirruccello S, Quinn-Laquer B, Weisenburger DD (2001) Familial multiple myeloma: a family study and review of the literature. J Natl Cancer Inst 93: 1479-1483.
  • Maire G, Brown CW, Bayani J, Pereira C, Gravel DH, Bell JC, Zielenska M, Squire JA (2008) Complex rearrangement of chromosomes 19, 21, and 22 in Ewing sarcoma involving a novel reciprocal inversion-insertion mechanism of EWS-ERG fusion gene formation: a case analysis and literature review. Cancer Genet Cytogenet 181:81-92
  • Manor E, Kapelushnik J, Joshua BZ, Bodner L (2012) Metastatic neuroblastoma of the mandible: a cytogenetic and molecular genetic study. Eur Arch Otorhinolaryngol 269:1967-1971.
  • Mathew S, Dalton J, Riedley S, Spunt SL, Hill DA (2002) Complex t(X;18)(p11.2;q11.2) with a pericentric inversion of the X chromosome in an adolescent boy with synovial sarcoma. Cancer Genet Cytogenet 132:136-140.
  • Micci F, Teixeira MR, Bjerkehagen B, Heim S (2002) Characterization of supernumerary rings and giant marker chromosomes in well-differentiated lipomatous tumors by a combination of G-banding, CGH, M-FISH and chromosome- and locus-specific FISH. Cytogenet Genome Res 97: 13-19.
  • Micci F, Teixeira MR, Scheistroen M, Abeler VM, Heim S (2003) Cytogenetic characterization of tumors of the vulva and vagina. Genes Chromosomes Cancer 38:137-148.
  • Mocker K, Holland H, Ahnert P, Schober R, Bauer M, Kirsten H, Koschny R, Meixensberger J, Krupp W (2011) Multiple meningioma with different grades of malignancy: case report with genetic analysis applying single-nucleotide polymorphism array and classical cytogenetics. Pathol Res Pract 207:67-72.
  • Mrozek K, Iliszko M, Rys J, Babinska M, Niezabitowski A, Bloomfield CD, Limon J (2001) Spectral karyotyping reveals 17;22 fusions in a cytogenetically atypical dermatofibrosarcoma protuberans with a large marker chromosome as a sole abnormality. Genes Chr Cancer 31: 182-186.
  • Nandula SV, Borczuk AC, Murty VV (2004) Unbalanced t(2;19) and t(2;16) in a neurofibroma. Cancer Genet Cytogenet 152: 169-171.
  • Naus NC, van Drunen E, de Klein A, Luyten GP, Paridaens DA, Alers JC, Ksander BR, Beverloo HB, Slater RM (2001) Characterization of complex chromosomal abnormalities in uveal melanoma by fluorescence in situ hybridization, spectral karyotyping, and comparative genomic hybridization. Genes Chromosomes Cancer 30: 267-273.
  • Negahban S, Ahmadi N, Oryan A, Khojasteh HN, Aledavood A, Soleimanpour H, Mohammadianpanah M, Oschlies I, Gesk S, Siebert R, Daneshbod K, Daneshbod Y (2010) Primary bilateral Burkitt lymphoma of the lactating breast: a case report and review of the literature. Mol Diagn Ther 14:243-250.
  • Nicholson JM, Duesberg P (2009) On the karyotypic origin and evolution of cancer cells. Cancer Genet Cytogenet 194:96-110.
  • Nishio J, Iwasaki H, Althof PA, Naumann S, Ishiguro M, Haraoka S, Iwashita A, Iwasaki A, Kaku Y, Kaneko Y, Kikuchi M, Bridge JA (2005) Identification of a ring chromosome with spectral karyotyping in a pleural synovial sarcoma. Cancer Genet Cytogenet 160: 174-178.
  • Ogose A, Kawashima H, Umezu H, Hotta T, Gu W, Yamagiwa H, Ito T, Tohyama T, Nishijima H, Endo N (2004) Sclerosing epithelioid fibrosarcoma with der(10)t(10;17)(p11;q11). Cancer Genet Cytogenet 152: 136-140.
  • O'Malley DP, Opheim KE, Barry TS, Chapman DB, Emond MJ, Conrad EU, Norwood TH (2001) Chromosomal changes in a dedifferentiated chondrosarcoma: a case report and review of the literature. Cancer Genet Cytogenet 124:105-111.
  • Pandita A, Zielenska M, Thorner P, Bayani J, Godbout R, Greenberg M, Squire JA (1999) Application of comparative genomic hybridization, spectral karyotyping, and microarray analysis in the identification of subtype-specific patterns of genomic changes in rhabdomyosarcoma. Neoplasia 1: 262-275.
  • Parham DM, Bridge JA, Lukacs JL, Ding Y, Tryka AF, Sawyer JR (2004) Cytogenetic distinction among benign fibro-osseous lesions of bone in children and adolescents: value of karyotypic findings in differential diagnosis. Pediatr Dev Pathol 7:148-158
  • Perissel B, Coupier I, De Latour M, Cardot N, Penault-Llorca F, Jaffray J, Giollant M, Fonck Y, Malet P (2000) Structural and numerical aberrations of chromosome 22 in a case of follicular variant of papillary thyroid carcinoma revealed by conventional and molecular cytogenetics. Cancer Genet Cytogenet 121: 33-37.
  • Persson F, Andrén Y, Winnes M, Wedell B, Nordkvist A, Gudnadottir G, Dahlenfors R, Sjögren H, Mark J, Stenman G (2009) High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2. Genes Chromosomes Cancer 48:69-82.
  • Phillips JL, Ghadimi BM, Wangsa D, Padilla-Nash H, Worrell R, Hewitt S, Walther M, Linehan WM, Klausner RD, Ried T (2001)Molecular cytogenetic characterization of early and late renal cell carcinomas in Von Hippel-Lindau disease. Genes Chr Cancer 31: 1-9.
  • Popp S, Waltering S, Holtgreve-Grez H, Jauch A, Proby C, Leigh IM, Boukamp P (2000) Genetic characterization of a human skin carcinoma progression model: from primary tumor to metastasis. J Invest Dermatol 115:1095-1103.
  • Prochazkova M, Chevret E, Beylot-Barry M, Vergier B, Sobotka J, Merlio JP (2005) Large cell transformation of mycosis fungoides: tetraploidization within skin tumor large cells. Cancer Genet Cytogenet 163:1-6.
  • Rao PH, Harris CP, Yan Lu X, Li XN, Mok SC, Lau CC (2002) Multicolor spectral karyotyping of serous ovarian adenocarcinoma. Genes Chromosomes Cancer 33: 123-132.
  • Reshmi SC, Saunders WS, Kudla DM, Ragin CR, Gollin SM (2004) Chromosomal instability and marker chromosome evolution in oral squamous cell carcinoma. Genes Chromosomes Cancer 41: 38-46.
  • Rodon N, Sole F, Espinet B, Salido M, Zamora L, Cigudosa JC, Woessner S, Florensa L (2002) A new case of acute nonlymphocytic leukemia (French-American-British subtype M1) with double minutes and c-MYC amplification. Cancer Genet Cytogenet 132: 161-164.
  • Rogatto SR, Rainho CA, Zhang ZM, Figueiredo F, Barbieri-Neto J, Georgetto SM, Squire JA (1999) Hemangioendothelioma of bone in a patient with a constitutional supernumerary marker. Cancer Genet Cytogenet 110: 23-27.
  • Rondón-Lagos M, Verdun Di Cantogno L, Rangel N, Mele T, Ramírez-Clavijo SR, Scagliotti G, Marchiò C, Sapino A (2014) Unraveling the chromosome 17 patterns of FISH in interphase nuclei: an in-depth analysis of the HER2 amplicon and chromosome 17 centromere by karyotyping, FISH and M-FISH in breast cancer cells. BMC Cancer 14: 922.
  • Planck M, Halvarsson B, Palsson E, Hallen M, Ekelund M, Palsson B, Baldetorp B, Nilbert M (2002) Cytogenetic aberrations and heterogeneity of mutations in repeat-containing genes in a colon carcinoma from a patient with hereditary nonpolyposis colorectal cancer. Cancer Genet Cytogenet 134: 46-54.
  • Safar A, Nelson M, Neff JR, Maale GE, Bayani J, Squire J, Bridge JA (2000) Recurrent anomalies of 6q25 in chondromyxoid fibroma. Hum Pathol 31: 306-311.
  • Salaverria I, Espinet B, Carrió A, Costa D, Astier L, Slotta-Huspenina J, Quintanilla-Martinez L, Fend F, Solé F, Colomer D, Serrano S, Miró R, Beà S, Campo E (2008) Multiple recurrent chromosomal breakpoints in mantle cell lymphoma revealed by a combination of molecular cytogenetic techniques. Genes Chromosomes Cancer 47:1086-1097.
  • Sandberg AA, Bridge JA (2003) Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: chondrosarcoma and other cartilaginous neoplasms. Cancer Genet Cytogenet 143: 1-31.
  • Sawyer JR, Husain M, Lukacs JL, Stangeby C, Binz RL, Al-Mefty O (2003) Telomeric fusion as a mechanism for the loss of 1p in meningioma. Cancer Genet Cytogenet 145: 38-48.
  • Schuler N, Palm J, Schmitz S, Lorat Y, Rübe CE (2017) Increasing genomic instability during cancer therapy in a patient with Li-Fraumeni syndrome. Clin Transl Radiat Oncol 2;7:71-78.
  • Selvarajah S, Yoshimoto M, Prasad M, Shago M, Squire JA, Zielenska M, Somers GR (2007) Characterization of trisomy 8 in pediatric undifferentiated sarcomas using advanced molecular cytogenetic techniques. Cancer Genet Cytogenet 174:35-41.
  • Shaughnessy Jr. J, Tian E, Sawyer J, Bumm K, Landes R, Badros A, Morris C, Tricot G, Epstein J, Barlogie B (2000) High incidence of chromosome 13 deletion in multiple myeloma detected by multiprobe interphase FISH. Blood 96: 1505-1511.
  • Shen H, Zhu Y, Wu YJ, Qiu HR, Shu YQ (2008) Genomic alterations in lung adenocarcinomas detected by multicolor fluorescence in situ hybridization and comparative genomic hybridization. Cancer Genet Cytogenet 181:100-107
  • Shing DC, Morley-Jaboc CA, Roberts I, Nacheva E, Coleman N (2002) Ewing's tumour: novel recurrent chromosomal abnormalities demonstrated by molecular cytogenetic analysis of seven cell lines and one primary culture. Cytogenet Genome Res 97: 20-27.
  • Simons J, Teshima I, Zielenska M, Edwards V, Taylor G, Squire J, Thorner P (1999) Analysis of chromosome 22q as an aid to the diagnosis of rhabdoid tumor: a case report. Am J Surg Pathol 23: 982-988.
  • Sirivatanauksorn V, Sirivatanauksorn Y, Gorman PA, Davidson JM, Sheer D, Moore PS, Scarpa A, Edwards PA, Lemoine NR (2001) Non-random chromosomal rearrangements in pancreatic cancer cell lines identified by spectral karyotyping. Int J Cancer 91:350-358.
  • Sirvent N, Hawkins AL, Moeglin D, Coindre JM, Kurzenne JY, Michiels JF, Barcelo G, Turc-Carel C, Griffin CA, Pedeutour F (2001) ALK probe rearrangement in a t(2;11;2)(p23;p15;q31) translocation found in a prenatal myofibroblastic fibrous lesion: Toward a molecular definition of an inflammatory myofibroblastic tumor family? Genes Chr Cancer 31: 85-90.
  • Sisley K, Tattersall N, Dyson M, Smith K, Mudhar HS, Rennie IG (2006) Multiplex fluorescence in situ hybridization identifies novel rearrangements of chromosomes 6, 15, and 18 in primary uveal melanoma. Exp Eye Res 83:554-559
  • Sjögren H, Nilsson O, Behrendt M, Kolby L, Jacobsen Levin AM, Ahlman H, Stenman G (2000) Multicolor spectral karyotype analysis of a transplantable human ileal carcinoid. Int J Mol Med 6: 629-633.
  • Sjögren H, Wedell B, Meis-Kindblom JM, Kindblom LG, Stenman G (2000) Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21). Cancer Res. 60:6832-6835. Erratum in: Cancer Res 2001 Mar 1;61(5):2339. Kindblom JM [corrected to Meis-Kindblom JM].
