Specific PATIENTINFORMATION for sSMC(16) - part 1
Specific PATIENTINFORMATION for sSMC(16) - part 2

clinical symptoms

In general 70% of sSMC carriers are clinically normal. The figures listed above
are based on the bias, that mainly clinically aberrant cases are studied and reported in literature!

UPD (uniparental disomy) cases:

UPD(16)mat

UPD(16)pat

UPD(16)mat or pat

the probably non-dosage sensitive pericentric region of chromosome 16
schematic cytogenetic depiction	short (= p-) arm heterochromatin long (= q-) arm p13 p12 p11.2 cen q11.2 q12 q13 q21 q22 nono clinical signs clinical signs
schematic molecular- cytogenetic depiction	Data is converted between genome versions by UCSC browser! Note the changes defined there for centromere-sizes; due to that and due to 'new insertions and deletions', positions are not always seeming logical comparing different versions listed  genomic version critical region p-arm uncritical region p-arm centromere uncritical region q-arm critical region q-arm NCBI 36/ hg18 ? {55} 28.73 34.40 - 45.50 46.02 46.16 GRCh 37/ hg19 ? {55} 28.82 +++ 34.60 - 47.00 47.60 47.64 GRCh 38/ hg38 ? {55} 28.81 35.30 - 47.00 47.43 47.57   Positions given in megabasepair (Mbp) acc. to cases marked as *** +++ - acc to {60} CNVs in the region chr156[hg19]:21475060-29284077 or 30199854  may lead to DD