ChromosOmics - About the Author

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Thomas Liehr (2019)

web-presence: https://cs-tl.de/Start.html



Created by Dr. Thomas Liehr (PhD),

affiliation: Institute of Human Genetics, 07740 Jena, Germany;
e-mail: Thomas.Liehr@med.uni-jena.de
or LiehrT@web.de

Publications of Thomas Liehr
Book Chapters



2024
120



T Liehr.
Challenges and ethical issues surrounding noninvasive prenatal screening (NIPS).

In: Non-invasive prenatal screening (NIPS) in clinical practice. RA Rather, SC Saha (eds.)
Springer
pp 241-257.
2024
ISBN 978-9819764013 
119



A Weise, T Liehr.
Advanced genomic approaches in noninvasive prenatal screening: The road from conventional karyotyping to next-generation sequencing.
In: see above
 pp 97-104.

118



T Liehr.
FISH-Banding for Characterization of Simple and Complex Chromosomal Rearrangements in Cancer.

In: JC Ye, H Heng (eds.)
 Cancer Cytogenetics and Cytogenomics

Springer
pp 205-211.
2024
ISBN 978-1071639450
117



T LiehrC Andersen, S Wynn, A Pelling.
Ring chromosomes from patients’ perspective.
In: P Li, T Liehr (ed.)
Human ring chromosomes.
A practical guide for clinicians and families.

 Springer
pp 363-401.

2024
ISBN 978-3031475290
116

T Liehr.
Small supernumerary ring chromosomes.
In: see above
pp 353-362.

115

T Liehr.
Ring chromosome 7.

In: see above
pp 139-150.

114

Q Hu, D Ma, P Li, T Liehr.
Genetic databases and online ring chromosome registry.
In: see above

pp 31-42.

113




P Li, T Liehr.
Historical perspective of human ring chromosomes.
In: see above

pp 3-16.



2023

112


T Liehr
FISH—and CRISPR/CAS9. In: T Liehr (Ed.) Cytogenetics and Molecular Cytogenetics.
1st Edition
Taylor and Francis
pp 353-356.
2023

eBook ISBN 9781003223658

111




T Liehr
FISH—On fibers
In: see above
 pp 207-210

110




T Liehr
FISH—in three dimensions—3D-FISH
In: see above
 pp 201-206

109




T Liehr
FISH—Detection of individual radio sensitivity
In: see above
 pp 163-170

108




T Liehr
FISH—Centromere- and heterochromatin-specific multicolor probe sets
In: see above
 pp 157-162

107




T Liehr
Multicolor-FISH—Methods and applications
In: see above
 pp 151-156

106




IP Ribeiro, E Matoso, JB Melo, A Jardim, T Liehr, IM Carreira
FISH—Characterization of chromosomal alterations, recombination, and outcomes after segregation
In: see above
 pp 121-150 

105




T Liehr
FISH—in spontaneously aborted products of conceptions.
In: see above
 pp 117-120 

104




M Rincic, T Liehr
FISH—in human sperm and infertility.
In: see above
 pp 111-116

103




T Liehr
FISH—in tissues.
In: see above
 pp 105-110

102




T Liehr
FISH—An overview.
In: see above
 pp 35-42

101




T Liehr
Cytogenetics and chromosomics.
In: see above
 pp 1-6




2022

100

A Weise, T Liehr
Cytogenetics.
In: Reference Collection in Life Science.
Elsevier,
ISBN 9780128096338,
https://doi.org/10.1016/B978-0-12-822563-9.00054-8.