  • Sjögren H, Orndal C, Tingby O, Meis-Kindblom JM, Kindblom LG, Stenman G (2004) Cytogenetic and spectral karyotype analyses of benign and malignant cartilage tumours. Int J Oncol 24:1385-1391
  • Speicher MR, Petersen S, Uhrig S, Jentsch I, Fauth C, Eils R, Petersen I (2000) Analysis of chromosomal alterations in non-small cell lung cancer by multiplex-FISH, comparative genomic hybridization, and multicolor bar coding. Lab Invest 80: 1031-1041.
  • Squire JA, Arab S, Marrano P, Bayani J, Karaskova J, Taylor M, Becker L, Rutka J, Zielenska M (2001) Molecular cytogenetic analysis of glial tumors using spectral karyotyping and comparative genomic hybridization.Mol Diagn 6: 93-108.
  • Stamouli MI, Ferti AD, Panani AD, Raftakis J, Consoli C, Raptis SA, Young BD (2002) Application of multiplex fluorescence in situ hybridization in the cytogenetic analysis of primary gastric carcinoma. Cancer Genet Cytogenet 135: 23-27.
  • Stamouli MI, Panani AD, Ferti AD, Petraki C, Oliver RT, Raptis SA, Young BD (2004) Detection of genetic alterations in primary bladder carcinoma with dual-color and multiplex fluorescence in situ hybridization. Cancer Genet Cytogenet. 149: 107-113.
  • Stark B, Jeison M, Bar-Am I, Glaser-Gabay L, Mardoukh J, Luria D, Feinmesser M, Goshen Y, Stein J, Abramov A, Zaizov R, Yaniv I (2002) Distinct cytogenetic pathways of advanced-stage neuroblastoma tumors, detected by spectral karyotyping. Genes Chromosomes Cancer 34: 313-324.
  • Stark B, Jeison M, Glaser-Gabay L, Bar-Am I, Mardoukh J, Ash S, Atias D, Stein J, Zaizov R, Yaniv I (2003) der(11)t(11;17): a distinct cytogenetic pathway of advanced stage neuroblastoma (NBL) - detected by spectral karyotyping (SKY). Cancer Lett 197:75-79. Review.
  • Stejskalová E, Malis J, Snajdauf J, Pýcha K, Urbánková H, Bajciová V, Starý J, Kodet R, Jarosová M (2009) Cytogenetic and array comparative genomic hybridization analysis of a series of hepatoblastomas. Cancer Genet Cytogenet 194:82-87.
  • Storlazzi CT, Mertens F, Domanski H, Fletcher CD, Wiegant J, Mandahl N (2003) Ring chromosomes and low-grade gene amplification in an atypical lipomatous tumor with minimal nuclear atypia. Int J Oncol 23: 67-71.
  • Storlazzi CT, Mertens F, Mandahl N, Gisselsson D, Isaksson M, Gustafson P, Domanski HA, Panagopoulos I (2003) A novel fusion gene, SS18L1/SSX1, in synovial sarcoma.Genes Chromosomes Cancer 37: 195-200.
  • Struski S, Doco-Fenzy M, Koehler M, Chudoba I, Levy F, Masson L, Michel N, Ulrich E, Gruson N, Benard J, Potron G, Cornillet-Lefebvre P (2003) Cytogenetic evolution of human ovarian cell lines associated with chemoresistance and loss of tumorigenicity. Anal Cell Pathol 25:115-122.
  • Sy SM, Fan B, Lee TW, Mok TS, Pang E, Yim A, Wong N (2004) Spectral karyotyping indicates complex rearrangements in lung adenocarcinoma of nonsmokers. Cancer Genet Cytogenet 153:57-59
  • Szuhai K, Knijnenburg J, Ijszenga M, Tanke HJ, Baatenburg de Jong RJ, Bas Douwes Dekker P, Rosenberg C, Hogendoorn PC (2004) Multicolor fluorescence in situ hybridization analysis of a synovial sarcoma of the larynx with a t(X;18)(p11.2;q11.2) and trisomies 2 and 8. Cancer Genet Cytogenet 153(1):48-52.
  • Szuhai K, IJszenga M, Tanke HJ, Taminiau AH, de Schepper A, van Duinen SG, Rosenberg C, Hogendoorn PC (2007) Detection and molecular cytogenetic characterization of a novel ring chromosome in a histological variant of Ewing sarcoma. Cancer Genet Cytogenet 172:12-22.
  • Szuhai K, Ijszenga M, Knijnenburg J, Dijkstra S, de Schepper A, Tanke HJ, Hogendoorn PC (2007) Does parosteal liposarcoma differ from other atypical lipomatous tumors/well-differentiated liposarcomas? A molecular cytogenetic study using combined multicolor COBRA-FISH karyotyping and array-based comparative genomic hybridization. Cancer Genet Cytogenet 176:115-120
  • Tassano E, Nozza P, Tavella E, Garaventa A, Panarello C, Morerio C (2010) Cytogenetic characterization of a fibrous hamartoma of infancy with complex translocations. Cancer Genet Cytogenet 201:66-69.
  • Trakhtenbrot L, Cohen N, Rosner E, Gipsh N, Brok-Simoni F, Mandel M, Amariglio N, Rechavi G (1999) Coexistence of several unbalanced translocations in a case of neuroblastoma: the contribution of multicolor spectral karyotyping. Cancer Genet Cytogenet 112: 119-123.
  • Treszl A, Ladanyi A, Rakosy Z, Buczko Z, Adany R, Balazs M (2006) Molecular cytogenetic characterization of a novel cell line established from a superficial spreading melanoma. Front Biosci 11:1844-1853
  • Tsarouha H, Kyriazoglou AI, Ribeiro FR, Teixeira MR, Agnantis N, Pandis N (2006) Chromosome analysis and molecular cytogenetic investigations of an epithelioid hemangioendothelioma. Cancer Genet Cytogenet 169:164-168.
  • Van Gele M, Leonard JH, Van Roy N, Van Limbergen H, Van Belle S, Cocquyt V, Salwen H, De Paepe A, Speleman F (2002) Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma. Int J Cancer 101: 137-145.
  • Varella-Garcia M, Chen L, Powell RL, Hirsch FR, Kennedy TC, Keith R, Miller YE, Mitchell JD, Franklin WA (2007) Spectral karyotyping detects chromosome damage in bronchial cells of smokers and patients with cancer. Am J Respir Crit Care Med 176:505-512
  • Vural M, Arslantas A, Ciftci E, Artan S, Adapinar B (2010) Multiple intradural-extramedullary ependymomas: proven dissemination by genetic analysis. J Neurosurg Spine 12:467-473.
  • Wang R, Lu YJ, Fisher C, Bridge JA, Shipley J (2001) Characterization of chromosome aberrations associated with soft-tissue leiomyosarcomas by twenty-four-color karyotyping and comparative genomic hybridization analysis. Genes Chr Cancer 31: 54-64.
  • Watson MB, Bahia H, Ashman JN, Berrieman HK, Drew P, Lind MJ, Greenman J, Cawkwell L (2004) Chromosomal alterations in breast cancer revealed by multicolour fluorescence in situ hybridization. Int J Oncol 25:277-283.
  • Watson SK, deLeeuw RJ, Horsman DE, Squire JA, Lam WL (2007) Cytogenetically balanced translocations are associated with focal copy number alterations. Hum Genet 120:795-805
  • Weier HU, Ito Y, Kwan J, Smida J, Weier JF, Hieber L, Lu CM, Lehmann L, Wang M, Kassabian HJ, Zeng H, O'Brien B (2011) Delineating Chromosomal Breakpoints in Radiation-Induced Papillary Thyroid Cancer.Genes (Basel). 2:397-419.
  • Weng WH, Wejde J, Ahlen J, Pang ST, Lui WO, Larsson C (2004) Characterization of large chromosome markers in a malignant fibrous histiocytoma by spectral karyotyping, comparative genomic hybridization (CGH), and array CGH. Cancer Genet Cytogenet. 150: 27-32.
  • Williams SV, Platt FM, Hurst CD, Aveyard JS, Taylor CF, Pole JC, Garcia MJ, Knowles MA (2010) High-resolution analysis of genomic alteration on chromosome arm 8p in urothelial carcinoma. Genes Chromosomes Cancer 49:642-659.
  • Wolf M, Mousses S, Hautaniemi S, Karhu R, Huusko P, Allinen M, Elkahloun A, Monni O, Chen Y, Kallioniemi A, et al. (2004) High-resolution analysis of gene copy number alterations in human prostate cancer using CGH on cDNA microarrays: impact of copy number on gene expression. Neoplasia 6(3):240-247
  • Yamashita Y, Nishida K, Okuda T, Nomura K, Matsumoto Y, Mitsufuji S, Horiike S, Hata H, Sakakura C, Hagiwara A, Yamagishi H, Taniwaki M (2005) Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping. World J Gastroenterol 11:5129-5135.
  • Yang ZM, Han XP, Wu SF, Yin YF, Wang K, Gao J, Liang ZY, Zeng X (2010) [Analysis of chromosomal abnormalities in pancreatic cancer by spectral karyotyping]. Zhonghua Bing Li Xue Za Zhi 39:767-771. Chinese.
  • Yao HQ, He S, Wu YP, Wang XC, Han YL, Xu X, Cai Y, Wang GQ, Wang MR (2008) [Application of Multicolor Fluorescence In situ Hybridization to Early Diagnosis of Esophageal Squamous Cell Carcinoma.] Ai Zheng 27:1137-1143. Chinese.
  • Yeh YA, Rao PH, Cigna CT, Middlesworth W, Lefkowitch JH, Murty VV (2000) Trisomy 1q, 2, and 20 in a case of hepatoblastoma: possible significance of 2q35-q37 and 1q12-q21 rearrangements. Cancer Genet Cytogenet 123: 140-143.
  • Yoshimoto M, Graham C, Chilton-MacNeill S, Lee E, Shago M, Squire J, Zielenska M, Somers GR (2009) Detailed cytogenetic and array analysis of pediatric primitive sarcomas reveals a recurrent CIC-DUX4 fusion gene event. Cancer Genet Cytogenet 195:1-11.
  • Yuan H, Krawczyk E, Blancato J, Albanese C, Zhou D, Wang N, Paul S, Alkhilaiwi F, Palechor-Ceron N, Dakic A, Fang S, Choudhary S, Hou TW, Zheng YL, Haddad BR, Usuda Y, Hartmann D, Symer D, Gillison M, Agarwal S, Wangsa D, Ried T, Liu X, Schlegel R (2017) HPV positive neuroendocrine cervical cancer cells are dependent on Myc but not E6/E7 viral oncogenes. Sci Rep 7: 45617.
  • Zang KD (2001) Meningioma: a cytogenetic model of a complex benign human tumor, including data on 394 karyotyped cases. Cytogenet Cell Genet 93: 207-220.
  • Zattara-Cannoni H, Roll P, Figarella-Branger D, Lena G, Dufour H, Grisoli F, Vagner-Capodano A (2001) Cytogenetic study of six cases of radiation-induced meningiomas.Cancer Genet Cytogenet 126: 81-84.
  • Zhao L, Hayes K, Van Fleet T, Glassmann A (2003) Detection of a novel reciprocal t(16;22)(q11.2;q12) in Ewing sarcoma. Cancer Genet Cytogenet 140: 55-57.
  • Zhao H, Kim Y, Wang P, Lapointe J, Tibshirani R, Pollack JR, Brooks JD (2005) Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines. Prostate 63(2):187-197
  • Zielenska M, Bayani J, Pandita A, Toledo S, Marrano P, Andrade J, Petrilli A, Thorner P, Sorensen P, Squire JA (2001) Comparative genomic hybridization analysis identifies gains of 1p35 approximately p36 and chromosome 19 in osteosarcoma.Cancer Genet Cytogenet 130:14-21.
  • Zielenska M, Zhang ZM, Ng K, Marrano P, Bayani J, Ramirez OC, Sorensen P, Thorner P, Greenberg M, Squire JA (2001) Acquisition of secondary structural chromosomal changes in pediatric ewing sarcoma is a probable prognostic factor for tumor response and clinical outcome.Cancer 91: 2156-2164.
