ChromosOmics - Database
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                                                     - CHROMOSOME  15  -                                                   


Heterochromatic

- centromeric
- other heterochromatic variants
Euchromatic

- euchromatic deletions
- euchromatic duplications
References


Heterochromatic - (peri)centromeric variants
for further NOR-region variants principally possible but not specified for13-15 or 21-22 yet see acro-chrs.


case no.

(molecular) cytogenetic result

clinical symptoms

reference
15-
p13-p12/
1-1 to several

dup(15)(p13p12)
none
{1, page 42}
15-
p13+/
1-1 to several

der(15)(p13amp)
none
{1}
15-
p13-/
1-1 to few

del(15)(p13) or del(15)(p13p13)
none
{1, pages 51-52}
15-
p12+/
1-1 to 1-3

der(15)(p12amp)
NOR

none
{1; 0-65363}
15-
p12-/
1-1 to few

del(15)(p12) or del(15)(p12p12)
NOR

none
{1, pages 51-52}
15-
p11.2+/
1-1 to several

der(15)(p11.2amp)
none
{1}
15-
p11.2-/
1-1 to few

del(15)(p11.2) or del(15)(p11.2p11.2)
none
{1, pages 51-52}
15-
cen+/

1-1 to many
15cen+
D15Z3 in 15q11.1
(can also be in D15Z4 in 15p11.1)

none
{1, pages 72-73}
15-
cen-/
1-1 to few

15cen-
D15Z3 in 15q11.1
(can also be in D15Z4 in 15p11.1)

none
{1, pages 72-73}
15-
inv/
1-1

inv(15)(p12p13)
none
{1, Color Plate 1, VI}
15-
inv(dup)/
2-1

der(15)(:p11.1→p13::p13→qter)
none
{0}

Heterochromatic - other heterochromatic variants

case no.
(molecular) cytogenetic result
clinical symptoms
reference
15-
HHM-owncep/
1-1
D15Z1 was inserted in
13, 14, 21, 22;
has already been seen on 2 add. acrocentrics simultanously.
Even though being present in >10% in normal population Reference {97} suggests a correlations of this variant with aneuploidy in offspring
none
{1}
15-
HHM-owncep-
15p11.2/

1-1
der(15)(:p11.2->p13::p13->qter)
none
{0 - 58145}
15-
HHM-amp-
15p11.2/

1-1
D15Z1 was amplfied and band 15p11.2 thus got the size of short arm of chromosome 17
none
{0} provided by Drs. S. Singer, U. Mau-Holzmann and D. Pflumm, Tübingen, Germany
15-
HHM-13p11.1q11-
21p11.1q11.1/
1-1

der(15)t(13/21;15)(p11.1;p11.1)
D13/21Z1 signal on one #15

none
{1, page 81; 8, 49}
15-
HHM-
acro/

1-1
der(15)t(15;acro)(q26.3;p11.2)

none
{0}
15-
HHM-
acro/

2-1
der(15)(15pter->15q1?3::acrop1?->acrop1?::15q1?3->15qter) 

none
{0 - 56848}
15-
HHM-
acro/

3-1
der(15)(15pter->15q12::15q13->NORamp::15q13->NORamp:
:15q13->NORamp::15q13->NORamp:
:15q13->NORamp::15q13->NORamp::15q12->15qter) 

none
{0 - 63602}
15-
HHM-
Yq12/
1-1 to 1-many

der(15)t(Y;15)(q12;p11.2)
none
{1, page 47; 3; 4; 70}
15-
HHM-
Yq12/
2-1

ins(15;Y)(q10;q12q12)
none
{1, page 83; 61}

Euchromatic deletions

case no.
(molecular) cytogenetic result
clinical symptoms
reference
15-
EHM-del
q11q12/

1-1
del(15)(q11q12)
RP11-138C5
22.676624-23.226623 Mb

mild to moderate
{1- 16861; 113}

Euchromatic duplications

case no.
(molecular) cytogenetic result
clinical symptoms
reference
15-
EHM-dup
pterq11.2/
1-1 to 1-2

der(15)t(13;15)(q1?1;q11.2)
none, infertile
{1; 8}
15-
EHM-dup
pterq11.2/
1-3 to many

sSMC(15)
none
{sSMC
page}

15-
EHM-dup
q11.2q11.2/
1-1 to several

dup(15)(q11.2q11.2)
RP11-307C10

none
{0, 113}
15-
EHM-dup
q11.2q11.2/
2-1

dup(15)(q11.2q11.2)
RP11-138C5,
RP11-307C10
none
{0} 65424
15-
EHM-dup
q11.2q11.2/
3-1

dup(15)(q11.2q11.2)
RP11-2F9, RP11-138C5
none, infertile
{0} 60378
15-
EHM-dup
q11.2q13/
1-1

dup(15)(q11.2q13)
RP11-138C5

none
{1}
15-
EHM-dup
q11.2q13/
2-1

der(15)(D15Z1+),(RP11-2F9)amp,(RP11-138C5)amp,(RP11-307C10+),RP11-1109N12(amp),(RP11-380D11+)
none
{0-61015}