2022

99



T Liehr
Predictive genetic testing in early human reproduction.
In: Predictive Medicine Evolution.
Ed. V.S. Baranov
Eco Vector

St. Petersburg
pp 286-296
2022

ISBN 9785907201675

98






L Delmonico, R Tavares Silvestre, M Chantre-Justino, K Andrade Dormund, G Brito Ribeiro, MH Faria Ornellas, T Liehr, G Alves, C Lage
Measuring telomere length: A timeline review on the state-of art techniques.
In: N Rezaei (ed.) Encyclopedia of Infection and Immunity (4)
pp 259-275
2022

ISBN 9780128187319




2021

97




T Liehr
ПРОГНОСТИЧЕСКОЕ ГЕНЕТИЧЕСКОЕ ТЕСТИРОВАНИЕ НА РАННИХ СТАДИЯХ РЕПРОДУКЦИИ (Predictive genetic tests in early stades of reproduction).
In: V.S. Baranvov. ЭВОЛЮЦИЯ ПРЕДИКТИВНОЙ МЕДИЦИНЫ (Evolution of Predictive Medicine).
ZKO-VECTOR
St. Petersburg
pp 282-295
2021

ISBN 9785907201484

96




T Liehr
Repetitive elements, heteromorphisms and copy number variants.

In: T Liehr. Cytogenomics.   
pp 373-388
Academic Press
2021

ISBN: 9780128235799


95




A Weise, T Liehr
Interchromosomal interactions with meaning for disease.
In: see above
pp 349-356

94




T Liehr
Nuclear architecture.
In: see above
pp 297-305

93




A Weise, T Liehr
Molecular karyotyping.
In: see above
pp 72-85

92



T Liehr
Molecular cytogenetics.
In: see above
pp 35-45

91



A Weise, T Liehr
Cytogenetics.
In: see above
pp 25-34

90



T Liehr
Overview of yet available approaches used in cytogenomics.
In: see above
pp 11-24

89



T Liehr
  A Definition for Cytogenomics – also may be called Chromosomics.
In: see above
pp 1-7



2020

88




T Liehr
Chromosome architecture studied by high-resolution FISH banding in three-dimensionally preserved human interphase nuclei.
In: Human Interphase Chromosomes
Biomedical Aspects.
Eds:
I Iourov, S Vorsanova, Y Yurov
pp 147-155
Springer
2020

ISBN 9781461465577




2019

87



A Weise, T Liehr
Rapid Prenatal Aneuploidy Screening by Fluorescence In Situ Hybridization (FISH).
In: Methods Mol Biol. Series on Prenatal Diagnosis
1885:129-137
Springer
2019

ISBN: 978-1493988877



2018

86




T Liehr, M Ziegler, S Löhmer, A Weise
Assessing skewed X-chromosome inactivation.
In: Current protocols of Human Genetics
98: e66
Wiley
2018

85




 T Liehr
Leihmutterschaft und Genetik.
In: Leihmutterschaft und Familie; Impulse aus Recht, Theologie und Medizin.
 Ed: E Schramm, M Wermke. 
pp 183-190
Springer
2018

ISBN 978-3662562512
84



T Liehr
Chromothripsis detectable in small supernumerary marker chromosomes (sSMC) using fluorescence in situ hybridization (FISH).
 In: Chromothripsis; series Methods in Molecular Biology
pp 79-84
Springer
2018

ISBN: 978-1493977796


83




a
T Liehr

Characterization of RB1 deletions in interphase and metaphase by molecular cytogenetics exemplified in chronic lymphatic leukemia.
In: The Retinoblastoma Protein; series Methods in Molecular Biology
pp 1-6
Springer
2018

ISBN: 978-1493975655




2017

82


A Weise, T Liehr
Background.
In: Fluorescence in situ Hybridization (FISH) – Application Guide, 2nd Ed.
Springer
pp 1-14
Ed.: T Liehr
2017

ISBN: 978-3662529577
81

T Liehr
Classification of FISH probes.
In: see above
pp 43-47

80
T Liehr
Commercial FISH probes.
In: see above
pp 49-61

79
N Kosyakova, T Liehr, AB Hamid Al-Rikabi
FISH-microdissection.
In: see above
pp 81-99

78
T Liehr
Homemade locus-specific FISH probes: bacterial artificial chromosomes.
In: see above
pp 101-106

77
T Liehr, K Kreskowski, M Ziegler, K Piaszinski, K Rittscher
The standard FISH procedure.
In: see above
pp 109-118

76
A Weise, T Liehr
Microwave treatment for better FISH results in a shorter time.
In: see above
pp 119-122

75
G Joksic, I Joksic, J Filipović, T Liehr
 Telomere length measurement by FISH.
In: see above
pp 147-152

74
A Weise, T Liehr
Pre- and postnatal diagnostics and research on peripheral blood, bone marrow chorion, amniocytes, and fibroblasts.
In: see above
pp 171-180