  • Zuber MA, Krupp W, Holland H, Froster UG (2002) Characterization of chromosomal aberrations in a case of glioblastoma multiforme combining cytogenetic and molecular cytogenetic techniques. Cancer Genet Cytogenet 138. 111-115.


Cell lines

see also SKY Karyotypes and FISH analysis of Epithelial Cancer Cell Lines at
http://www.path.cam.ac.uk/~pawefish/

see also SKY/M-FISH and CGH Database
The data in this study were submitted to dbVar by the SKY-CGH database upon its retirement in September, 2016. They consist of detailed cytogenetic analyses of tumor-vs.-normal cancer samples from a wide variety of cases. The data are currently being curated for display in dbVar; in the meantime, they can be downloaded by following this FTP link.


  • Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D, Bodmer WF, Arends MJ, Wyllie AH, Edwards PA (2001) Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement. Proc Natl Acad Sci U S A 98: 2538-2543.
  • Abdel-Rahman WM, Lohi H, Knuutila S, Peltomäki P (2005) Restoring mismatch repair does not stop the formation of reciprocal translocations in the colon cancer cell line HCA7 but further destabilizes chromosome number. Oncogene 24:706-713
  • AbouAlaiwi WA, Rodriguez I, Nauli SM (2012) Spectral karyotyping to study chromosome abnormalities in humans and mice with polycystic kidney disease. J Vis Exp 2012 Feb 3;(60). pii: 3887. doi: 10.3791/3887.
  • Adam P, Steinlein C, Schmid M, Haralambieva E, Stocklein H, Leich E, Rosenwald A, Muller-Hermelink HK, Ott G (2006) Characterization of chromosomal aberrations in diffuse large B-cell lymphoma (DLBL) by G-banding and spectral karyotyping (SKY). Cytogenet Genome Res 114:274-278.
  • Adelaide J, Huang HE, Murati A, Alsop AE, Orsetti B, Mozziconacci MJ, Popovici C, Ginestier C, Letessier A, Basset C, Courtay-Cahen C, Jacquemier J, Theillet C, Birnbaum D, Edwards PA, Chaffanet M (2003) A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene. Genes Chromosomes Cancer 37: 333-345.
  • Aldosari N, Wiltshire RN, Dutra A, Schrock E, McLendon RE, Friedman HS, Bigner DD, Bigner SH (2002) Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft. Neuro-oncol 4: 75-85.
  • Allen RJ, Smith SD, Moldwin RL, Lu MM, Giordano L, Vignon C, Suto Y, Harden A, Tomek R, Veldman T, Ried T, Larson RA, Le Beau MM, Rowley JD, Zeleznik-Le N (1998) Establishment and characterization of a megakaryoblast cell line with amplification of MLL. Leukemia 12: 1119-1127.
  • Arenz A, Patze J, Kornmann E, Wilhelm J, Ziemann F, Wagner S, Wittig A, Schoetz U, Engenhart-Cabillic R, Dikomey E, Fritz B (2019) HPV-negative and HPV-positive HNSCC cell lines show similar numerical but different structural chromosomal aberrations. Head Neck 41:3869-3879.
  • Ariyama Y, Sakabe T, Shinomiya T, Mori T, Fukuda Y, Inazawa J (1998) Identification of amplified DNA sequences on double minute chromosomes in a leukemic cell line KY821 by means of spectral karyotyping and comparative genomic hybridization. J Hum Genet 43: 187-190.
  • Astbury C, Jackson-Cook CK, Culp SH, Paisley TE, Ware JL (2001) Suppression of tumorigenicity in the human prostate cancer cell line M12 via microcell-mediated restoration of chromosome 19.Genes Chr Cancer 31: 143-155.
  • Aurich-Costa J, Vannier A, Gregoire E, Nowak F, Cherif D (2001) IPM-FISH, a new M-FISH approach using IRS-PCR painting probes: application to the analysis of seven human prostate cell lines. Genes Chromosomes Cancer 30: 143-160.
  • Backsch C, Pauly B, Liesenfeld M, Scheungraber C, Gajda M, Mrasek K, Liehr T, Clad A, Schrock E, Runnebaum IB, Dürst M (2011) Two novel unbalanced whole arm translocations are frequently detected in cervical squamous cell carcinoma. Cancer Genet 204: 646-653.
  • Bahia H, Ashman JN, Cawkwell L, Lind M, Monson JR, Drew PJ, Greenman J (2002) Karyotypic variation between independently cultured strains of the cell line MCF-7 identified by multicolour fluorescence in situ hybridization. Int J Oncol 20: 489-494.
  • Barenboim-Stapleton L, Yang X, Tsokos M, Wigginton JM, Padilla-Nash H, Ried T, Thiele CJ (2005) Pediatric pancreatoblastoma: histopathologic and cytogenetic characterization of tumor and derived cell line. Cancer Genet Cytogenet 157:109-117.
  • Bayani J, Zielenska M, Marrano P, Kwan Ng Y, Taylor MD, Jay V, Rutka JT, Squire JA (2000) Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping. J Neurosurg 93: 437-448.
  • Begley L, Keeney D, Beheshti B, Squire JA, Kant R, Chaib H, MacDonald JW, Rhim J, Macoska JA (2006) Concordant copy number and transcriptional activity of genes mapping to derivative chromosomes 8 during cellular immortalization in vitro. Genes Chromosomes Cancer 45:136-146.
  • Beh TT, MacKinnon RN, Kalitsis P (2016) Active centromere and chromosome identification in fixed cell lines. Mol Cytogenet 9: 28.
  • Beheshti B, Karaskova J, Park PC, Squire JA, Beatty BG (2000) Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer cell lines by sequential Giemsa-banding and spectral karyotyping. Molecular Diagnosis 5: 23-32.
  • Beheshti B, Park PC, Sweet JM, Trachtenberg J, Jewett MA, Squire JA (2001) Evidence of chromosomal instability in prostate cancer determined by spectral karyotyping (sky) and interphase fish analysis. Neoplasia 3: 62-69.
  • Berglund M, Flodal E, Gullander J, Lui W-O, Larsson C, Lagercrantz S, Enbald G (2003) Molecular characterization of four commonly used cell lines derived from Hodgkin lymphoma. Cancer Genet Cytogenet 141: 43-48.
  • Betts DR, Cohen N, Leibundgut KE, Kühne T, Caflisch U, Greiner J, Traktenbrot L, Niggli FK (2005) Characterization of karyotypic events and evolution in neuroblastoma.Pediatr Blood Cancer 44:147-157
  • Bible KC, Boerner SA, Kirkland K , Anderl KL, Bartelt JR D, Svingen PA, Kottke TJ, Lee YK, Eckdahl S, Stalboerger PG, Jenkins RB, Kaufmann SH (2000)Characterization of an ovarian carcinoma cell line resistant to cisplatin and flavopiridol. Clinical Cancer Res 6:661-670.
  • Bigner SH, Schröck E (1997) Molecular cytogenetics of brain tumors. J Neuropathol Exp Neurol 56: 1173-1181.
  • Binz RL, Tian E, Sadhukhan R, Zhou D, Hauer-Jensen M, Pathak R (2019) Identification of novel breakpoints for locus- and region-specific translocations in 293 cells by molecular cytogenetics before and after irradiation. Sci Rep 9:10554.
  • Brassesco MS, Cortez MA, Valera ET, Engel EE, Nogueira-Barbosa MH, Becker AP, Scrideli CA, Tone LG (2010) Cryptic SYT/SXX1 fusion gene in high-grade biphasic synovial sarcoma with unique complex rearrangement and extensive BCL2 overexpression. Cancer Genet Cytogenet 196:189-193.
  • Bridge RS Jr, Bridge JA, Neff JR, Naumann S, Althof P, Bruch LA (2004) Recurrent chromosomal imbalances and structurally abnormal breakpoints within complex karyotypes of malignant peripheral nerve sheath tumour and malignant triton tumour: a cytogenetic and molecular cytogenetic study. J Clin Pathol 57:1172-1178
  • Brothman AR, Maxwell TM, Cui J, Deubler DA, Zhu XL (1999) Chromosomal clues to the development of prostate tumors. Prostate 38: 303-312.
  • Brothman AR, Xhu XL, Maxwell T, Cui J, Deubler DA (1999) Advances in the cytogenetics of prostate cancer. J. Assoc. Genetic Technologists 25: 1-6.
  • Bylund L, Kytola S, Lui WO, Larsson C, Weber G (2004) Analysis of the cytogenetic stability of the human embryonal kidney cell line 293 by cytogenetic and STR profiling approaches. Cytogenet Genome Res 106:28-32.
  • Camps J, Morales C, Prat E, Ribas M, Capellà G, Egozcue J, Peinado MA, Miró R (2004) Genetic evolution in colon cancer KM12 cells and metastatic derivates. Int J Cancer 110:869-874.
  • Chaganti SR, Chen W, Parsa N, Offit K, Louie DC, Dalla-Favera R, Chaganti RS (1998) Involvement of BCL6 in chromosomal aberrations affecting band 3q27 in B-cell non-Hodgkin lymphoma. Genes Chromosomes Cancer 23: 323-327.
  • Chan KY, Wong N, Lai PB, Squire JA, Macgregor PF, Beheshti B, Albert M, To KF, Johnson PJ (2005) Transcriptional profiling on chromosome 19p indicated frequent downregulation of ACP5 expression in hepatocellular carcinoma. Int J Cancer 114:902-908
  • Chen IM, Whalen M, Bankhurst A, Sever CE, Doshi R, Hardekopf D, Montgomery K, Willman CL (2004) A new human natural killer leukemia cell line, IMC-1. A complex chromosomal rearrangement defined by spectral karyotyping: functional and cytogenetic characterization. Leuk Res 28:275-284
  • Chen SN, Xue YQ, Zhang XG, Wu YF, Pan JL, Wang Y, Cen JN (2005) [Establishment and characterization of a human acute monocytic leukemic cell line, SHI-1, carrying t(6;11)(q27;23) and p53 gene alteration] Zhonghua Xue Ye Xue Za Zhi 26:94-99. Chinese
  • Chen F, Clark DP, Hawkins AL, Morsberger LA, Griffin CA (2007) A break-apart fluorescence in situ hybridization assay for detecting RET translocations in papillary thyroid carcinoma. Cancer Genet Cytogenet 178:128-134.
  • Chun YH, Kil JI, Suh YS, Kim SH, Kim H, Park SH (2000) Characterization of chromosomal aberrations in human gastric carcinoma cell lines using chromosome painting. Cancer Genet Cytogenet 119:18-25.
  • Cohen N, Betts DR, Rechavi G, Amariglio N, Trakhtenbrot L (2003) Clonal expansion and not cell interconversion is the basis for the neuroblast and nonneuronal types of the SK-N-SH neuroblastoma cell line. Cancer Genet Cytogenet 143: 80-84.
  • Cohen N, Betts DR, Tavori U, Toren A, Ram T, Constantini S, Grotzer MA, Amariglio N, Rechavi G, Trakhenbrot L (2004) Karyotypic evolution pathsways in medulloblastoma/primitive neuroectodermal tumor determined with a combination of spectral karyotyping, G-banding, and fluorescence in situ hybridization. Cancer Genet Cytogenet 149: 44-52.
  • Cottage A, Dowen S, Roberts I, Pett M, Coleman N, Stanley M (2001) Early genetic events in HPV immortalised keratinocytes. Genes Chromosomes Cancer 30: 72-79.
  • Cottier M, Tchirkov A, Perissel B, Giollant M, Campos L, Vago P (2004) Cytogenetic characterization of seven human cancer cell lines by combining G- and R-banding, M-FISH, CGH and chromosome- and locus-specific FISH. Int J Mol Med 14:483-495
  • Cowell JK, LaDuca J, Rossi MR, Burkhardt T, Nowak NJ, Matsui S (2005) Molecular characterization of the t(3;9) associated with immortalization in the MCF10A cell line. Cancer Genet Cytogenet 163:23-29.
  • Davidson JM, Gorringe KL, Chin SF, Orsetti B, Besret C, Courtay-Cahen C, Roberts I, Theillet C, Caldas C, Edwards PA (2000) Molecular cytogenetic analysis of breast cancer cell lines. Br J Cancer 83:1309-1317.
