web-presence: https://cs-tl.de/Start.html
Created by Dr. Thomas Liehr (PhD),
affiliation: Institute of Human Genetics, 07740 Jena, Germany;
e-mail: Thomas.Liehr@med.uni-jena.de or LiehrT@web.de
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a About Pukas  |
ChromosOmics was introduced by Prof. Uwe Claussen in 2005.
Per his definition "the term "chromosomics" is introduced to draw attention to the three-dimensional morphological changes in chromosomes that are essential elements in gene regulation. Chromosomics deals with the plasticity of chromosomes in relation to the three-dimensional positions of genes, which affect cell function in a developmental and tissue-specific manner during the cell cycle. It also deals with species-specific differences in the architecture of chromosomes, which has been overlooked in the past. Chromosomics includes research into chromatin-modification-mediated changes in the architecture of chromosomes, which may influence the functions and life-spans of cells, tissues, organs and individuals. It also addresses the occurrence and prevalence of chromosomal gaps and breaks."
ChromosOmics was highlighted again in 2019 (see here) and Prof. Claussen was honored by a symposium in 2019 (see here).
References
- Claussen
U. Chromosomics. Cytogenet Genome Res. 2005;
111:101-106.
- Liehr
T. Expert knowledge on human genetic
counselling and chromosomics are necessary for sound
genetic laboratory diagnostics. Mol Exp Biol Med 2017,
1: 1-3
- Deakin
JE, Potter S. Marsupial chromosomics: bridging
the gap between genomes and chromosomes. Reprod Fertil
Dev. 2019 Jan 11. doi: 10.1071/RD18201. [Epub ahead of
print]
- Deakin JE, Potter S, O'Neill R, Ruiz-Herrera A, Cioffi MB, Eldridge MDB, Fukui K, Marshall Graves JA, Griffin D, Grutzner F, KratochvÃl L, Miura I, Rovatsos M, Srikulnath K, Wapstra E, Ezaz T. Chromosomics: Bridging the gap between genomes and chromosomes. Genes (Basel) 2019; 10: E627.
- Liehr
T. From human cytogenetics to human
chromosomics. Int J Mol Sci. 2019; 20: E826.
- Liehr
T. Molecular cytogenetics in the era of
chromosomics and cytogenomic approaches. Front Genet
2021, 12: 720507
- Liehr
T. A Definition for Cytogenomics – also may be
called chromosomics. In: Liehr T. Cytogenomics.
Academic Press, 2021, pp 1-7.
link helpful for
diagnostics
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