73
T Liehr, M Ziegler
Application of FISH to previously GTG-banded and/or embedded cytogenetic slides.
In: see above
pp 181-184

72
A Weise, M Ziegler, T Liehr
FISH in uncultivated amniocytes.
In: see above
pp 185-188

71
E Alhourani, MAK Othman, SS Hussein Azawi, T Liehr
Tumorcytogenetic diagnostics and research on blood and bone marrow smears or effusions.
In: see above
pp 189-194

70
T Liehr, N Kosyakova
Characterization of mosaicism in different easy-to-acquire body tissues such as buccal smears, skin abrasions, hair root cells or urine.
In: see above
pp 195-200

69
T Liehr
Characterization of archived formalin-fixed/paraffin-embedded or cryofixed tissue, including nucleus extraction.
In: see above
pp 201-208

68
T Liehr
Two- to three-color FISH.
In: see above
pp 227-232

67
T Liehr, N Kosyakova
Multiplex FISH and spectral karyotyping.
In: see above
pp 233-239

66
T Liehr
FISH banding techniques.
In: see above
pp 241-247

65
T Liehr, A Weise, N Kosyakova.
cenM-FISH approaches.
In: see above
pp 249-255

64
T Liehr, N Kosyakova, A Weise, AB Hamid Al-Rikabi
Heterochromatin directed M-FISH (HCM-FISH).
In: see above
pp 257-259

63
A Weise, T Liehr
Subtelomeric and/or subcentromeric probe sets.
In: see above
pp 261-269

62
T Liehr
Bar-coding is back.
In: see above
pp 271-274

61
A Weise, T Liehr
Parental origin determination FISH: pod-FISH.
In: see above
pp 295-300

60
E Klein, T Liehr
CENP-antibodies used additionally to FISH.
In: see above
pp 347-351

59
T Liehr, S Hauke
Interphase FISH in diagnostics.
In: see above
pp 355-359

58
G Hovhannisyan, T Harutyunyan, T Liehr
Micronucleus FISH.
In: see above
pp 379-383

57
T Liehr, N Kosyakova
Three-dimensional interphase analysis enabled by suspension FISH.
In: see above
pp 385-392

56
T Liehr
FISH on insect cells transfected with heterologous DNA.
In: see above
pp 473-476

55
T Liehr
Comparative genomic hybridization (CGH) and microdissection-based CGH (micro-CGH).
In: see above
pp 561-565


54




T Liehr, MAK Othman, K Rittscher
Multi-color karyotyping and FISH-banding (MCB/mBAND).
In: Cancer Cytogenetics: Methods and Protocols
pp 181-187
Springer
2017

ISBN: 978-1493982783



2015

53




F Santiago, T Liehr
Genetics monitoring of gas stations workers.
In: The health and environmental threats related to gas stations.
GA Brown (Ed.)
pp 69-77
Lambert Academic Publishing
2015

ISBN: 978-3659814457

52



IE Gomaa, S Bhatt, T Liehr, M Bakr, TA El-Tayeb
 A study on biological applicaton of CO/Ag nanoparticles cytotoxicity and genotoxicity.
In: Nanomaterials and Nanotechnology for Composites Design, Simulation and Applications.
Eds: A. K. Haghi, S Thomas, A Pourhashemi, A Hamrang, E Klodzinska
 pp 139–153
Apple Academic Press
2015