  • da Silva FE, Cordeiro AB, Nagamachi CY, Pieczarka JC, Rens W, Weise A, Liehr T, Mkrtchyan H, Anselmo NP, de Oliveira EH (2010) A case of aggressive medulloblastoma with multiple recurrent chromosomal alterations. Cancer Genet Cytogenet 196:198-200.
  • de Jong J, Stoop H, Gillis AJ, Hersmus R, van Gurp RJ, van de Geijn GJ, van Drunen E, Beverloo HB, Schneider DT, Sherlock JK, Baeten J, Kitazawa S, van Zoelen EJ, van Roozendaal K, Oosterhuis JW, Looijenga LH (2008) Further characterization of the first seminoma cell line TCam-2. Genes Chromosomes Cancer 47:185-196.
  • Dennis TR, Stock AD (1999) A molecular cytogenetic study of chromosome 3 rearrangements in small cell lung cancer: consistent involvement of chromosome band 3q13.2. Cancer Genet Cytogenet 113: 134-140.
  • Denyssevych T, Lestou VS, Knesevich S, Robichaud M, Salski C, Tan R, Gascoyne RD, Horsman DE, Mayer LD (2002) Establishment and comprehensive analysis of a new human transformed follicular lymphoma B cell line, Tat-1. Leukemia 16: 276-283.
  • Desmaze C, Pirzio LM, Blaise R, Mondello C, Giulotto E, Murnane JP, Sabatier L (2004) Interstitial telomeric repeats are not preferentially involved in radiation-induced chromosome aberrations in human cells. Cytogenet Genome Res 104: 123-130.
  • Dowen SE, Neutze DM, Pett MR, Cottage A, Stern P, Coleman N, Stanley MA (2003) Amplification of chromosome 5p correlates with increased expression of Skp2 in HPV-immortalized keratinocytes. Oncogene 22:2531-2540
  • Elghezal H, Le Guyader G, Radford-Weiss I, Perot C, Van Den Akker J, Eydoux P, Vekemans M, Romana SP (2001) Reassessment of childhood B-lineage lymphoblastic leukemia karyotypes using spectral analysis. Genes Chr Cancer 30: 383-392.
  • Erdreich-Epstein A, Ganguly AK, Shi XH, Zimonjic DB, Shackleford GM (2006) Androgen inducibility of Fgf8 in Shionogi carcinoma 115 cells correlates with an adjacent t(5;19) translocation. Genes Chromosomes Cancer 45:169-181.
  • Fadl-Elmula I, Kytola S, Pan Y, Lui WO, Derienzo G, Forsberg L, Mandahl N, Gorunova L, Bergerheim US, Heim S, Larsson C (2001) Characterization of chromosomal abnormalities in uroepithelial carcinomas by G-banding, spectral karyotyping and FISH analysis. Int J Cancer 92: 824-831.
  • Fang Y, Elahi A, Denley RC, Rao PH, Brennan MF, Jhanwar SC (2009) Molecular characterization of permanent cell lines from primary, metastatic and recurrent malignant peripheral nerve sheath tumors (MPNST) with underlying neurofibromatosis-1. Anticancer Res 29:1255-1262.
  • Fauth C, O'Hare MJ, Lederer G, Jat PS, Speicher MR (2004) Order of genetic events is critical determinant of aberrations in chromosome count and structure. Genes Chromosomes Cancer 40:298-306.
  • Ferber MJ, Eilers P, Schuuring E, Fenton JA, Fleuren GJ, Kenter G, Szuhai K, Smith DI, Raap AK, Brink AA (2004) Positioning of cervical carcinoma and Burkitt lymphoma translocation breakpoints with respect to the human papillomavirus integration cluster in FRA8C at 8q24.13. Cancer Genet Cytogenet. 154:1-9.
  • Frank HG, Gunawan B, Ebeling-Stark I, Schulten HJ, Funayama H, Cremer U, Huppertz B, Gaus G, Kaufmann P, Fuzesi L (2000) Cytogenetic and DNA-fingerprint characterization of choriocarcinoma cell lines and a trophoblast/choriocarcinoma cell hybrid. Cancer Genet Cytogenet 116: 16-22.
  • Fung J, Weier H-U G, Pedersen RA, Zitzelsberger HF (2002) Spectral analysis of metaphase and interphase cells. In: FISH-Technology, Springer-labmanual, Springer, Berlin, pp 363-387, ISBN: 3-540-67276-1.
  • Garini Y, Gil A, Bar-Am I, Cabib D, Katzir N (1999) Signal to noise analysis of multiple color fluorescencve imaging microscopy. Cytometry 35: 211-226.
  • Ghadimi BM, Sackett DL, Difilippantonio MJ, Schröck E, Neumann T, Jauho A, Auer G, Ried T (2000) Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes Chromosomes Cancer 27: 183-190.
  • Gisselsson D, Pettersson L, Hoglund M, Heidenblad M, Gorunova L, Wiegant J, Mertens F, Dal Cin P, Mitelman F, Mandahl N (2000) Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity. Proc Natl Acad Sci U S A 97: 5357-5362.
  • Goodison S, Viars C, Urquidi V (2005) Molecular cytogenetic analysis of a human breast metastasis model: identification of phenotype-specific chromosomal rearrangements. Cancer Genet Cytogenet. 2005 Jan 1;156(1):37-48.
  • Gomez GG, Varella-Garcia M, Kruse CA (2006) Isolation of immunoresistant human glioma cell clones after selection with alloreactive cytotoxic T lymphocytes: cytogenetic and molecular cytogenetic characterization. Cancer Genet Cytogenet 165:121-134.
  • Gray SG, Kytölä S, Lui WO, Larsson C, Ekstrom TJ (2000) Modulating IGFBP-3 expression by trichostatin A: potential therapeutic role in the treatment of hepatocellular carcinoma. Int J Mol Med 5: 33-41.
  • Gribble SM, Roberts I, Grace C, Andrews KM, Green AR, Nacheva EP (2000) Cytogenetics of the chronic myeloid leukemia-derived cell line K562: karyotype clarification by multicolor fluorescence in situ hybridization, comparative genomic hybridization, and locus-specific fluorescence in situ hybridization. Cancer Genet Cytogenet 118: 1-8.
  • Griffin CA, Morsberger L, Hawkins AL, Haddadin M, Patel A, Ried T, Schrock E, Perlman EJ, Jaffee E (2007) Molecular cytogenetic characterization of pancreas cancer cell lines reveals high complexity chromosomal alterations. Cytogenet Genome Res 118:148-156.
  • Grigorova M, Staines JM, Ozdag H, Caldas C, Edwards PA (2004) Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. Cytogenet Genome Res 104: 333-340.
  • Grigorova M, Lyman RC, Caldas C, Edwards PA (2005) Chromosome abnormalities in 10 lung cancer cell lines of the NCI-H series analyzed with spectral karyotyping. Cancer Genet Cytogenet. 2005 Oct 1;162(1):1-9.
  • Harada R, Uemura Y, Kobayashi M, Zamecnikova A, Nakata H, Taguchi T, Furihata M, Otsuki Y, Taguchi H (2002) Establishment and Characterization of a New Lung Cancer Cell Line (MI-4) Producing High Levels of Granulocyte Colony Stimulating Factor. Jpn J Cancer Res 93: 667-676.
  • Harding MA, Arden KC, Gildea JW, Gildea JJ, Perlman EJ, Viars C, Theodorescu D (2002) Functional genomic comparison of lineage-related human bladder cancer cell lines with differing tumorigenic and metastatic potentials by spectral karyotyping, comparative genomic hybridization, and a novel method of positional expression profiling. Cancer Res 62):6981-6989
  • Harris CP, Lu XY, Narayan G, Singh B, Murty VV, Rao PH (2003) Comprehensive molecular cytogenetic characterization of cervical cancer cell lines. Genes Chromosomes Cancer 36: 233-241.
  • Hayashida M, Daibata M, Tagami E, Taguchi T, Maekawa F, Takeoka K, Fukutsuka K, Shimomura D, Hayashi T, Iwatani Y, Ohno H (2017) Establishment and characterization of a novel Hodgkin lymphoma cell line, AM-HLH, carrying the Epstein-Barr virus genome integrated into the host chromosome. Hematol Oncol 35: 567-575
  • Henegariu O, Vance GH, Heiber D, Pera M, Heerema NA (1998) Triple-color FISH analysis of 12p amplification in testicular germ-cell tumors using 12p band-specific painting probes. J Mol Med 76: 648-655.
  • Hermsen M, Snijders A, Guervós MA, Taenzer S, Koerner U, Baak J, Pinkel D, Albertson D, van Diest P, Meijer G, Schröck E (2005) Centromeric chromosomal translocations show tissue-specific differences between squamous cell carcinomas and adenocarcinomas. Oncogene 24:1571-1579
  • Hilgenfeld E, Padilla-Nash H, Schröck E, Ried T (1999) Analysis of B-cell neoplasias by spectral karyotyping (SKY). Curr Top Microbiol Immunol 246: 169-174.
  • Jackson-Cook C, Zou Y, Turner K, Astbury C, Ware J (2003) A novel tumorigenic human prostate epithelial cell line (M2205). molecular cytogenetic characterization demonstrates C-MYC amplification and jumping translocations. Cancer Genet Cytogenet 141: 56-64
  • Jin C, Martins C, Jin Y, Wiegant J, Wennerberg J, Dictor M, Gisselsson D, Strombeck B, Fonseca I, Mitelman F, Tanke HJ, Hoglund M, Mertens F (2001). Characterization of chromosome aberrations in salivary gland tumors by FISH, including multicolor COBRA-FISH. Genes Chromosomes Cancer 30: 161-167.
  • Jin Y, Feng HC, Deng W, Zhang H, Lv M, Jin C, Tsao SW, Kwong YL (2005) Immortalization of human extravillous cytotrophoblasts by human papilloma virus gene E6E7: sequential cytogenetic and molecular genetic characterization. Cancer Genet Cytogenet 163:30-37.
  • Joyama S, Ueda T, Shimizu K, Kudawara I, Mano M, Funai H, Takemura K, Yoshikawa H (2001) Chromosome rearrangement at 17q25 and Xp11.2 in alveolar soft-part sarcoma: A case report and review of the literature. Cancer 86: 1246-1250.
  • Kadioglu O, Cao J, Kosyakova N, Mrasek K, Liehr T, Efferth T (2016) Genomic and transcriptomic profiling of resistant CEM/ADR-5000 and sensitive CCRF-CEM leukaemia cells for unraveling the full complexity of multifactorial multidrug resistance. Sci Rep 6: 36754.
  • Kakazu N, Abe T (1998) Cytogenetic analysis of chromosome abnormalities in human cancer using SKY. Experimental Medicine (Jikken Igaku) 16: 1638-1641.
  • Kalinina T, Güngör C, Thieltges S, Möller-Krull M, Penas EM, Wicklein D, Streichert T, Schumacher U, Kalinin V, Simon R, Otto B, Dierlamm J, Schwarzenbach H, Effenberger KE, Bockhorn M, Izbicki JR, Yekebas EF (2010) Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung. BMC Cancer 10:295.
  • Kawai K, Viars C, Arden K, Tarin D, Urquidi V, Goodison S (2002) Comprehensive karyotyping of the HT-29 colon adenocarcinoma cell line. Genes Chromosomes Cancer 34: 1-8.
  • Kawashima H, Ogose A, Gu W, Nishio J, Kudo N, Kondo N, Hotta T, Umezu H, Tohyama T, Nishijima H, Iwasaki H, Endo N (2005) Establishment and characterization of a novel myxofibrosarcoma cell line. Cancer Genet Cytogenet 161: 28-35.
  • Kearney L (2006) Multiplex-FISH (M-FISH): technique, developments and applications. Cytogenet Genome Res 114:189-198.
  • Kiser M, McCubrey JA, Steelman LS, Shelton JG, Ramage J, Alexander RL, Kucera GL, Pettenati M, Willingham MC, Miller MS, Frankel AE (2001) Oncogene-dependent engraftment of human myeloid leukemia cells in immunosuppressed mice. Leukemia 15: 814-818.
  • Klein A, Li N, Nicholson JM, McCormack AA, Graessmann A, Duesberg P (2010) Transgenic oncogenes induce oncogene-independent cancers with individual karyotypes and phenotypes. Cancer Genet Cytogenet 200:79-99.
  • Kleivi K, Teixeira MR, Eknaes M, Diep CB, Jakobsen KS, Hamelin R, Lothe RA (2004) Genome signatures of colon carcinoma cell lines. Cancer Genet Cytogenet 155: 119-131.
  • Knutsen T, Rao VK, Ried T, Mickley L, Schneider E, Miyake K, Ghadimi BM, Padilla-Nash H, Pack S, Greenberger L, Cowan K, Dean M, Fojo T, Bates S (2000) Amplification of 4q21-q22 and the MXR gene in independently derived mitoxantrone-resistant cell lines. Genes Chromosomes Cancer 27: 110-116.
  • Knutsen T, Gobu V, Knaus R, Padilla-Nash H, Augustus M, Strausberg RL, Kirsch IR, Sirotkin K, Ried T (2005) The interactive online SKY/M-FISH & CGH database and the Entrez cancer chromosomes search database: linkage of chromosomal aberrations with the genome sequence. Genes Chromosomes Cancer 44:52-64.
  • Knutsen T, Padilla-Nash HM, Wangsa D, Barenboim-Stapleton L, Camps J, McNeil N, Difilippantonio MJ, Ried T (2010) Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines. Genes Chromosomes Cancer 49:204-223.
  • Kost-Alimova M, Fedorova L, Yang Y, Klein G, Imreh S (2004) Microcell-mediated chromosome transfer provides evidence that polysomy promotes structural instability in tumor cell chromosomes through asynchronous replication and breakage within late-replicating regions. Genes Chromosomes Cancer 40:316-324.
  • Kovalchuk AL, Esa A, Coleman AE, Park SS, Ried T, Cremer CC, Janz S (2001) Translocation remodeling in the primary BALB/c plasmacytoma TEPC 3610. Genes Chr Cancer 30: 283-291.
  • Kraus J, Pantel K, Pinkel D, Albertson DG, Speicher MR (2003) High -resolution genomic profiling of occult micrometastatic tumor cells. Genes Chromosomes Cancer 36: 159-166.
  • Krex D, Mohr B, Hauses M, Ehninger G, Schackert HK, Schackert G (2001) Identification of uncommon chromosomal aberrations in the neuroglioma cell line H4 by spectral karyotyping. J Neurooncol.22: 119-128.
  • Krupp W, Geiger K, Schober R, Siegert G, Froster UG (2004) Cytogenetic and molecular cytogenetic analyses in diffuse astrocytomas. Cancer Genet Cytogenet 153:32-38.
  • Kubota H, Nishizaki T, Harada K, Harada K, Oga A, Ito H, Suzuki M, Sasaki K (2001) Identification of recurrent chromosomal rearrangements and the unique relationship between low-level amplification and translocation in gliablastoma. Genes Chr Cancer 31: 125-133.
  • Kume M, Taguchi T, Okada H, Anayama T, Tominaga A, Shuin T, Sasaguri S (2007) Establishment and molecular cytogenetic characterization of non-small cell lung cancer cell line KU-T1 by multicolor fluorescence in situ hybridization, comparative genomic hybridization, and chromosome microdissection. Cancer Genet Cytogenet 179:93-101
  • Kytölä S, Rummukainen J, Nordgren A, Karhu R, Farnebo F, Isola J, Larsson C (2000) Chromosomal alterations in 15 breast cancer cell lines by comparative genomic hybridization and spectral karyotyping. Genes Chromosomes Cancer 28: 308-317.
  • Langer S, Geigl JB, Ehnle S, Gangnus R, Speicher MR (2005) Live cell catapulting and recultivation does not change the karyotype of HCT116 tumor cells. Cancer Genet Cytogenet 161:174-177.
  • Li R, Hehlman R, Sachs R, Duesberg P (2005) Chromosomal alterations cause the high rates and wide ranges of drug resistance in cancer cells. Cancer Genet Cytogenet 163:44-56.
  • Li L, McCormack AA, Nicholson JM, Fabarius A, Hehlmann R, Sachs RK, Duesberg PH (2009) Cancer-causing karyotypes: chromosomal equilibria between destabilizing aneuploidy and stabilizing selection for oncogenic function. Cancer Genet Cytogenet 188:1-25.
  • Liang JC, Ning Y, Wang RY, Padilla-Nash HM, Schröck E, Soenksen D, Nagarajan L, Ried T (1999) Spectral karyotypic study of the HL-60 cell line: detection of complex rearrangements involving chromosomes 5, 7, and 16 and delineation of critical region of deletion on 5q31.1. Cancer Genet Cytogenet 113: 105-109.
  • Lim G, Karaskova J, Vukovic B, Bayani J, Beheshti B, Bernardini M, Squire JA, Zielenska M (2004) Combined spectral karyotyping, multicolor banding, and microarray comparative genomic hybridization analysis provides a detailed characterization of complex structural chromosomal rearrangements associated with gene amplification in the osteosarcoma cell line MG-63. Cancer Genet Cytogenet. 153:158-164.
  • Lim G, Karaskova J, Beheshti B, Vukovic B, Bayani J, Selvarajah S, Watson SK, Lam WL, Zielenska M, Squire JA (2005) An integrated mBAND and submegabase resolution tiling set (SMRT) CGH array analysis of focal amplification, microdeletions, and ladder structures consistent with breakage-fusion-bridge cycle events in osteosarcoma. Genes Chr Cancer 42: 392-403.
  • Lindbjerg Andersen C, Ostergaard M, Nielsen B, Pedersen B, Koch J (2000) Characterization of three hairy cell leukemia- derived cell lines (ESKOL, JOK-1, and hair-M) by multiplex-FISH, comparative genomic hybridization, FISH, PRINS, and dideoxyPRINS. Cytogenet Cell Genet 90: 330-9.
  • Loja T, Chlapek P, Kuglik P, Pesakova M, Oltova A, Cejpek P, Veselska R (2009) Characterization of a GM7 glioblastoma cell line showing CD133 positivity and both cytoplasmic and nuclear localization of nestin. Oncol Rep 21:119-127.
  • Lopez JR, Claessen SM, Macville MV, Albrechts JC, Skogseid B, Speel EJ (2010) Spectral karyotypic and comparative genomic analysis of the endocrine pancreatic tumor cell line BON-1. Neuroendocrinology 91:131-141.
  • Lu YJ, Morris JS, Edwards PA, Shipley J (2000) Evaluation of 24-color multifluor-fluorescence in-situ hybridization (M-FISH) karyotyping by comparison with reverse chromosome painting of the human breast cancer cell line T-47D. Chromosome Res 8: 127-132.
  • Luan Y, Kogi M, Rajaguru P, Ren J, Yamaguchi T, Suzuki K, Suzuki T (2012) Microarray analysis of responsible genes in increased growth rate in the subline of HL60 (HL60RG) cells. Mutat Res 731:20-26.
  • MacLeod RA, Nagel S, Kaufmann M, Greulich-Bode K, Drexler HG (2002) Multicolor-FISH analysis of a natural killer cell line (NK-92). Leuk Res 26:1027-1033
  • Macleod RA, Kaufmann M, Drexler HG (2011) Cytogenetic analysis of cancer cell lines. Methods Mol Biol 731:57-78.
  • Macoska JA, Paris P, Collins C, Andaya A, Beheshti B, Chaib H, Kant R, Begley L, MacDonald JW, Squire JA (2004) Evolution of 8p loss in transformed human prostate epithelial cells. Cancer Genet Cytogenet 154:36-43.
  • Mao X, James SY, Yanez-Munoz RJ, Chaplin T, Molloy G, Oliver RT, Young BD, Lu YJ (2007) Rapid high-resolution karyotyping with precise identification of chromosome breakpoints. Genes Chromosomes Cancer 46:675-683.
  • Martinez-Ramirez A, Rodriguez-Perales S, Melendez B, Martinez-Delgado B, Urioste M, Cigudosa JC, Benitez J (2003) Characterization of the A673 cell line (Ewing tumor) by molecular cytogenetic techniques. Cancer Genet Cytogenet 141: 138-142.
  • Matsuhashi Y, Tasaka T, Kakazu N, Nagai M, Sadahira K, Nishida K, Taniwaki M, Abe T, Ishida T (2007) Establishment and characterization of the new splenic marginal zone lymphoma-derived cell line UCH1 carrying a complex rearrangement involving t(8;14) and chromosome 3. Leuk Lymphoma 48:767-773
  • Matsui S, Faitar SL, Rossi MR, Cowell JK (2003) Application of spectral karyotyping to the analysis of the human chromosome complement of interspecies somatic cell hybrids. Cancer Genet Cytogenet 142: 30-35.
  • Macoska JA, Beheshti B, Rhim JS, Hukku B, Lehr J, Pienta KJ, Squire JA (2000) Genetic characterization of immortalized human prostate epithelial cell cultures. Evidence for structural rearrangements of chromosome 8 and i(8q) chromosome formation in primary tumor-derived cells. Cancer Genet Cytogenet 120: 50-57.
  • Macville M, Veldman T, Padilla-Nash H, Wangsa D, O'Brien P, Schröck E, Ried T (1997) Spectral karyotyping, a 24-colour FISH technique for the identification of chromosomal rearrangements. Histochem Cell Biol 108: 299-305.
  • Macville M, Schröck E, Padilla-Nash H, Keck C, Ghadimi BM, Zimonjic D, Popescu N, Ried T (1999) Comprehensive and definitive molecular cytogenetic characterization of HeLa cells by spectral karyotyping. Cancer Res 59: 141-150.
  • Mairal A, Chibon F, Rousselet A, Couturier J, Terrier P, Aurias A (2000) Establishment of a human malignant fibrous histiocytoma cell line, COMA. Characterization By conventional cytogenetics, comparative genomic hybridization, and multiplex fluorescence In situ hybridization. Cancer Genet Cytogenet 121: 117-123.
  • Marella NV, Zeitz MJ, Malyavantham KS, Pliss A, Matsui S, Goetze S, Bode J, Raska I, Berezney R (2008) Ladder-like amplification of the type I interferon gene cluster in the human osteosarcoma cell line MG63. Chromosome Res 16:1177-1192.
  • Matsui S, LaDuca J, Rossi MR, Nowak NJ, Cowell JK (2005) Molecular characterization of a consistent 4.5-megabase deletion at 4q28 in prostate cancer cells. Cancer Genet Cytogenet 159:18-26.
  • McGhee EM, Cotter PD, Weier JF, Berline JW, Turner MA, Gormley M, Palefsky JM (2006) Molecular cytogenetic characterization of human papillomavirus16-transformed foreskin keratinocyte cell line 16-MT. Cancer Genet Cytogenet 168: 36-43.
  • Mehra S, Messner H, Minden M, Chaganti RS (2002) Molecular cytogenetic characterization of non-Hodgkin lymphoma cell lines. Genes Chromosomes Cancer 33: 225-234.
  • Melcher R, Steinlein C, Feichtinger W, Müller CR, Menzel T, Luhrs H, Scheppach W, Schmid M (2000) Spectral karyotyping of the human colon cancer cell lines SW480 and SW620. Cytogenet Cell Genet 88: 145-152.
  • Melcher R, Koehler S, Steinlein C, Schmid M, Mueller CR, Luehrs H, Menzel T, Scheppach W, Moerk H, Scheurlen M, Koehrle J, Al-Taie O (2002) Spectral karyotype analysis of colon cancer cell lines of the tumor suppressor and mutator pathway. Cytogenet Genome Res 98:22-28.
  • Melcher R, Koehler S, Steinlein C, Schmid M, Mueller CR, Luehrs H, Menzel T, Scheppach W, Moerk H, Scheurlen M, Koehrle J, Al-Taie O (2003) Spectral karyotype analysis of colon cancer cell lines of the tumor suppressor and mutator pathway. Cytogenet Genome Res 98: 22-28.
  • Melcher R, Maisch S, Koehler S, Bauer M, Steinlein C, Schmid M, Kudlich T, Schauber J, Luehrs H, Menzel T, Scheppach W (2005) SKY and genetic fingerprinting reveal a cross-contamination of the putative normal colon epithelial cell line NCOL-1. Cancer Genet Cytogenet 158:84-87.
  • Meyer S, Fergusson WD, Whetton AD, Moreira-Leite F, Pepper SD, Miller C, Saunders EK, White DJ, Will AM, Eden T, Ikeda H, Ullmann R, Tuerkmen S, Gerlach A, Klopocki E, Tönnies H (2007) Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia-derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption. Genes Chromosomes Cancer 46: 359-372.