ISBN: 978-1-77188-065-7

51



IE Gomaa, S Bhatt, T Liehr, M Bakr, TA El-Tayeb
AG and CO/AG nanoparticles cytotoxicity and genotoxicity study on HEP-2 and blood lymphocyte cells.
In: Chemical Technology, Key Developments in Applied Chemistry, Biochemistry and Materials Science
Eds: N Guarrotxena, GE Zaikov, AK Haghi
pp 13-30
Apple Academic Press
2015

ISBN: 978-1-77188-051-0

50





A Weise, MA Othman, S Bhatt, S Löhmer, T Liehr
2015
Application of BAC-Probes to visualize copy number variants (CNVs).
Ed. K Narayanan
In: Bacterial Artificial Chromosomes, 2. Ed.
Methods Mol Biol 1227:299-307
Springer
2015

ISBN: 978-1493954308
 
49
K Mrasek, K Wilhelm, LG Quintana, L Theuss, T Liehr, A Leskovac, J Filipovic, G Joksic, I Joksic, A Weise.
BAC-probes applied for characterization of fragile sites (FS).
In: see above
289-298

48
AB Hamid, X Fan, N Kosyakova, G Radhakrishnan, T Liehr, T Karamysheva
New BAC probe set to narrow down chromosomal breakpoints in small and large derivative chromosomes, especially suited for mosaic conditions.
In: see above
279-287



2014

47



T Liehr
Fluorescence in situ Hybridization (FISH): When and how to do? How to interpret? How to counsel?
In: Genetics in Clinical Practice: Symptoms, Diagnosis and Therapy.
Eds.: J. Sheth and F. Sheth.
pp 73-92
Jaypee Brothers Medical Publishers
2014

ISBN 978-9351521532.




2013

46




IY Iourov, T Liehr, SG Vorsanova, YB Yurov
Interphase chromosome-specific multicolor banding.
In: Human Interphase Chromosomes - Biomedical Aspects.
Ed: YB Yurov, SG Vorsanova, IY Iourov
pp 161-169
Springer
2013

ISBN: 978-1489985392

45
T Liehr, H Mkrtchyan, M Manvelyan, T Karamysheva, E Klein, S Bhatt
Chromosome architecture studied by high-resolution FISH-banding in three dimensionally preserved human interphase nuclei.
In: see above
pp 171-178



2010

44




T Liehr, A Weise, S Hinreiner, H Mkrtchyan, K Mrasek, N Kosyakova
Characterization of chromosomal rearrangements using multicolor-banding (MCB/m-band).
In Fluorescence in situ Hybridization (FISH): Protocols and Applications (Methods in Molecular Biology)
Ed JM Bridger and EV Volpi
659:231-238
Springer
2010

ISBN: 978-1607617884

43
A Weise, M Gross, S Hinreiner, V Witthuhn, H Mkrtchyan, T Liehr
POD-FISH, a new technique for parental origin determination based on copy number variation polymorphism.
In: see above
659:291-298


42




T Liehr

Fluorescence in situ hybridization (FISH) - quality issues in molecular cytogenetics.
In: Quality Issues in Clinical Genetic Services.
U Kristoffersson, J Schmidtke, JJ Cassiman (Eds.),
pp 315-320
Springer
2010

ISBN 9-78-90-481-3918-7



2009

41




T Liehr
F Pellestor
Molecular cytogenetics: The standard FISH and PRINS procedure.
In:  Fluorescence in situ Hybridization (FISH) – Application Guide, 2nd Ed.
pp 23-34
Springer, Berlin
2009

ISBN: 978-3540705802
40

A Weise, K Mrasek, N Kosyakova, H Mkrtchyan, M Gross, V Klaschka, T Liehr.
ISH probes derived from BACs, including microwave treatment for better FISH-results.
In: see above
pp 53-60

39

A Weise, T Liehr
Pre- and postnatal diagnostics and research on peripheral blood, chorion, amniocytes, and fibroblasts.
In: see above
pp 113-122

38

A Heller, M Gross, V Witthuhn, K Behr, S Hinreiner, H Mkrtchyan, T Liehr
Tumorcytogenetic diagnostics and research on uncultured blood or bone marrow and smears.
In: see above
pp 131-136