  • Misra A, Pellarin M, Shapiro JR, Feuerstein BG (2004) A complex rearrangement of chromosome 7 in human astrocytoma. Cancer Genet Cytogenet. 151: 162-170.
  • Mohr B, Illmer T (2005) Structural chromosomal aberrations in the colon cancer cell line HCT 116 - results of investigations based on spectral karyotyping. Cytogenet Genome Res 108: 359-361.
  • Mozziconacci MJ, Rosenauer A, Restouin A, Fanelli M, Shao W, Fernandez F, Toiron Y, Viscardi J, Gambacorti-Passerini C, Miller WH Jr, Lafage-Pochitaloff M (2002) Molecular cytogenetics of the acute promyelocytic leukemia-derived cell line NB4 and of four all-trans retinoic acid-resistant subclones. Genes Chromosomes Cancer 35: 261-270.
  • Mrózek K, Tanner SM, Heinonen K, Bloomfield CD (2003) Molecular cytogenetic characterization of the KG-1 and KG-1a acute myeloid leukemia cell lines by use of spectral karyotyping and fluorescence in situ hybridization. Genes Chromosomes Cancer 38:249-252
  • Murillo H, Schmidt LJ, Karter M, Hafner KA, Kondo Y, Ballman KV, Vasmatzis G, Jenkins RB, Tindall DJ (2006) Prostate cancer cells use genetic and epigenetic mechanisms for progression to androgen independence. Genes Chromosomes Cancer 45:702-716.
  • Nestor AL, Hollopeter SL, Matsui SI, Allison D (2007) A model for genetic complementation controlling the chromosomal abnormalities and loss of heterozygosity formation in cancer. Cytogenet Genome Res 116:235-247.
  • Neveling K, Kalb R, Florl AR, Herterich S, Friedl R, Hoehn H, Hader C, Hartmann FH, Nanda I, Steinlein C, Schmid M, Tönnies H, Hurst CD, Knowles MA, Hanenberg H, Schulz WA, Schindler D (2007) Disruption of the FA/BRCA pathway in bladder cancer. Cytogenet Genome Res 118:166-176.
  • Nishio J, Iwasaki H, Nabeshima K, Ishiguro M, Naumann S, Isayama T, Naito M, Kaneko Y, Kikuchi M, Bridge JA (2005) Establishment of a new human epithelioid sarcoma cell line, FU-EPS-1: molecular cytogenetic characterization by use of spectral karyotyping and comparative genomic hybridization. Int J Oncol 27: 361-369.
  • Nishio J, Iwasaki H, Nabeshima K, Ishiguro M, Isayama T, Naito M (2010) Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization. J Exp Clin Cancer Res 29:153.
  • Odero MD, Zeleznik-Le NJ, Chinwalla V, Rowley JD (2000) Cytogenetic and molecular analysis of the acute monocytic leukemia cell line THP-1 with an MLL-AF9 translocation. Genes Chromosomes Cancer 29: 333-338.
  • Olnes MJ, Poon A, Miranda SJ, Pfannes L, Tucker Z, Loeliger K, Padilla-Nash H, Yau YY, Ried T, Leitman SF, Young NS, Sloand EM (2012) Effects of granulocyte-colony-stimulating factor on Monosomy 7 aneuploidy in healthy hematopoietic stem cell and granulocyte donors. Transfusion 52:537-541.  
  • Ouyang H, Mou L, Luk C, Liu N, Karaskova J, Squire J, Tsao MS (2000) Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype. Am J Pathol 157: 1623-1631.
  • Ozaki T, Neumann T, Wai D, Schäfer K-L, van valen F, Lindner N, Scheel C, Böcker W, Winkelmann W, Dockhorn-Dworniczak B, Horst J, Poremba C (2003) Chromosomal alterations in osteosarcoma cell lines revealed by comparative genomic hybridization and multicolor karyotyping. Cancer Genet Cytogenet 140: 145-152.
  • Paderova J, Orlic-Milacic M, Yoshimoto M, da Cunha Santos G, Gallie B, Squire JA (2007) Novel 6p rearrangements and recurrent translocation breakpoints in retinoblastoma cell lines identified by spectral karyotyping and mBAND analyses. Cancer Genet Cytogenet 179:102-111.
  • Padilla-Nash HM, Nash WG, Padilla GM, Roberson KM, Robertson CN, Macville M, Schröck E, Ried T (1999) Molecular cytogenetic analysis of the bladder carcinoma cell line BK-10 by spectral karyotyping. Genes Chromosomes Cancer 25: 53-59.
  • Padilla-Nash HM, Heselmeyer-Haddad K, Wangsa D, Zhang H, Ghadimi BM, Macville M, Augustus M, Schrock E, Hilgenfeld E, Ried T (2001) Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms. Genes Chromosomes Cancer 30: 349-363.
  • Pan Y, Kytölä S, Farnebo F, Wang N, Lui WO, Nupponen N, Isola J, Visakorpi T, Bergerheim US, Larsson C (1999) Characterization of chromosomal abnormalities in prostate cancer cell lines by spectral karyotyping. Cytogenet Cell Genet 87: 225-232.
  • Pan Y, Lui WO, Nupponen N, Larsson C, Isola J, Visakorpi T, Bergerheim US, Kytölä S (2001) 5q11, 8p11, and 10q22 are recurrent chromosomal breakpoints in prostate cancer cell lines. Genes Chromosomes Cancer 30: 187-195.
  • Pandita A, Zielenska M, Thorner P, Bayani J, Godbout R, Greenberg M, Squire JA (1999) Application of comparative genomic hybridization, spectral karyotyping, and microarray analysis in the identification of subtype-specific patterns of genomic changes in rhabdomyosarcoma. Neoplasia 1: 262-275.
  • Pandita A, Bayani J, Paderova J, Marrano P, Graham C, Barrett M, Prasad M, Zielenska M, Squire JA (2011) Integrated cytogenetic and high-resolution array CGH analysis of genomic alterations associated with MYCN amplification. Cytogenet Genome Res 134:27-39.
  • Pang E, Wong N, Lai PB, To KF, Lau JW, Johnson PJ (2000) A comprehensive karyotypic analysis on a newly developed hepatocellular carcinoma cell line, HKCI-1, by spectral karyotyping and comparative genomic hybridization. Cancer Genet Cytogenet 121: 9-16.
  • Pang E, Wong N, Lai P B-S, To K-F, Lau W-Y, Johnson PJ (2002) Consistent chromosome 10 rearrangements in four newly established human hepatocellular carcinoma cell lines. Genes Chromosomes Cancer 33: 150-159.
  • Pappas JJ, Toulouse A, Hébert J, Fetni R, Bradley WE (2008) Allelic methylation bias of the RARB2 tumor suppressor gene promoter in cancer. Genes Chromosomes Cancer 47):978-993.
  • Parker H, Cheung KL, Robinson HM, Harrison CJ, Strefford JC (2008) Cytogenetic and genomic characterization of cell line ARH77. Cancer Genet Cytogenet 181:40-45
  • Pavlovich CP, Padilla-Nash H, Wangsa D, Nickerson ML, Matrosova V, Linehan WM, Ried T, Phillips JL (2003) Patterns of aneuploidy in stage IV clear cell renal cell carcinoma revealed by comparative genomic hybridization and spectral karyotyping. Genes Chromosomes Cancer 37: 252-260.
  • Pedrazzini E, Mamaev N, Yakovleva T, Sukhikh T, Salido M, Sole F, Prat E, Camps J, Miro R, Slavutsky I (2003) Genomic rearrangements involving rDNA and centromeric heterochromatin in vulvar epidermoid carcinoma cell line A-431. Cancer Genet Cytogenet 143: 50-58.
  • Pelz AF, Weilepp G, Wieacker PF (2005) Re-analysis of the cell line NALM-1 karyotype by GTG-banding, spectral karyotyping, and whole chromosome painting. Cancer Genet Cytogenet 156:59-61.
  • Perissel B, Giollant M, Dastugue N, Penault-Llorca F, Jaffray JY, Guy L, Boiteux JP, Kemeny JL, Fonck Y, Boucher D (2000) New cytogenetic data on bladder carcinoma cell line (CHA89) revealed by M-FISH analysis. Cancer Genet Cytogenet 121: 228-229.
  • Persson F, Winnes M, Andrén Y, Wedell B, Dahlenfors R, Asp J, Mark J, Enlund F, Stenman G (2008) High-resolution array CGH analysis of salivary gland tumors reveals fusion and amplification of the FGFR1 and PLAG1 genes in ring chromosomes. Oncogene 27: 3072-3080.
  • Persson F, Olofsson A, Sjögren H, Chebbo N, Nilsson B, Stenman G, Aman P (2008) Characterization of the 12q amplicons by high-resolution, oligonucleotide array CGH and expression analyses of a novel liposarcoma cell line. Cancer Lett 260:37-47.
  • Persson F, Winnes M, Andrén Y, Wedell B, Dahlenfors R, Asp J, Mark J, Enlund F, Stenman G (2008) High-resolution array CGH analysis of salivary gland tumors reveals fusion and amplification of the FGFR1 and PLAG1 genes in ring chromosomes. Oncogene 27:3072-3080.
  • Popescu NC, Zimonjic (1997) Molecular cytogenetic characterization of cancer cell alterations. Cancer Genet Cytogenet 93: 10-21.
  • Popovici C, Basset C, Bertucci F, Orsetti B, Adelaide J, Mozziconacci MJ, Conte N, Murati A, Ginestier C, Charafe-Jauffret E, Ethier SP, Lafage-Pochitaloff M, Theillet C, Birnbaum D, Chaffanet M (2002) Reciprocal translocations in breast tumor cell lines: Cloning of a t(3;20) that targets the FHIT gene. Genes Chromosomes Cancer 35: 204-218.
  • Prasad M, Bernardini M, Tsalenko A, Marrano P, Paderova J, Lee CH, Ben-Dor A, Barrett MT, Squire JA (2008) High definition cytogenetics and oligonucleotide aCGH analyses of cisplatin-resistant ovarian cancer cells. Genes Chromosomes Cancer 47:427-436.
  • Prowald A, Wemmert S, Biehl C, Storck S, Martin T, Henn W, Ketter R, Meese E, Zang KD, Steudel WI, Urbschat S (2005) Interstitial loss and gain of sequences on chromosome 22 in meningiomas with normal karyotype. Int J Oncol 26:385-393.
  • Rao VK (1998) Course in advanced moleculart cytogenetics. Pathology 30: 428-429.
  • Rao VK, Wangsa D, Robey RW, Huff L, Honjo Y, Hung J, Knutsen T, Ried T, Bates SE. (2005) Characterization of ABCG2 gene amplification manifesting as extrachromosomal DNA in mitoxantrone-selected SF295 human glioblastoma cells. Cancer Genet Cytogenet. Cytogenet 160: 126-133.
  • Ratliff TL (2005) Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro. J Urol 174:2065
  • Rennstam K, Jonsson G, Tanner M, Bendahl PO, Staaf J, Kapanen AI, Karhu R, Baldetorp B, Borg A, Isola J (2007) Cytogenetic characterization and gene expression profiling of the trastuzumab-resistant breast cancer cell line JIMT-1. Cancer Genet Cytogenet 172:95-106.
  • Ribeiro IP, Rodrigues JM, Mascarenhas A, Kosyakova N, Caramelo F, Liehr T, Melo JB, Carreira IM (2018) Cytogenetic, genomic, and epigenetic characterization of the HSC-3 tongue cell line with lymph node metastasis. J Oral Sci 60:70-81.
  • Riches A, Peddie C, Rendell S, Bryant P, Zitzelsberger H, Bruch J, Smida J, Hieber L, Bauchinger M (2001) Neoplastic transformation and cytogenetic changes after Gamma irradiation of human epithelial cells expressing telomerase. Radiat Res 155: 222-229.
  • Roberts I, Wienberg J, Nacheva E, Grace C, Griffin D, Coleman N (1999) Novel method for the production of multiple colour chromosome paints for use in karyotyping by fluorescence in situ hybridisation. Genes Chromosomes Cancer 25:241-250.