37

T Liehr, E Gebhart
Application of FISH on archival cytogenetic slides.
In: see above
pp 137-140

36

K Mrasek, A Weise, M Gross, H Mkrtchyan, T Liehr
Characterization of mosaicism in various easy-to acquire body tissues such as buccal smears, hair root cells or urine.
In: see above
pp 141-146

35

T Liehr, M Manvelyan
Characterization of archived formalin-fixed/paraffin-embedded or cryofixed tissue, including nucleus extraction.
In: see above
pp 147-156

34

T Liehr, K Mrasek, N Kosyakova, H Mkrtchyan, J Melo, A Polityko, L Brecevic
Multiplex FISH and spectral karyotyping.
In: see above
pp 175-182

33

T Liehr, K Mrasek, N Kosyakova, H Nelle, V Trifonov, M Manvelyan, A Weise
FISH-banding techniques.
In: see above
pp 243-250

32
N Kosyakova, A Weise, K Mrasek, H Mkrtchyan, V Klaschka, E Ewers, D Reich, N Rüdiger, T Liehr
cenM-FISH approaches.
In: see above
pp 251-260

31

A Weise, K Mrasek, M Gross, V Klaschka, T Liehr
Subtelomeric and/or subcentromeric probe sets.
In: see above
pp 261-168

30

A Weise, K Mrasek, H Mkrtchyan, M Gross, S Hinreiner, T Liehr
Parental origin determination FISH: pod-FISH.
In: see above
pp 293-300

29
F Hunstig, M Manvelyan, S Bhatt, U Steinhaeuser, T Liehr
Three-dimensional interphase analysis enabled by suspension FISH.
In: see above
pp 313-322

28
T Liehr
FISH on insect cells transfected with heterologous DNA: a single-cell-directed approach.
In: see above
pp 361-364

27
A Heller, T Liehr
Micro CGH: Microdissection-based comparative genomic hybridization.
In: see above
pp  411-420

26
T Liehr, A Weise
FISH and chips on the internet.
In: see above
pp 441-44



2008

25




T Liehr
Characterization of prenatally assessed de novo small supernumerary marker chromosomes (sSMC) by molecular cytogenetics.
In: Methods Mol Biol. series on Prenatal Diagnosis; Vol 444
pp 27-38
Humana Press
2008

ISBN: 978-1-58829-803-4


24
A Weise, T Liehr
Rapid Prenatal Aneuploidy Screening by Fluorescence In Situ Hybridization (FISH). In: see above
 pp 39-48



2007

23





A Weise, T Liehr
Untersuchungen zur Karyotypevolution der großen Menschenaffen.
In: Beiträge zur Archäozoologie und prähistorischen Anthropologie, Band VI.
Ed: N. Benecke
pp 232-236
2007

ISBN 978-3-937517-81-0




2006

22




T Liehr

Application of YACs in fluorescence in situ hybridization (FISH).
In: Methods in Molecular Biology YAC protocols,m 2. ed
Ed A MacKenzie,
pp 175-186
Humana Pres
2006

ISBN 1-588296121



2004

21








T Liehr

FISH-Banding Methods and their Clinical Applications.
 In: Encyclopedia of Diagnostic Genomics and Proteomics
Eds: J Fuchs; M Podda
pp 457-460
Taylor & Francis Inc

2004

ISBN: 0824747941 and 0824755642

20


T Liehr

FISH - Centromere specific multicolor FISH (CenM-FISH) – a versatile tool for characterization of small supernumerary marker chromosomes.
 In: see above
pp 468-470

19
A Kuechler, T Liehr
FISH - Detection of individual radiosensitivity.
 In: see above
pp 474-477



2002

18


T Liehr, A Nietzel, M Rocchi, A Heller, H Starke, U Claussen, F v Eggeling
Centromere-specific multicolor-FISH (cenM-FISH) followed by analysis for uniparental disomy - a useful tool in prenatal diagnosis.
In: Early prenatal diagnosis, fetal cells and DNA in the mother - present state and perpectives.
Eds: M Macek, DW Bianchi, H Chuckle
pp 293-300
The Karolinum Press
2002
ISBN: 80-24603977 

17




T Liehr, B Rautenstrauss
FISH analysis of interphase nuclei extracted from paraffin-embedded tissue.
In: The Ultimate FISHing Guide -sample preparation and application protocols.
European Edition
 pp 15-16
Q-Biogene
2002

ISBN: n.a.  