  • Roberts I, Gordon A, Wang R, Pritchard-Jones K, Shipley J, Coleman N (2001) Molecular cytogenetic analysis consistently identifies translocations involving chromosomes 1, 2 and 15 in five embryonal rhabdomyosarcoma cell lines and a PAX-FOXO1A fusion gene negative alveolar rhabdomyosarcoma cell line. Cytogenet Cell Genet 95: 134-142.
  • Rodriguez-Perales S, Marti;nez-Rami;rez A, de Andres SA, Valle L, Urioste M, Beni;tez J, Cigudosa JC (2004) Molecular cytogenetic characterization of rhabdomyosarcoma cell lines. Cancer Genet Cytogenet 148:35-43.
  • Rogalla P, Helbig R, Drieschner N, Flohr AM, Krohn M, Bullerdiek J (2002) Molecular-cytogenetic analysis of fragmentation of chromosome 17 in the breast cancer cell line EFM-19. Anticancer Res 22:1987-1992
  • Rosenberg C, Geelen E, IJszenga MJ, Pearson P, Tanke HJ, Dinjens WN, van Dekken H (2002) Spectrum of genetic changes in gastro-esophageal cancer cell lines determined by an integrated molecular cytogenetic approach. Cancer Genet Cytogenet 135: 35-41.
  • Rubio D, Garcia-Castro J, Martin MC, de la Fuente R, Cigudosa JC, Lloyd AC, Bernad A (2005) Spontaneous human adult stem cell transformation. Cancer Res 65:3035-3039.
  • Rudolph C, Steinemann D, Von Neuhoff N, Gadzicki D, Ripperger T, Drexler HG, Mrasek K, Liehr T, Claussen U, Emura M, Schröck E, Schlegelberger B (2004) Molecular cytogenetic characterization of the mantle cell lymphoma cell line GRANTA-519. Cancer Genet Cytogenet 153: 144-150.
  • Rummukainen J, Kytola S, Karhu R, Farnebo F, Larsson C, Isola JJ (2001) Aberrations of chromosome 8 in 16 breast cancer cell lines by comparative genomic hybridization, fluorescence in situ hybridization, and spectral karyotyping. Cancer Genet Cytogenet 126: 1-7.
  • Salido M, Arriola E, Carracedo A, Cañadas I, Rovira A, Espinet B, Rojo F, Arumi M, Serrano S, Albanell J, Sole F (2009) Cytogenetic characterization of NCI-H69 and NCI-H69AR small cell lung cancer cell lines by spectral karyotyping. Cancer Genet Cytogenet 191:97-101.
  • Sallinen SL, Sallinen P, Ahlstedt-Soini M, Haapasalo H, Helin H, Isola J, Karhu R (2003) Arm-specific multicolor fluorescence in situ hybridization reveals widespread chromosomal instability in glioma cell lines. Cancer Genet Cytogenet 144: 52-60.
  • Samassekou O, Bastien N, Lichtensztejn D, Yan J, Mai S, Drouin R (2014) Different TP53 mutations are associated with specific chromosomal rearrangements, telomere length changes, and remodeling of the nuclear architecture of telomeres. Genes Chromosomes Cancer 53: 934-950.
  • Sarraf S, Tejada R, Abawi M, Oberst M, Dennis T, Simon KC, Blancato J (2005) The human ovarian teratocarcinoma cell line PA-1 demonstrates a single translocation: analysis with fluorescence in situ hybridization, spectral karyotyping, and bacterial artificial chromosome microarray. Cancer Genet Cytogenet 161:63-69.
  • Sargent LM, Nelson MA, Lowry DT, Senft JR, Jefferson AM, Ariza ME, Reynolds SH (2001) Detection of three novel translocations and specific common chromosomal break sites in malignant melanoma by spectral karyotyping. Genes Chr Cancer 32: 18-25.
  • Satoh T, Yamamoto K, Miura KF, Ishidato M, Jr. (1998) Cytogenetic analysis of heteromorphic short arm of 15p+ in a human diploid cell strain, TIG-7. Chromosome Science 2: 57-62.
  • Saunders WS, Shuster M, Huang X, Gharaibeh B, Enyenihi AH, Petersen I, Gollin SM (2000) Chromosomal instability and cytoskeletal defects in oral cancer cells. Proc Natl Acad Sci U S A 97: 303-308.
  • Schaeferhenrich A, Sendt W, Scheele J, Kuechler A, Liehr T, Claussen U, Rapp A, Greulich KO, Pool-Zobel BL (2003) Putative colon cancer risk factors damage global DNA and TP53 in primary human colon cells isolated from surgical samples. Food Chem Toxicol 41: 655-664.
  • Scheil S, Brüderlein S, Liehr T, Starke H, Herms J, Schulte M, Möller P (2001) Genome wide analysis of sixteen chordomas by comparative genomic hybridization and cytogenetics of the first human chordoma cell line, U-CH1. Genes Chr Cancer 32:203-211.
  • Scheil S, Hagen S, Brüderlein S, Leuschner I, Behnisch W, Möller P (2003) Two novel in vitro human hepatoblastoma models, HepU1 and HepU2, are highly characteristic of fetal-embryonal differentiation in hepatoblastoma. Int J Cancer 105:347-352
  • Schlade-Bartusiak K, Sasiadek MM, Bar JK, Urbschat S, Blin N, Montenarh M, Harlozinska-Szmyrka A (2006) Cytogenetic and molecular cytogenetic characterization of the stable ovarian carcinoma cell line (OvBH-1). Cancer Genet Cytogenet 164: 10-15.
  • Schleiermacher G, Janoueix-Lerosey I, Combaret V, Derré J, Couturier J, Aurias A, Delattre O (2003) Combined 24-color karyotyping and comparative genomic hybridization analysis indicates rearrangements of early replicating chromosome regions in neuroblastoma. Cancer Genet Cytogenet 141: 32-42.
  • Schmitz S, Pinkawa M, Eble MJ, Kriehuber R (2013) Persisting ring chromosomes detected by mFISH in lymphocytes of a cancer patient-a case report. Mutat Res 756:158-164.
  • Schop RF, Kuehl WM, Van Wier SA, Ahmann GJ, Price-Troska T, Bailey RJ, Jalal SM, Qi Y, Kyle RA, Greipp PR, Fonseca R (2002) Waldenström macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletions. Blood 100:2996-3001
  • Schröck E, du Manoir S, Veldman T, Schoell B, Wienberg J, Ferguson-Smith MA, Ning Y, Ledbetter DH, Bar-Am I, Soenksen D, Garini Y, Ried T (1996) Multicolor spectral karyotyping of human chromosomes. Science, 273:494-497.
  • Schulten HJ, Gunawan B, Otto F, Hassmann R, Hallermann C, Noebel A, Fuzesi L (2002) Cytogenetic characterization of complex karyotypes in seven established melanoma cell lines by multiplex fluorescence in situ hybridization and DAPI banding. Cancer Genet Cytogenet 133: 134-141.
  • Schulten HJ, Perske C, Thelen P, Polten A, Borst C, Gunawan B, Nagel H (2007) Establishment and characterization of two distinct malignant mesothelioma cell lines with common clonal origin. Cancer Genet Cytogenet 176:35-47.
  • Shen H, Zhu Y, Wu YJ, Qiu HR, Shu YQ (2008) Genomic alterations in lung adenocarcinomas detected by multicolor fluorescence in situ hybridization and comparative genomic hybridization. Cancer Genet Cytogenet 181:100-107
  • Shing DC, Morley-Jaboc CA, Roberts I, Nacheva E, Coleman N (2002) Ewing's tumour: novel recurrent chromosomal abnormalities demonstrated by molecular cytogenetic analysis of seven cell lines and one primary culture. Cytogenet Genome Res 97: 20-27.
  • Singh B, Gogineni S, Goberdhan A, Sacks P, Shaha A, Shah J, Rao P (2001) Spectral karyotyping analysis of head and neck squamous cell carcinoma. Laryngoscope 111:1545-1550.
  • Siwicki JK, Berglund M, Rygier J, Pienkowska-Grela B, Grygalewicz B, Degerman S, Golovleva I, Chrzanowska KH, Lagercrantz S, Blennow E, Roos G, Larsson C (2004) Spontaneously immortalized human T lymphocytes develop gain of chromosomal region 2p13-24 as an early and common genetic event. Genes Chromosomes Cancer 41:133-144.
  • Snijders AM, Hermsen MA, Baughman J, Buffart TE, Huey B, Gajduskova P, Roydasgupta R, Tokuyasu T, Meijer GA, Fridlyand J, Albertson DG (2008) Acquired genomic aberrations associated with methotrexate resistance vary with background genomic instability.Genes Chromosomes Cancer 47:71-83
  • Speicher MR, Gwyn Ballard S, Ward DC (1996) Karyotyping human chromosomes by combinatorial multi-fluor FISH. Nat Genet 12: 368-375.
  • Soler D, Genesca A, Arnedo G, Egozcue J, Tusell L (2005) Telomere dysfunction drives chromosomal instability in human mammary epithelial cells. Genes Chromosomes Cancer 44:339-350.
  • Squire JA, Arab S, Marrano P, Bayani J, Karaskova J, Taylor M, Becker L, Rutka J, Zielenska M (2001) Molecular cytogenetic analysis of glial tumors using spectral karyotyping and comparative genomic hybridization.Mol Diagn 6: 93-108.
  • Strefford JC, Lillington DM, Young BD, Oliver RT (2001) The use of multicolor fluorescence technologies in the characterization of prostate carcinoma cell lines. a comparison of multiplex fluorescence in situ hybridization and spectral karyotyping data. Cancer Genet Cytogenet 124: 112-121.
  • Strefford JC, Foot NJ, Chaplin T, Neat MJ, Oliver RT, Young BD, Jones LK (2001) The characterisation of the lymphoma cell line U937, using comparative genomic hybridisation and multi-plex FISH. Cytogenet Cell Genet 94:9-14.
  • Strefford JC, Lillington DM, Steggall M, Lane TM, Nouri AM, Young BD, Oliver RT (2002) Novel chromosome findings in bladder cancer cell lines detected with multiplex fluorescence in situ hybridization. Cancer Genet Cytogenet 135: 139-146.
  • Strefford JC, Stasevich I, Lane TM, Lu YJ, Oliver T, Young BD (2005) A combination of molecular cytogenetic analyses reveals complex genetic alterations in conventional renal cell carcinoma. Cancer Genet Cytogenet 159:1-9.
  • Subramaniam M, Jalal SM, Rickard DJ, Harris SA, Bolander ME, Spelsberg TC (2002) Further characterization of human fetal osteoblastic hFOB 1.19 and hFOB/ERalpha cells: Bone formation in vivo and karyotype analysis using multicolor fluorescent in situ hybridization. J Cell Biochem 87: 9-15.
  • Summersgill BM, Jafer O, Wang R, Goker H, Niculescu-Duvaz I, Huddart R, Shipley J (2001) Definition of chromosome aberrations in testicular germ cell tumor cell lines by 24-color karyotyping and complementary molecular cytogenetic analyses. Cancer Genet Cytogenet 128: 120-129.
  • Szuhai K, Bezrookove V, Wiegant J, Vrolijk J, Dirks RW, Rosenberg C, Raap AK, Tanke HJ (2000) Simultaneous molecular karyotyping and mapping of viral DNA integration sites by 25-color COBRA-FISH. Genes Chr Cancer 28: 92-97.
  • Tai AL, Fang Y, Sham JS, Deng W, Hu L, Xie D, Tsao GS, Cheung AL, Guan XY (2005) Establishment and characterization of a human non-small cell lung cancer cell line. Oncol Rep 13:1029-1032
  • Tai AL, Sham JS, Xie D, Fang Y, Wu YL, Hu L, Deng W, Tsao GS, Qiao GB, Cheung AL, Guan XY (2006) Co-overexpression of fibroblast growth factor 3 and epidermal growth factor receptor is correlated with the development of nonsmall cell lung carcinoma. Cancer 106:146-155.
  • Tönnies H (2005) Molecular cytogenetics in molecular diagnostics. In Molecular Diagnostics, Ed. Patrinos and Ansorge: 139-157.
  • Tonon G, Roschke A, Stover K, Shou Y, Kuehl WM, Kirsch IR (2000) Spectral karyotyping combined with locus-specific FISH simultaneously defines genes and chromosomes involved in chromosomal translocations. Genes Chromosomes Cancer 27: 418-423.