16



T Liehr
, U Claussen
FISH on chromosome preparations of peripheral blood.
In: T Liehr, B Rautenstrauss
FISH-Technology, Springer-labmanual
pp 73-81
Springer, Berlin
2002

 ISBN: 3-54067276118.

15
T Liehr
FISH on uncultured blood or bone marrow. In: see above
 pp 82-89

14
 T Liehr
FISH on blood or bone marrow smears.
In: see above
pp 90-96

13
T Liehr
FISH on hair root cells.
In: see above
pp 109-114

12
T Liehr
Nucleus extraction from formalinfixed/paraffin embedded tissue.
In: see above
 pp 162-170

11
B Rautenstrauss, T Liehr
Nucleus extraction from cryofixed tissue.
In: see above
 pp 176-184

10
T Liehr
FISH on insect cells transfected with heterologous DNA.
In: see above
 pp 323-328

9
A Nietzel, A Heller, H Starke, T Liehr
 Centromere-specific multicolor-FISH (cenM-FISH).
In: see above
 pp 425-431

8
T Liehr
Internet sites related to cytogenetics and molecular cytogenetics.
In: see above
 pp 485-486



2000

7




T Liehr

Cytogenetics of ovarian cancer: Technical overview.
In: Methods in Molecular Medicine: Ovarian Cancer – Methods and Protocols,
Ed.: J.M.S. Bartlett
pp 207-213
Humana Press
 2000

ISBN: 0-896035832
  
6
T Liehr
Interphase cytogenetics in frozen ovarian tumor tissue.
In: see above
pp 215-221

5


S Neubauer, T Liehr
Interphase cytogenetics in paraffin embedded ovarian tissue.
In: see above
pp 223-228



1997

4




S Neubauer, S Birkenhake, I Schneider, T Liehr, E Gebhart, R Fietkau, R Sauer
DNA-Reparatur an Tumor- und Normalgewebe - Erste Ergebnisse der Bestimmung mit Hilfe des Comet-Assays.
In: Experimentelle Strahlentherapie und klinische Strahlenbiologie, Band 6
pp 175-179
Ed.: Beck-Bornholdt H-P, Baumann M
 1997

ISBN: n.a.



1996

3




KD Bathke, T Liehr, AB Ekici, H Grehl, D Heuss, B Rautenstrauss, B Neundörfer
Das klinische Bild einer hereditären motosensorischen Neuropathie Typ I (CMT1) bei Patienten mit einer HNPP-Deletion auf Chromosom 17p11.2 und einer PMP22-Punktmutation.
In: Jahrbuch der neuromuskulären Erkrankungen
Acris
1996

ISBN: 3-89075-112-1

2




T Liehr, B Rautenstrauss
FISH analysis of interphase nuclei extracted from paraffin-embedded tissue.
In: The Ultimate FISHing Guide - sample preparation and application protocols.
pp E4-E6
ONCOR
1996

ISBN n.a.





1994

1






H Grehl, B Rautenstrauss, T Liehr, A Ekici, H Finder, K D Bathke, B Neundörfer
Nachweis der chromosomalen 17p11.2 Duplikation bei HMSN 1A (Hereditäre motorische sensible Neuropathie) und der korrespondierenden Deletion bei HNPP (tomakolöse Neuropathie) durch Southern-Hybridisierung und Fluoreszenz-in-situ-Hybridisierung.
In: Verhandlungen der deutschen Gesellschaft für Neurologie Bd. 8
pp 441-443
Springer
1994

ISBN n.a.






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