  • Tonon G, Gehlhaus KS, Yonescu R, Kaye FJ, Kirsch IR (2004) Multiple reciprocal translocations in salivary gland mucoepidermoid carcinomas. Cancer Genet Cytogenet 152:15-22.
  • Tosi S, Giudici G, Rambaldi A, Scherer SW, Bray-Ward P, Dirscherl L, Biondi A, Kearney L (1999) Characterization of the human myeloid leukemia-derived cell line GF-D8 by multiplex fluorescence in situ hybridization, subtelomeric probes, and comparative genomic hybridization. Genes Chromosomes Cancer 24: 213-221.
  • Tsushimi T, Noshima S, Oga A, Esato K, Sasaki K (2001) DNA amplification and chromosomal translocations are accompanied by chromosomal instability: analysis of seven human colon cancer cell lines by comparative genomic hybridization and spectral karyotyping.Cancer Genet Cytogenet 126: 34-38.
  • Uchida K, Oga A, Okafuji M, Mihara M, Kawauchi S, Furuya T, Chochi Y, Ueyama Y, Sasaki K (2006) Molecular cytogenetic analysis of oral squamous cell carcinomas by comparative genomic hybridization, spectral karyotyping, and fluorescence in situ hybridization. Cancer Genet Cytogenet 167: 109-116.
  • Uneda S, Gotoh M, Sonoki T, Nishida K, Nakamura Y, Kurimoto M, Hanaoka N, Matsuoka H, Taniwaki M, Nakakuma H (2008) Establishment of CD5 and CD10 double-positive mature B-cell line, WILL1, showing complex 8q24 translocation involving 14q32 and 6q27. Int J Hematol 88:536-542.
  • van Bokhoven A, Caires A, Maria MD, Schulte AP, Lucia MS, Nordeen SK, Miller GJ, Varella-Garcia M (2003) Spectral karyotype (SKY) analysis of human prostate carcinoma cell lines. Prostate 57:226-244
  • Van Gele M, Leonard JH, Van Roy N, Van Limbergen H, Van Belle S, Cocquyt V, Salwen H, De Paepe A, Speleman F (2002) Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma. Int J Cancer 101: 137-145.
  • Van Roy N, Van Limbergen H, Vandesompele J, Van Gele M, Poppe B, Laureys G, De Paepe A, Speleman F (2000) Chromosome 2 short arm translocations revealed by M-FISH analysis of neuroblastoma cell lines. Med Pediatr Oncol 35: 538-540.
  • Van Roy N, Van Limbergen H, Vandesompele J, Van Gele M, Poppe B, Salwen H, Laureys G, Manoel N, De Paepe A, Speleman F (2001) Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines. Genes Chr Cancer 32: 126-135.
  • Varella-Garcia M, Boomer T, Miller GJ (2001) Karyotypic similarity identified by multiplex-FISH relates four prostate adenocarcinoma cell lines: PC-3, PPC-1, ALVA-31, and ALVA-41. Genes Chr Cancer 31: 303-315.
  • Varella-Garcia M, Chen L, Zheng X, Yu L, Dixon D (2006) Karyotypic characteristics of human uterine leiomyoma and myometrial cell lines following telomerase induction. Cancer Genet Cytogenet 170: 71-75.
  • Vaziri H, Squire JA, Pandita TK, Bradley G, Kuba RM, Zhang H, Gulyas S, Hill RP, Nolan GP, Benchimol S (1999) Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts. Mol Cell Biol 19: 2373-2379.
  • Vesuna F, Winnard P Jr, Raman V, Glackin C (2006) Twist overexpression promotes chromosomal instability in the breast cancer cell line MCF-7. Cancer Genet Cytogenet 167: 189-191.
  • Wang R, Lu YJ, Fisher C, Bridge JA, Shipley J (2001) Characterization of chromosome aberrations associated with soft-tissue leiomyosarcomas by twenty-four-color karyotyping and comparative genomic hybridization analysis. Genes Chr Cancer 31: 54-64.
  • Wark L, Novak D, Sabbaghian N, Amrein L, Jangamreddy JR, Cheang M, Pouchet C, Aloyz R, Foulkes WD, Mai S, Tischkowitz M (2013) Heterozygous mutations in the PALB2 hereditary breast cancer predisposition gene impact on the three-dimensional nuclear organization of patient-derived cell lines. Genes Chromosomes Cancer 52:480-494.
  • Watson MB, Bahia H, Ashman JN, Berrieman HK, Drew P, Lind MJ, Greenman J, Cawkwell L (2004) Chromosomal alterations in breast cancer revealed by multicolour fluorescence in situ hybridization. Int J Oncol 25:277-283.
  • Weier HU, Tuton TB, Ito Y, Chu LW, Lu CM, Baumgartner A, Zitzelsberger HF, Weier JF (2006) Molecular cytogenetic characterization of chromosome 9-derived material in a human thyroid cancer cell line. Cytogenet Genome Res 114:284-291.
  • Weier HU, Ito Y, Kwan J, Smida J, Weier JF, Hieber L, Lu CM, Lehmann L, Wang M, Kassabian HJ, Zeng H, O'Brien B (2011) Delineating Chromosomal Breakpoints in Radiation-Induced Papillary Thyroid Cancer. Genes (Basel) 2:397-419.
  • Weise A, Liehr T, Efferth T, Kuechler A, Gebhart E (2002) Comparative M-FISH and CGH analyses in sensitive and drug-resistant human T-cell acute leukemia cell lines. Cytogenet Genome Res 98:118-125
  • White JS, Becker RL, McLean IW, Director-Myska AE, Nath J (2006) Molecular cytogenetic evaluation of 10 uveal melanoma cell lines. Cancer Genet Cytogenet 168:11-21.
  • Williams SV, Adams J, Coulter J, Summersgill BM, Shipley J, Knowles MA (2005) Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro. Genes Chromosomes Cancer 43: 315-328.
  • Winnard P Jr, Glackin C, Raman V (2006) Stable integration of an empty vector in MCF-7 cells greatly alters the karyotype. Cancer Genet Cytogenet 164:174-176.
  • Wong N, Hui ABY, Fan B, Lo KW, Pang E, Leung S-F, Huang DP, Johnson PJ (2003) Molecular cytogenetic characterization of nasopharyngal carcinoma cell lines and xenografts by comparative genomic hybridization and spectral karyotyping. Cancer Genet Cytogenet 140: 124-132
  • Wu YP, Yang YL, Yang GZ, Wang XY, Luo ML, Zhang Y, Feng YB, Xu X, Han YL, Cai Y, Zhan QM, Wu M, Dong JT, Wang MR (2006) Identification of chromosome aberrations in esophageal cancer cell line KYSE180 by multicolor fluorescence in situ hybridization. Cancer Genet Cytogenet 170:102-107.
  • Xie D, Jauch A, Miller CW, Bartram CR, Koeffler HP (2002) Discovery of over-expressed genes and genetic alterations in breast cancer cells using a combination of suppression subtractive hybridization, multiplex FISH and comparative genomic hybridization. Int J Oncol 21: 499-507.
  • Xu J, Chambers AF, Tuck AB, Rodenhiser DI (2008) Molecular cytogenetic characterization of human breast cancer cell line MDA-MB-468 and its variant 468LN, which displays aggressive lymphatic metastasis. Cancer Genet Cytogenet 181:1-7.
  • Xu J, Souter LH, Chambers AF, Rodenhiser DI, Tuck AB (2008) Distinct karyotypes in three breast cancer cell lines --21PTCi, 21NTCi, and 21MT-1 --derived from the same patient and representing different stages of tumor progression. Cancer Genet Cytogenet 186:33-40.
  • Yamashita Y, Nishida K, Okuda T, Nomura K, Matsumoto Y, Mitsufuji S, Horiike S, Hata H, Sakakura C, Hagiwara A, Yamagishi H, Taniwaki M (2005) Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping. World J Gastroenterol 11:5129-5135
  • Yang J, Qin LX, Li Y, Ye SL, Liu YK, Gao DM, Chen J, Tang ZY (2005) Molecular cytogenetic characteristics of the human hepatocellular carcinoma cell line HCCLM3 with high metastatic potential: comparative genomic hybridization and multiplex fluorescence in situ hybridization. Cancer Genet Cytogenet 158: 180-183
  • Yang Y, Padilla-Nash HM, Vira MA, Abu-Asab MS, Val D, Worrell R, Tsokos M, Merino MJ, Pavlovich CP, Ried T, Linehan WM, Vocke CD (2008) The UOK 257 cell line: a novel model for studies of the human Birt-Hogg-Dubé gene pathway. Cancer Genet Cytogenet 180:100-109.
  • Yang YC, Wang SW, Wu IC, Chang CC, Huang YL, Lee OK, Chang JG, Chen A, Kuo FC, Wang WM, Wu DC (2009) A tumorigenic homeobox (HOX) gene expressing human gastric cell line derived from putative gastric stem cell. Eur J Gastroenterol Hepatol 21:1016-1023.
  • Yang Y, Valera VA, Padilla-Nash HM, Sourbier C, Vocke CD, Vira MA, Abu-Asab MS, Bratslavsky G, Tsokos M, Merino MJ, Pinto PA, Srinivasan R, Ried T, Neckers L, Linehan WM (2010) UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer. Cancer Genet Cytogenet 196:45-55.
  • Yen CC, Chen YJ, Lu KH, Hsia JY, Chen JT, Hu CP, Chen PM, Liu JH, Chiou TJ, Wang WS, Yang MH, Chao TC, Lin CH (2003) Genotypic analysis of esophageal squamous cell carcinoma by molecular cytogenetics and real-time quantitative polymerase chain reaction. Int J Oncol 23:871-881
  • Yu XY, Heller A, Liehr T, Aurelian J (2001) Expression analysis and chromosome location of a novel gene (H11) associated with the growth of human melanoma cells. Int J Oncol 18: 905-911.
  • Zahnreich S, Krunic D, Melnikova L, Szejka A, Drossel B, Sabatier L, Durante M, Ritter S, Fournier C. (2012) Duplicated chromosomal fragments stabilize shortened telomeres in normal human IMR-90 cells before transition to senescence. J Cell Physiol 227:1932-1940.
  • Zanazzi C, Hersmus R, Veltman IM, Gillis AJ, van Drunen E, Beverloo HB, Hegmans JP, Verweij M, Lambrecht BN, Oosterhuis JW, Looijenga LH (2007) Gene expression profiling and gene copy-number changes in malignant mesothelioma cell lines. Genes Chromosomes Cancer 46:895-908.
  • Zhang A, Zheng C, Hou M, Lindvall C, Wallin KL, Angstrom T, Yang X, Hellstrom AC, Blennow E, Bjorkholm M, Zetterberg A, Gruber A, Xu D (2002) Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas. Genes Chromosomes Cancer 34: 269-275.
  • Zhang H, Tsao SW, Jin C, Strombeck B, Yuen PW, Kwong YL, Jin Y (2004) Sequential cytogenetic and molecular cytogenetic characterization of an SV40T-immortalized nasopharyngeal cell line transformed by Epstein-Barr virus latent membrane protein-1 gene. Cancer Genet Cytogenet 150: 144-152.
  • Zhang H, Jin Y, Chen X, Jin C, Law S, Tsao SW, Kwong YL (2006) Cytogenetic aberrations in immortalization of esophageal epithelial cells. Cancer Genet Cytogenet 165: 25-35.
  • Zhou B, Mo X, Liu X, Qiu W, Yen Y (2001) Human ribonucleotide reductase M2 subunit gene amplification and transcriptional regulation in a homogeneous staining chromosome region responsible for the mechanism of drug resistance. Cytogenet Cell Genet 95: 34-42.
  • Zimonjic DB, Zhou X, Lee JS, Ullmannova-Benson V, Tripathi V, Thorgeirsson SS, Popescu NC (2009) Acquired genetic and functional alterations associated with transforming growth factor beta type I resistance in Hep3B human hepatocellular carcinoma cell line. J Cell Mol Med 13: 3985-3992.
  • Zitzelsberger H, Lehmann L, Hieber L, Weier HU, Janish C, Fung J, Negele T, Spelsberg F, Lengfelder E, Demidchik EP, Salassidis K, Kellerer AM, Werner M, Bauchinger M (1999) Cytogenetic changes in radiation-induced tumors of the thyroid. Cancer Res 59: 135-140.